Cross-cultural validation and Spanish translation of the Boston Interview to evaluate severely obese patients seeking metabolic/bariatric surgery.

INTRODUCTION: obesity is a global health problem. Metabolic/Bariatric surgery (MBS) has proven to be one of the most effective methods for treating the most severe forms. However, a thorough evaluation and preparation of people seeking MBS is necessary. In Spain, there are no standardized interviews to carry out the psychosocial assessment of people seeking MBS. The Boston Interview for MBS (BIBS) is a recognized and flexible tool to evaluate the psychosocial factors. OBJECTIVE: to present the process of translation into Spanish and cross-cultural adaptation of the BIBS. MATERIALS AND METHODS: the reverse translation procedure was followed. To validate the translation, a multidisciplinary group of experts was formed. They were asked to rate the clarity of wording and cultural adaptation of the translation items. In addition, the translated interview was used to evaluate 173 patients seeking MBS who rated their satisfaction with the interview experience. RESULTS: the evaluation of the translation by a group of experts was favorable (global mode and median were 3-excellent, IQR of 1). The overall percentage agreement of the adequacy of "cultural adaptation" of the text was 85.8 % (95 % CI, 0.784, 0.932) and of the "clarity of wording" was 84.7 % (95 % CI, 0.7644; 0.9286). Furthermore, it was well accepted by the majority of the patients interviewed (p(50) 10 out of 10). CONCLUSIONS: the Spanish translation of the BIBS is available for the assessment of Spanish-speaking people seeking MBS. It was rated as having good fidelity to the original English version, and was deemed highly satisfactory by patients.

The association of the persecutory ideation questionnaire with clinically-relevant and other outcomes: the moderating role of confidence.

One of the most used self-administered instruments to assess persecutory delusions is the Persecutory Ideation Questionnaire (PIQ). Individual differences in PIQ scores are important because they predict the severity of symptoms associated with psychosis-related disorders. The current research demonstrates that PIQ is associated with two new outcomes: Satisfaction with life (Studies 1 and 2) and therapy length needed for hospital discharge (Study 2). Most relevant, we introduce meta-cognitive confidence in one's scale responses as a construct capable of improving the predictive validity of the PIQ. Across two studies, participants from the general population (Study 1) and from a clinical sample (Study 2) completed the PIQ and then reported the confidence in their responses. As expected, the PIQ was associated with satisfaction with life in both cases and duration of therapy required to receive hospital discharge for the clinical sample. Most importantly, confidence further moderated the extent to which the PIQ scores were linked with both outcomes, with greater consistency between the PIQ and the dependent measures obtained for those with higher confidence. Therefore, asking a single item about the confidence associated with responses to the PIQ enhances the association of PIQ scores and relevant consequences across domains.

Inflammatory profiles in women with eating disorder: Linking inflammatory biomarkers to clinical phenotypes.

INTRODUCTION: Eating disorders (ED) represent a group of very complex and serious diagnoses characterized by emotional dysregulation and impulsivity. New approaches are necessary to achieve effective diagnosis and treatments. Shifting biomarker research away from the constraints of diagnostic categories may effectively contribute to a dimensional differentiation across disorders according to neurobiology (e.g., inflammatory biomarkers). Thus, the aim of our study was to identify inflammatory profiles in patients with ED. METHODS: A sample of 100 women with an ED (23.4 ± 8.55 years) and 59 healthy controls (HC) (20.22 ± 4.18 years) was used. K-means cluster analysis was followed to identify inflammatory clusters considering seven blood biomarkers (iNOS, TNFα, COX2, p38, ERK, TBARS and PPARγ). Moreover, a wide assessment of clinical features was conducted. RESULTS: Two distinct clusters were identified. Cluster 1 patients were characterized by higher inflammatory levels of TNF-α, COX2, p38, and ERK, and had more restrictive anorexia diagnosis than cluster 2. Cluster 2 participants showed higher inflammatory levels of iNOS and were older than cluster 1 and controls and had lower BMI than HC. In addition, they had higher levels of bulimic symptoms than those from the cluster 1 and HC, and higher impulsivity than HC. All ED patients (regardless of cluster) showed higher ED symptoms and more trauma than HC. CONCLUSIONS: Our study revealed that inflammatory dysfunction may be linked with clinical endophenotypes in ED, one more restrictive (cluster 1) with an inflammation/oxidative endophenotype more cytokine and MAPK/ERK mediated, and the other more impulsive, with more bulimic symptoms (cluster 2) with NO free radical high output source iNOS. Trauma seems to be a vulnerability factor for both endophenotypes.

Influencia de la percepción de la crianza sobre la actitud hacia el cambio en los trastornos de la conducta alimentaria / Influence of parental rearing styles on attitude towards change in eating disorders

Resumen: Objetivo: Identificar la posible influencia de los «estilos de la crianza¼ con la «actitud hacia el cambio¼ en pacientes diagnosticadas de trastorno de la conducta alimentaria según criterios DSM-IV-TR (American Psychiatric Association -APA-, 1994). Método: Fueron incluidas 166 pacientes de las cuales 66 (39.8%) recibieron el diagnóstico de bulimia nerviosa, 49 (29.5%) de anorexia nerviosa y 51 (30.7%) de trastorno de la conducta alimentaria no especificado. Todas las pacientes completaron una batería de cuestionarios para evaluar las relaciones familiares (APGAR familiar), los recuerdos de su crianza y su actitud hacia el cambio (ACTA) al año de seguimiento. Resultados: En el análisis de regresión múltiple realizado, se observó que la «sobreprotección¼ percibida en la infancia se relacionaba con mayores puntuaciones en «precontemplación¼ y menores puntuaciones en «acción¼ y «mantenimiento¼ . Por otra parte, el «rechazo¼ percibido en la crianza se relacionaba con puntuaciones más elevadas en «precontemplación ¼, independientemente del grado de disfunción familiar existente. Por último, el «afecto¼ percibido se relacionaba directamente con puntuaciones superiores en la fase de «acción¼ . Conclusiones: Estos resultados nos muestran la importancia de la crianza en aspectos tan relevantes del tratamiento como la motivación ante el cambio.

Abstract: Objective: To evaluate the relationships between "parental rearing styles" and "attitude towards change" in eating disorders patients according to DSM-IV-TR (American Psychiatric Association -APA-, 1994). Methods: A total of 166 patients was evaluated: 66 (39.8%) patients met criteria for bulimia nervosa, 49 (29.5%) patients met criteria for anorexia nervosa and 51 (30.7%) patients met criteria for an eating disorder not otherwise specified. All the patients completed a set of self-administered questionnaires to evaluate their family relationships (APGAR familiar), their memories of parental upbringing and their attitudes towards change (ACTA) after one year treatment. Results: A multiple regression analysis was performed. "overprotection " perceived during childhood was related to higher scores in "pre-contemplation " and lower scores in "action " and "maintenance ". On the other hand, "rejection " during upbringing was related to higher scores in "pre-contemplation " at one year follow-up regardless of family dysfunction. Finally, "warm " perceived was related to higher scores in "action" . Conclusions: These results show the relevance of breeding in treatment important aspects in eating disorders patients.