1.
Bioorg Med Chem Lett
; 27(20): 4622-4625, 2017 10 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28927786
RESUMEN
A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue. The design was based on crystal structure information and a comparative study of several electrophilic warheads.