RESUMEN
BACKGROUND: Fasting is known to influence the immune functions of leukocytes primarily by regulating their mobilization and redistribution between the bone marrow and the peripheral tissues or circulation, in particular via relocalization of leukocytes back in the bone marrow. However, how the immune system responds to the increased risk of invasion by infectious pathogens with fewer leukocytes in the peripheral blood during fasting intervention remains an open question. RESULTS: We used proteomic, biochemical and flow cytometric tools to evaluate the impact of short-term intensive fasting (STIF), known as beego, on red blood cells by profiling the cells from the STIF subjects before and after 6 days of fasting and 6 days of gradual refeeding. We found that STIF, by triggering the activation of the complement system via the complement receptor on the membrane of red blood cells, boosts fairly sustainable function of red blood cells in immune responses in close relation to various pathogens, including viruses, bacteria and parasites, particularly with the pronounced capacity to defend against SARS-CoV-2, without compromising their oxygen delivery capacity and viability. CONCLUSION: STIF fosters the immune function of red blood cells and therefore, it may be considered as a nonmedical intervention option for the stronger capacity of red blood cells to combat infectious diseases.
RESUMEN
Polyoxometalate nanoparticles were synthesized via a concise solid-state reaction method by directly grinding silver nitrate and the polyoxometalate (NH4)5H6PMo4V8O40 at room temperature without the assistance of a surfactant. The as-prepared Ag6(NH4)5PMo4V8O40 (AgPMo4V8) comprised uniform nanoparticles of 50 nm size, which provided significant catalytic oxidative desulfurization (CODS) performance using O2, N2 + O2 or air as an oxidant. The high efficiency of 100% removal was obtained using AgPMo4V8 nanoparticles as a catalyst in treating model refractory sulfurs. The coexistence of Ag+ and PMo4V8O4011- was the main contribution for this CODS procedure, and the Ag+ species was employed as the electron transfer mediator (ETM) and the PMo4V8O4011- anion was used as the electron donor. The internal electron transfer between Ag+/Ag0 and V5+/V4+ allowed AgPMo4V8 to mimic oxygenase to release the activation energy of oxygen. AgPMo4V8 nanoparticles also exhibited potential for practical catalytic application in the CODS of diesel and gasoline to produce ultra-clean oils with a S content lower than 10 ppm under mild reaction conditions using a mixture of N2 and O2, thus favoring industrial application.
