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Bioorg Med Chem Lett
; 19(3): 701-5, 2009 Feb 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19114305
RESUMEN
The optimization of compounds from the 3-amido-4-anilinoquinolines series of CSF-1R kinase inhibitors is described. The series has excellent activity and kinase selectivity. Excellent physical properties and rodent PK profiles were achieved through the introduction of cyclic amines at the quinoline 6-position. Compounds with good activity in a mouse PD model measuring inhibition of pCSF-1R were identified.