[The effect of cerebrolysin on the regeneration of the peripheral nerve depending on the scheme of paraneural administration].

An experimental morphological study in 56 animals has been performed in order to analyze the effect of cerebrolysin on the dynamics and long-term results of peripheral nerve regeneration after the transection and microsurgical suturing depending on the scheme of the preparation of paraneural infusion. The regeneration process was evaluated after 2.5; 4; 6 and 12 months. There was a stimulating effect of the preparation on the regenerative growth and differentiation of nerve fiber axial cylinders, vascularization of the distal segment of regenerating nerve and the trophic condition of myelin-forming Schwann cells. When the preparation is used according to the prolonged scheme, the effect persists for up to 10.5 months after the end of paraneural injection course.

[State of lower alveolar and mental nerves by mandible fractures healing under transbone osteosynthesis].

Fracture of mandibular body at the level of P3-P4 with symphysis rupture was modeled, reposition and transosseous osteosynthesis with a specially developed device were performed under anesthesia in the operating room in 17 adult mongrel dogs in order to specify the pathogenesis and the dynamics of injury and jaw nerve regeneration. It has been established, that the arrangement of the neurovascular bundle in medullary canal predetermines the development of acute and chronic compression-and-ischemic neuropathy even if accurate reposition of bone fragments takes place. The histological signs of nerve fiber regeneration, the loss of the quantity of myelin-free nerve conductors and the retrograde spreading of degenerative changes in myelinized nerve conductors, including regenerating ones, have been found beginning from 4 weeks after injury. It has been concluded, that spontaneous nerve regeneration in case of mandibular fractures should be actively supported by neuroprotective, anti-edematous and anti-inflammatory therapy.

[Morphometric evaluation of the effectiveness of post-traumatic peripheral nerve regeneration after a single and repeated courses of electrostimulation].

Sciatic nerve (SN) transection and microsurgical suture were performed in 41 dogs to assess the effect of electrostimulation (ES) on peripheral nerve regeneration. 23 dogs served as a control group, ES of the spinal cord and SN was made with alternating current of 50-Hz frequency in 18 dogs: in 13 dogs one course of 18 sessions was performed within the period of 1-2.5 months after surgery (ESL1), in 5 dogs two courses were performed: the first one--in a similar time interval, the second one--within 6-7.5 months after surgery (ES2). The mean diameter of myelinated fibers (MF) after 2.5, 4, 6, and 12 postoperational months for ES1 was significantly greater than the control values, mainly due to the increase of axonal diameter. After 12 months, the tendency towards the restoration of MF diameter bimodal distribution was marked in ES2, and, to a lesser degree, in ES1. Thus, it was found that ES effectively activates the regeneration and differentiation of MF, but leads to their relative hypomyelination.

[Intranasal administration of immunoglobulins--perspectives for use in medical practice].

Effectiveness of topical use of immunoglobulines in respiratory infections along with preparations for parenteral use is discussed. Immunoglobuline preparations for intranasal use (drops, spays, aerosols) should take place among preparations intended for prevention and treatment of influenza, parainfluenza, respiratory syncitial virus infection and others. Potential to intranasal use of complex immunoglobulin preparation containing polymeric and monomeric antibodies of different isotypes is also discussed.

[Peculiarities of sciatic nerve endoneurium cellular composition in hip distraction osteosynthesis in dogs].

Using light and electron microscopy, sciatic nerve endoneurium cellular content was studied in 14 adult mongrel dogs subjected to hip elongation for 28-35 days after osteotomy. For light microscopy, semithin sections were prepared. The application of an automated image analysis has demonstrated a moderate increase in macrophage, fibroblast and mast cell content, which remained undetected during visual examination. The morphofunctional state and the distribution of these cells is suggestive of their participation in the extracellular matrix synthesis and remodeling, angiogenesis control, blood flow and endoneurial fluid content regulation in the process of peripheral nerve structural adaptation to extremity elongation.

[Clinical manifestations of cross-allergic reactions to food among children].

Scientists have recently studied the frequency and possible forms of clinical manifestations of cross-reactivity to food among 239 of Abakan at the age from 6 month to 15 years with skin, respiratory and combined manifestation of atopy It was proved that risk factors of development of cross-reactivity to food occur among 80% of children who have various forms of allergic diseases moreover the cross allergic reactions between the foodstuffs most frequently occur with the gastrointestinal and with skin forms of food allergy and the cross allergic reactions between the pollen and food allergens more frequently occut with the respiratory forms of atopy and dermorespiratory syndrome. Considerably more rarely this type of reactions is discovered between the epidermal and food allergens, which most frequently were revealed with the dermatorespiratory syndrome.

[Risk factors and etiological structure of children's cross-allergic reactions to food products]. / Faktory riska i étiologicheskaia struktura perekrestnykh allergicheskikh reaktsii na pishchevye produkty u detei.

Authors of article have recently analyzed the frequency of prevalence and risk factors of cross-reactivity to foodstuffs among 239 children of Abakan in the age of from 6 months till 15 years with skin, respiratory and combined manifestation of atopy. It was proved that risk factors of development of cross-reactivity to food among children of the first years of life are hereditary predisposition to allergic diseases (77.8%) and early introductions of supplemental feeding (44%). Among children older then 7 years pollen sensitization (62%) which preceded the development of cross allergic reactions between separate foodstuffs reaches up to 73.7%, between pollen and foodstuff up to 79% and between epidermal and food up to 10.1%.

[Types of coaptation of nerve fiber bundles and effectiveness of the nerve suture]. / Tipy koaptatsii puchkov nervnykh volokon i rezul'tativnost' shva nerva.

Experiments in 26 dogs were carried out in order to analyze the quality of comparing the nerve fiber bundles, morphometrical and functional parameters of regeneration after the restoration of the nerve with a standard epineural microsurgical suture and by an original method including the coaptation of the freshened ends by a relaxation transneural suture followed by epiperineural microneurorrhaphy. Five variants of the comparison of the nerve fiber bundles in the suture zone are described. The results of expert assessments and computed morphometry allowed to register higher indices of regeneration and differentiation of nerve fibers.

[Evaluation on monkeys of reactogenicity and effectiveness of the complex immunoglobulin preparation formulation]. / Otsenka na obez'ianakh reaktogennocti i éffektivnosti lekarstvennykh form kompleksnogo immunoglobulinovogo preparata.

Experiments on 75 monkeys, 20--healthy and 75--with diarrhea, showed that ready medicinal forms of the complex immunoglobulin preparation in tablets, capsules or in a dried form (vials) were safe, well tolerated, clinically and bacteriologically effective. When used simultaneously with antiparasitic treatment, this preparation, irrespective of the kind of its ready medicinal form, showed high curative effect (80-90%). The diarrhea ceasing was accompanied by the gradual normalization of intestinal microbiocenosis (an increased concentrations of Escherichia coli and Bifidobacterium, a decreased amount of opportunistic bacteria). The complex method of the treatment of diarrhea in monkeys (antibiotics, trichopol, phage and probiotics) made it possible to achieve curative effect only in 60% of cases, which required the additional course of treatment, namely the use of rehydration therapy.

[Computer application in business games at the military department of medical school]. / O primenenii EVM v delovykh igrakh pri obuchenii studentov na voennoi kafedre medinstituta.

Computerized practical games are considered to be an effective method that could intensity and enhance the quality of training for medical service reserve officers. At the military chair of Kursk State Medical Institute a fund of practical games was created. It includes final themes on the courses of organization and tactics of medical service, military toxicology and NBC medical defense. Practical games develop students' ability to analyse combat, logistic and medical situation, help them make a correct assignment of medical forces and means, or take opportune steps in decision-making.

[The determination of pyrazidol in blood and urine]. / Opredelenie pirazidola v krovi i moche.

Methods of pyrazidole isolation from blood and urine as well as of its identification and quantification are developed. These methods allow one to isolate 53-55% of pyrazidole from blood and 90-95%, from urine.

[Clinical use of tramal in patients in the early postoperative period]. / Klinicheskoe primenenie tramala u bol'nykh v rannem posleoperatsionnom periode.

Tramal was given to 204 patients who were operated on the lung, heart, abdomen. During pain therapy, good and satisfactory results were on average obtained in 75% patients operated on the lung, in 77%, on the heart, in 89%, on the abdomen, in 70%, on the great vessels. The absence of the inhibitory effect of the drug on the respiratory center and its slightly marked sedative effect allow one to recommend the agent for application in the early period following the surgery when narcotic analgesics still retain their effect and a real risk of their overdosage exists. During prolonged artificial pulmonary ventilation in the early postoperative period and in impaired adaptation of the patients to a respirator, tramal aids normalization of lung mechanics and hemodynamic parameters without eliminating and suppressing the patients' consciousness and results in cessation of muscular shivering. Adverse effects of tramal are of no decisive clinical significance and occur mainly when the drug is rapidly injected into the vein.

[Current methods of assessing hemodynamics in the intensive care unit (comparative aspects)]. / Sovremennye metody otsenki gemodinamiki v usloviiakh otdeleniia intensivnoi terapii (sravnitel'nyi aspekt).

The paper deals with comparative characterization of validity shown by current techniques for assessing hemodynamic parameters such as radiocardiography, echocardiography, Doppler cardiography, electroimpedance indicator separation, alveolar gas carbon dioxide concentration change technique, tetrapolar chest rheography and their potential role in the practice of intensive care and resuscitation units.

[Neutralizing action of human blood preparations on Shigella enterotoxins and choleragen]. / Neitralizuiushchee deistvie preparatov krovi v cheloveka na énterotoksiny Shigella i kholerogen.

The possibility of neutralizing the enterotoxic activity of S. dysenteriae 1 neurotoxin, S. sonnei live virulent cultures and cholerigen with immune sera of different animals, normal human sera and commercial gamma-globulin preparations is shown.

[Use of anodization for the protective and surface finishing of dental instruments made of aluminum alloys]. / Primenenie ématalirovaniia dlia zashchitno-dekorativnoi otdelki zubovrachebnykh nakonechnikov iz aliuminievykh splavov.

Based on a study of thickness, quality and corrosion resistance of anodized films deposited on aluminium alloys D16T and B95 depending on electrolyte composition and oxidation parameters the optimum composition and operating process for the above alloys are established. The oxidation parameters affect in a much less degree the quality of films deposited on the alloy B95 thus permit recommending it for production of medical instruments.