RESUMEN
OBJECTIVE: To evaluate the relationship between brain damage biomarkers and mortality in the intensive care unit (ICU). METHODS: The sample comprised 70 patients admitted to an ICU. Blood samples were collected from all patients on ICU admission, and levels of S100ß and neuron-specific enolase (NSE) were determined by ELISA. RESULTS: Acute Physiologic and Chronic Health Evaluation (APACHE II) score was associated with mortality, but NSE and S100ß were not associated with this outcome. In contrast, S100ß levels were significantly higher in delirious and non-delirious patients who required mechanical ventilation during ICU stay. CONCLUSION: Levels of brain biomarkers at the time of ICU admission did not predict mortality in critically ill patients.
Asunto(s)
Lesiones Encefálicas/mortalidad , Enfermedad Crítica/mortalidad , Delirio/sangre , Fosfopiruvato Hidratasa/sangre , Subunidad beta de la Proteína de Unión al Calcio S100/sangre , APACHE , Biomarcadores/sangre , Lesiones Encefálicas/sangre , Estudios de Casos y Controles , Ensayo de Immunospot Ligado a Enzimas , Femenino , Humanos , Unidades de Cuidados Intensivos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios ProspectivosRESUMEN
Objective: To evaluate the relationship between brain damage biomarkers and mortality in the intensive care unit (ICU). Methods: The sample comprised 70 patients admitted to an ICU. Blood samples were collected from all patients on ICU admission, and levels of S100β and neuron-specific enolase (NSE) were determined by ELISA. Results: Acute Physiologic and Chronic Health Evaluation (APACHE II) score was associated with mortality, but NSE and S100β were not associated with this outcome. In contrast, S100β levels were significantly higher in delirious and non-delirious patients who required mechanical ventilation during ICU stay. Conclusion: Levels of brain biomarkers at the time of ICU admission did not predict mortality in critically ill patients. .
