Evolving strategies and application of proteins and peptide therapeutics in cancer treatment.

Several proteins and peptides have therapeutic potential and can be used for cancer therapy. By binding to cell surface receptors and other indicators uniquely linked with or overexpressed on tumors compared to healthy tissue, protein biologics enhance the active targeting of cancer cells, as opposed to the passive targeting of cells by conventional small-molecule chemotherapeutics. This study focuses on peptide medications that exist to slow or stop tumor growth and the spread of cancer, demonstrating the therapeutic potential of peptides in cancer treatment. As an alternative to standard chemotherapy, peptides that selectively kill cancer cells while sparing healthy tissue are developing. A mountain of clinical evidence supports the efficacy of peptide-based cancer vaccines. Since a single treatment technique may not be sufficient to produce favourable results in the fight against cancer, combination therapy is emerging as an effective option to generate synergistic benefits. One example of this new area is the use of anticancer peptides in combination with nonpeptidic cytotoxic drugs or the combination of immunotherapy with conventional therapies like radiation and chemotherapy. This review focuses on the different natural and synthetic peptides obtained and researched. Discoveries, manufacture, and modifications of peptide drugs, as well as their contemporary applications, are summarized in this review. We also discuss the benefits and difficulties of potential advances in therapeutic peptides.

Implications of cancer stem cells in diabetes and pancreatic cancer.

This review provides a detailed study of pancreatic cancer (PC) and the implication of different types of cancers concerning diabetes. The combination of anti-diabetic drugs with other anti-cancer drugs and phytochemicals can help prevent and treat this disease. PC cancer stem cells (CSCs) and how they migrate and develop into malignant tumors are discussed. A detailed explanation of the different mechanisms of diabetes development, which can enhance the pancreatic CSCs' proliferation by increasing the IGF factor levels, epigenetic modifications, DNA damage, and the influence of lifestyle factors like obesity, and inflammation, has been discussed. It also explains how cancer due to diabetes is associated with high mortality rates. One of the well-known diabetic drugs, metformin, can be combined with other anti-cancer drugs and prevent the development of PC and has been taken as one of the prime focus in this review. Overall, this paper provides insight into the relationship between diabetes and PC and the methods that can be employed to diagnose this disease at an earlier stage successfully.

The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis.

The human microbiome's role in colon and breast cancer is described in this review. Understanding how the human microbiome and metabolomics interact with breast and colon cancer is the chief area of this study. First, the role of the gut and distal microbiome in breast and colon cancer is investigated, and the direct relationship between microbial dysbiosis and breast and colon cancer is highlighted. This work also focuses on the many metabolomic techniques used to locate prospective biomarkers, make an accurate diagnosis, and research new therapeutic targets for cancer treatment. This review clarifies the influence of anti-tumor medications on the microbiota and the proactive measures that can be taken to treat cancer using a variety of therapies, including radiotherapy, chemotherapy, next-generation biotherapeutics, gene-based therapy, integrated omics technology, and machine learning.

Elimination of microplastics from the aquatic milieu: A dream to achieve.

Microplastics (MPs) have become a significant source of concern as they have emerged as a widespread pollutant that harms the aquatic environment. It has become an enormous challenge, having the capacity to biomagnify and eventually affect human health, biodiversity, aquatic animals, and the environment. This review provides in-depth knowledge of how MPs interact with different toxic organic chemicals, antibiotics, and heavy metals in the aquatic environment and its consequences. Membrane technologies like ultrafiltration (UF), nanofiltration (NF), microfiltration (MF), and dynamic membranes can be highly effective techniques for the removal of MPs. Also, hybrid membrane techniques like advanced oxidation processes (AOPs), membrane fouling, electrochemical processes, and adsorption processes can be incorporated for superior efficiency. The review also focuses on the reactor design and performance of several membrane-based filters and bioreactors to develop practical, feasible, and sustainable membrane technologies. The main aim of this work is to throw light on the alarming scenario of microplastic pollution in the aquatic milieu and strategies that can be adopted to tackle it.

Recent advances in green technology and Industrial Revolution 4.0 for a sustainable future.

This review gives concise information on green technology (GT) and Industrial Revolution 4.0 (IR 4.0). Climate change has begun showing its impacts on the environment, and the change is real. The devastating COVID-19 pandemic has negatively affected lives and the world from the deadly consequences at a social, economic, and environmental level. In order to balance this crisis, there is a need to transition toward green, sustainable forms of living and practices. We need green innovative technologies (GTI) and Internet of Things (IoT) technologies to develop green, durable, biodegradable, and eco-friendly products for a sustainable future. GTI encompasses all innovations that contribute to developing significant products, services, or processes that lower environmental harm, impact, and worsening while augmenting natural resource utilization. Sensors are typically used in IoT environmental monitoring applications to aid ecological safety by nursing air or water quality, atmospheric or soil conditions, and even monitoring species' movements and habitats. The industries and the governments are working together, have come up with solutions-the Green New Deal, carbon pricing, use of bio-based products as biopesticides, in biopharmaceuticals, green building materials, bio-based membrane filters for removing pollutants, bioenergy, biofuels and are essential for the green recovery of world economies. Environmental biotechnology, Green Chemical Engineering, more bio-based materials to separate pollutants, and product engineering of advanced materials and environmental economies are discussed here to pave the way toward the Sustainable Development Goals (SDGs) set by the UN and achieve the much-needed IR 4.0 for a greener-balanced environment and a sustainable future.