RESUMEN
This is the second article in a two-part series published in this journal, in which we examine the histopathological characteristics, as well as the differential diagnosis, of the main entities that present as cystic and pseudocystic structures in cutaneous biopsy. In this second article, we address ciliated cutaneous cysts, branchial cysts, Bartholin's cysts, omphalomesenteric cysts, thymic cysts, thyroglossal duct cysts, synovial cysts, and median raphe cysts, as well as mucocele, ganglion, and auricular and digital myxoid pseudocysts.
Asunto(s)
Glándulas Vestibulares Mayores , Quistes , Femenino , Humanos , Quistes/patología , Diagnóstico Diferencial , Glándulas Vestibulares Mayores/patologíaRESUMEN
Cystic structures represent one of the most common findings in dermatopathology. These encompass both cystic tumors and pseudocysts resulting from the accumulation of certain substances, such as mucin. In a two-part series (of which this is the first part), we have reviewed the principal types of cysts and pseudocysts that may be observed in cutaneous biopsies, examining their histopathological features and primary differential diagnoses. This first part encompasses infundibular cysts, eruptive dermoid cysts, pigmented follicular cysts, pilonidal cysts, tricholemmal cysts, milium cysts, hybrid cysts, bronchogenic cysts, as well as steatocystoma, hydrocystoma, and comedones.
Asunto(s)
Quiste Broncogénico , Quiste Epidérmico , Humanos , Biopsia , Diagnóstico DiferencialRESUMEN
Nilotinib is a new multitargeted tyrosine kinase inhibitor, which is used to treat chronic myelogenous leukemia when intolerance or recurrence to imatinib occurs. We report the case of a 14-year-old patient being treated with nilotinib who developed a keratosis pilaris-like eruption. This cutaneous adverse effect is a rare but increasingly reported side effect of this therapy.
Asunto(s)
Anomalías Múltiples , Enfermedad de Darier , Cejas/anomalías , Adolescente , Antineoplásicos , Proteínas de Fusión bcr-abl , Humanos , Inhibidores de Proteínas Quinasas/efectos adversos , Pirimidinas/efectos adversosRESUMEN
High-frequency ultrasonography (HFUS) can help improve dermatofibrosarcoma protuberans (DFSP) recognition. We present three cases of DFSP in which a "jellyfish-like" sonographic pattern was a useful adjunct in formulating the diagnosis. In addition, we review all DFSP ultrasound images available in the literature.
Asunto(s)
Dermatofibrosarcoma/diagnóstico por imagen , Neoplasias Cutáneas/diagnóstico por imagen , Niño , Dermatofibrosarcoma/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Cutáneas/patología , UltrasonografíaAsunto(s)
Terapia por Láser/métodos , Enfermedades Cutáneas Genéticas/patología , Enfermedades Cutáneas Genéticas/terapia , Adulto , Biopsia con Aguja , Cicatriz/diagnóstico , Cicatriz/terapia , Diagnóstico Diferencial , Dermatosis Facial/diagnóstico , Dermatosis Facial/terapia , Humanos , Inmunohistoquímica , Masculino , Enfermedades Raras , Enfermedades Cutáneas Genéticas/diagnóstico , Resultado del TratamientoRESUMEN
High-frequency ultrasonography is a bedside tool increasingly used for the assessment of skin lesions, but there have been few reports about its importance in children with skin signs of hematologic disease. We present three cases to highlight the usefulness of high-frequency ultrasonography in assisting with the diagnosis of these skin lesions.
Asunto(s)
Neoplasias Hematológicas/patología , Neoplasias Cutáneas/diagnóstico por imagen , Ultrasonografía/métodos , Niño , Femenino , Humanos , Lactante , Masculino , Piel/diagnóstico por imagen , Piel/patología , Neoplasias Cutáneas/patologíaRESUMEN
Follicular mucinosis can develop as a primary form or associated with other benign or malignant skin conditions. We present a case of primary follicular mucinosis in which complete clinical remission was achieved after treatment with topical imiquimod 5%. Primary follicular mucinosis (PFM), also called idiopathic alopecia mucinosa, is considered a distinct entity, the clinical course of which is usually benign, but its pathogenesis remains unclear. There is no standard treatment for PFM, and a wide variety of therapies have been described. There are no previous reports of treatment of PFM with imiquimod.
Asunto(s)
Adyuvantes Inmunológicos/administración & dosificación , Aminoquinolinas/administración & dosificación , Mucinosis Folicular/tratamiento farmacológico , Mucinosis Folicular/patología , Administración Tópica , Biopsia , Niño , Humanos , Imiquimod , Masculino , Resultado del TratamientoRESUMEN
Acral erythema is a frequent cutaneous reaction related to chemotherapy. A patient presented herein developed acral erythema related to cytosine arabinoside treatment and then graft versus host disease (GVHD). Subsequently, worsening of palmar erythema and pain occurred with intravenous cyclosporin infusions.
Asunto(s)
Ciclosporina/efectos adversos , Citarabina/uso terapéutico , Eritema/inducido químicamente , Enfermedad Injerto contra Huésped/tratamiento farmacológico , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Adulto , Antineoplásicos/uso terapéutico , Erupciones por Medicamentos/etiología , Eritema/terapia , Humanos , Infusiones Intravenosas , Masculino , Metotrexato/uso terapéuticoRESUMEN
Circumscribed acral hypokeratosis (CAH) is a rare dermatosis that typically appears as well-dermarcated erythema with a scaly border on the palms or soles of middle-age patients. A pediatric case of CAH has been recently reported in a 10-year-old boy affecting the medial foot since birth. In this report we describe the second congenital case of CAH on the sole.
Asunto(s)
Epidermis/patología , Dermatosis del Pie , Queratosis/diagnóstico , Queratosis/patología , Biopsia , Preescolar , Diagnóstico Diferencial , Dermatosis del Pie/congénito , Dermatosis del Pie/diagnóstico , Dermatosis del Pie/patología , Humanos , MasculinoRESUMEN
Severe combined immunodeficiency includes a group of diseases characterized by different inherited immunological defects. A 4-month-old girl diagnosed with Omenn syndrome, a subtype of severe combined immunodeficiency presenting with generalized erythroderma, was referred to our hospital for an allogeneic stem cell transplantation. Days before transplantation, she developed hyperpigmented macules that increased in number in the following months. As the erythroderma resolved after transplantation, diffuse hypopigmentation was simultaneously noted together with the expansion of hyperpigmented lesions. Cutaneous biopsy samples were taken at different moments, showing features of Omenn syndrome at first, and 2 months later changes consistent with hypopigmentation and repigmentation were observed. Although pigmentary disorders are rarely described in this context, these must be taken into account as a possible alternative diagnosis to graft-versus-host disease and toxicoderma in immunosuppressed patients.