Medical anticancer treatment of lung cancer associated with comorbidities: a review.

Comorbidities are frequent in patients with lung cancer, who are often treated with systemic anticancer therapy. The purpose of the present review is to report the adaptations recommended for the various drugs used in lung cancer treatment, in the context of a specific comorbidity. The literature was reviewed for neurologic, endocrine, hepatic, renal, digestive, cardiovascular, pulmonary, blood and systemic diseases. The comorbidities impact on the systemic anticancer treatment is poorly assessed. There are no good data with a high level of evidence and literature is often limited to experts' opinion and to case reports. We need to improve our knowledge about those patients by adequate multicentric and prospective studies and registries in order to offer them better care in term of evidence-based medicine.

[Acute interstitial pneumonia and bronchial cancer]. / Pneumopathie interstitielle aiguë et cancer bronchique.

A 64 year-old woman with a lung cancer metastatic to the bone was admitted to the Intensive Care Unit for a hypoxemic interstitial diffuse pneumonia. The diagnosis was obtained with a further complementary investigation. The differential diagnosis of intestitial pneumonia is discussed.

[Mediastinal mass, pulmonary infiltration, and meningitis]. / Masse médiastinale, infiltrat pulmonaire et méningite.

A 42 year-woman suffering from a non-small cell lung cancer, presenting initially as a mediastinal tumor, is hospitalized for fever, headaches and nausea. An aseptic meningitis is diagnosed. The patient died despite the administration of broad spectrum antibiotics and antituberculous agents. The differential diagnoses are presented.