1.
Bioorg Med Chem Lett
; 21(21): 6336-40, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21930381
RESUMEN
The construction of a EP(4) antagonists pharmacophore model and the discovery of a highly potent oxepinic series of EP(4) antagonists is discussed. Compound 1a exhibits an excellent selectivity profile toward EP(2) receptor subtype and low cytochrome P450 inhibition potential.