[Effect of nitrobenzene and its chlorine derivatives on antioxidative homeostasis]. / Vplyv nitrobenzolu ta ioho khlorpokhidnykh na antyokysliuvalnyi homeostaz.

Nitrobenzene, o-nitrochlorobenzene and p-nitrochlorobenzene were studied in experiments with rats for their effect on intensity of lipid peroxidation (LPO), antioxidative activity (AOA), vitamin E content in the spleen and liver tissues as well as on certain hematological parameters of animals. These substances, when applied in acute experiments, deteriorate hematological parameters, intensify LPO in the spleen tissues. In this case AOA and vitamin E concentration grow. Subchronic action promotes stabilization of the studied parameters, which testifies to active adaptation of the organism to action of the above xenobiotics, as well as to high significance of the antioxidative homeostasis regulation system in the process.

[Protective effect of vitamin E in acute administration of nitrobenzene and its chlorine derivatives into the stomach of rats]. / Zakhystna diia vitaminu E pry hostromu vvedenni nitrokhlorbenzolu ta ioho khlorpokhidnykh u shlunok shchuriv.

The level of lipid peroxidation, content of vitamin E and its metabolites as well as antioxidative activity in the blood serum, liver and spleen of white rats were studied. Toxicological effects of nitrobenzene and nitrochlorbenzenes were decreased by vitamin E.