[Effect of 1,2,3,4-tetrahydroimidazo[4,5-c]pyridine and 1,2,3,4-tetrahydroisoquinoline derivatives on the behavior and the brain receptor system in rats].

Adducts obtained via the interaction of formaldehyde with histidine (1,2,3,4-tetrahydroimidazo[4, 5-c]pyridine-3-carboxylic acid (I)), tyrosine (7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (II)), and dopamine (6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (III)) influence the behavior and the state of the brain receptor system of rats upon chronic administration (10-day treatment at a daily dose of 50 mg/kg, i.p.). All the compounds studied decrease the horizontal and (to a lower extent) vertical motor activity and increase the quiescence period duration. On the other hand, the effects of compounds tested on the vegetative reactions were different: compounds I and III increased, whereas compound II decreased these reactions. Using the radioligand binding method, it was established that the treatment with compound I led to a decrease in the density of benzodiazepine receptors (B max of [3H]-flunitrazepam was 78% of the control level) and to a significant (148%) increase in the density of specific binding sites for [3H]-spiperone (reflecting the total density of dopamine (D2) and serotonin (5-HT2) receptors. The chronic administration of compound III produced a reliable decrease (76% of the control level) only in the density of benzodiazepine receptors. None of the tested compounds influenced the affinity of receptors with respect to the radioactive ligands used.

[Disorders of membrane mechanisms in stressor damage to the heart in rats of various strains]. / Narusheniia membrannykh mekhanizmov pri stressornykh povrezhdeniiakh serdtsa u krys razlichnykh linii.

The resistance of the rat's organism to emotional stress is determined by alterations of the heart's electric stability. The condition of lipid oxidation is accompanied by alterations of cholesterol and ionised calcium concentrations. Such alterations were expressed in Fisher rats to a greater extent. It conformed to the morphophysiological peculiarities of this group of animals and confirmed its considerable species sensibility.

[The effect of stimulation and blockade of the dopaminergic system on the choice of behavioral strategy by rats in the shuttle box]. / Vliianie stimuliatsii i blokady dofaminergicheskoi sistemy na vybor strategii povedeniia krys v chelnochnoi kamere.

Upon stimulation and blockade of dopaminergic system of rats in the shuttle box the correlation between the strategy of escape behavior and functional state of dopaminergic system has been found. The modulatory effect of these systems on the mechanism of the adequate choice is suggested.

[The action of korazol on the defensive behavior of rats]. / Vliianie korazola na oboronitel'noe povedenie krys.

The paper shows the dependence of behavioral changes provoked by corazol on individual characteristics of the animals. The rats with high activity in the ATS demonstrated the highest response to the drugs.

[The physiological reactions to stress in 3 strains of rats]. / Fiziologicheskie reaktsii na stress u krys trekh linii.

We have studied the resistance of Wistar, August, Fisher male rats to 2- and 24-hours immobilization by vegetative and behavioral reactions. The difference in the resistance has been observed both between the three lines of rats and within one particular line. The lowest resistance to stress has been demonstrated by Fisher rats, the highest by Wistar rats. The correlation between emotional reactivity of rats and their response to stress has been shown.

[The effect of malondialdehyde in the diet of pregnant and lactating female rats on the lipid peroxidation process and physical development of newborn rats]. / Vliianie malonovogo dial'degida v ratsione beremennykh i kormiashchikhkrys-samok na protsess perekisnogo okisleniia lipidov i fizicheskoe razvitie novorozhdennykh krysiat.

Intake of malonic dialdehyde (MDA) with drinking water by pregnant and lactating rats did not result in MDA accumulation in their body or in significant shifts in the system lipid peroxidation--antioxidant activity (LPO-AOA). However, two litters of progeny from rats, that ingested MDA, were found to be nonviable with drastically diminished mass of their brain and significant shifts in the system LPO-AOA. High content of MDA, sharply reduced concentration of lipid hydroperoxides, and lowered AOA were detected in the brain tissue, red blood cells and blood plasma of 15-day rats whose mothers ingested MDA during pregnancy and lactation. The lowered activity of the system LPO-AOA in the test young rats was attended by retardation of their physical development.

[Effect of amino acid derivatives of beta-carboline-3-carboxylate on rat behavior]. / Vliianie aminokislotnykh proizvodnykh beta-karbolin-3-karboksilata na povedenie krys.

It was shown, that administration of methyl ether N-(beta-carboline-3-carbonyl)-glycine (GA) at dose level of 1-10 mg/kg markedly reduced exploratory behavior and motor activity in the open field test and facilitated manifestation of different rats defend reaction types. Methyl ether N-(beta-carboline-3-carbonyl)-leucine (LA) at the same doses was less effective. Besides GA (10 mg/kg) like earlier described anxiogenic compound FG 7142 suppressed isolation induced muricide behavior of rats. The results obtained combined with literary data allow us to conclude, that GA possesses expressed anxiogenic activity.

[Health status and the characteristics of autonomic reactions in infants engaged in swimming]. / Sostoianie zdorov'ia i osobennosti vegetativnykh reaktsii detei rannego vozrasta, zanimaiushchikhsia plavaniem.

The health status of young children systematically engaged in swimming was evaluated with account of the physiological characteristics and results of an analysis of the anamnestic and catamnestic data. The health-improving effect of the swimming was noted, being more pronounced in children with risk factors. It was established that swimming did not produce any undesirable vegetative alterations. The possibility of its use as a means of the improvement and correction of children's development based on their individual characteristics is discussed.

[Comparative study of the effect of 3-carboxy-beta-carboline methylamide and diazepam on rat behavior]. / Sravnitel'noe izuchenie vliianiia metilamida 3-karboksi-beta-karbolina i diazepama na povedenie krys.

The effects of benzodiazepine receptor agonist, diazepam, and inverse agonist, FG 7142, were examined. Strong antagonism between FG 7142 (10 mg/kg) and diazepam (1 mg/kg) activity was revealed in the open field test. On the other hand, both FG 7142 and diazepam inhibited isolation-induced intraspecies aggressive behaviour of rats. FG 7142 also reduced interspecies aggression of mouse-killing rats. The findings suggest that both diazepam and FG 7142 have antiaggressive properties in the isolation-induced aggression model, which are mediated by benzodiazepine receptors of the central nervous system.

[Effect of stress experienced during pregnancy on the rate of lipid peroxidation in erythrocytes and brain tissue of newborn rat pups]. / Vliianie stressa, perenesennogo vo vremia beremennosti, na skorost' perekisnogo okisleniia lipidov v éritrotsitakh i tkani mozga u novorozhdennykh krysiat.

The rate of lipid peroxidation (LPO) in erythrocytes and brain homogenate has been assessed by the accumulation of malondialdehyde, the degree of erythrocyte autohemolysis, the content of hydrogen peroxide and catalase activity observed in newborn rats aged 1 hour, 1, 15, 20 and 30 days. Pregnant rats were exposed to emotional stress (aggressive interaction of two pregnant rats in an unavoidable conflict situation provoked by nociceptive irritation. Significant age-dependent differences in the rate of LPO (both in erythrocytes and cerebral tissue) have been found. The highest rate was noted in rats 15 days of age. The emotional stress of pregnant females resulted in the changes of behavioural reactions of newborn rats and LPO activity that was characterized by the increase in LPO rate in 1-hour- and 1-day-old rats and by slowing of LPO rate in 15-day-old rats. These phenomena were observed in erythrocytes and brain tissues of test animals.