CHARACTERISTICS OF THE AUTONOMIC NERVOUS SYSTEM STATE, ASSESSED BY THE HEART RATE VARIABILITY STUDY IN CIRRHOTIC PATIENTS WITH SYNTROPIC CARDIOMYOPATHY AND ITS FEATURES DEPENDING ON THE QT INTERVAL DURATION.

The patients with liver cirrhosis (LC) have autonomic nervous system (ANS) imbalance that can be evaluated by the heart rate variability (HRV) study. ANS imbalance results into cirrhotic cardiomyopathy (CCMP) and the most easily diagnosed feature of CCMP is the prolonged QT interval. Usually, in the literature not all HRV parameters are characterized, or their assessment period is short, not allowing covering all the important moments and therefore needing further study. In a randomized way with the preliminary stratification by the presence of LC 33 patients after signing the informed consent were examined. In addition to routine screening methods, all patients underwent 24-hour ECG monitoring. Patients with LC and syntropic CCMP have the ANS disorders with a HRV decrease, predominance of the sympathetic over the parasympathetic system, heart rate regulation at the humoral-metabolic level. The ANS disorders severity depend on the LC severity according to C. G. Child-R. N. Pugh criteria. During the analysis of the received results the significant positive correlation between the SDNN index and maxQT, avg QT, positive correlation between HF and max QTc, avg QTc were found. The diagnostic sensitivity of SDNN index and HF was high in the patients with LC and CCMP. The ANS imbalance can be regarded as syntropic comorbid disorder in the cirrhotic patients. The diagnostic sensitivity of SDNN index and HF was found to be high in the patients with LC and CCMP, serving as diagnostic markers of CCMP.

CRITERIA FOR DIAGNOSIS OF CARDIOMYOPATHY IN PATIENTS WITH ALCOHOLIC LIVER CIRRHOSIS BEFORE THE ONSET OF HEART DAMAGE CLINICAL SIGNS.

The article clarifies the diagnostic criteria for syntropic heart damage - cardiomyopathy in patients with Alcoholic Liver Cirrhosis before the clinical signs of heart damage appear. As a result of the examination of 64 patients with Cirrhotic Cardiomyopathy, of which 51 patients were identified without clinical signs of heart damage (study group 1), 13 patients with clinical signsof heart damage (study group 2), and 23 patients without cardiomyopathy (comparison group), it was found that: 1) in patients with Cirrhotic Cardiomyopathy (both with and without manifestation of clinical signs of heart damage), there is a violation of its diastolic and systolic functions, which can be diagnosed by change of parameters of the natriuretic peptide in the blood plasma, the frequency of supraventricular premature beats and premature ventricular contractions, the duration of the QT interval, the maximum blood flow velocity in the phase of early filling of the left ventricle and the left atrium systole, their ratio, the myocardial functional capacity index, end-diastolic and end-systolic volumes of the left ventricle and left atrium; 2) in patients with Cirrhotic Cardiomyopathy without clinical manifestations, significantly lower (p<0.05) indicators of the natriuretic peptide, the frequency ofextrasystoles, the end-diastolic and end-systolic volumes of the left ventricle and left atrium, and a higher rate of ejection fraction of the left ventricle were revealed than in patients with the clinical manifestation of this disease; 3) we found high accuracy, specificity and sensitivity of the indicators of the natriuretic peptide, the QT interval (maximum, maximum corrected, average, mid-corrected), maximum blood flow velocity in the phase of early filling of the left ventricle and of the systole of the left atrium, their ratio, as well as the myocardial functional capacity index in patients with alcoholic liver cirrhosis with an asymptomatic course of cardiomyopathy that allows to use them to verify the diagnosis of Cirrhotic Cardiomyopathy until the first clinical signs of myocardial damage appear.