RESUMEN
Pharmacokinetics and relative bioavailability of antidepressant GSB-106 (hexamethylendiamide bis-(N-monosuccinyl-L-seryl-L-lysine) were determined in rabbits after single oral administration of the pharmaceutical substance and tablet mass. GSB-106 concentrations in the blood plasma were determined by HPLC-mass spectrometry. Relative bioavailability of GSB-106 tablet form was 160.79±24.33%.
Asunto(s)
Antidepresivos/farmacocinética , Dipéptidos/farmacocinética , Administración Oral , Animales , Antidepresivos/sangre , Área Bajo la Curva , Disponibilidad Biológica , Dipéptidos/sangre , Evaluación Preclínica de Medicamentos , Masculino , Conejos , ComprimidosRESUMEN
The main pharmacokinetic parameters (AUC0-∞, Tmax, Cmax, Cl/F, t1/2 el, MRT, Cmax/AUC0-I, Vd/F) of afobazole base in a new pharmaceutical composition and afobazole dihydrochloride substance after single peroral administration have been determined in rats. The availability of afobazole base pharmaceutical composition relative to that of the substance amounted to 153.2%.
