Anxiety and neural correlates of attention and self-regulation in pregnancy: a resting-state EEG study.

PURPOSE: Pregnant women are particularly vulnerable to experiencing mental health difficulties, especially anxiety. Anxiety in pregnancy can be characterized as having two components: general symptomology experienced in the general population, and pregnancy-related anxiety more focused on pregnancy, delivery, and the future child. In addition, women also commonly report experiencing attentional control and self-regulation difficulties across the peripartum period. However, links between anxiety and neural and cognitive functioning in pregnancy remain unclear. The present study investigated whether anxiety is associated with neural markers of attention and self-regulation measured using electroencephalography (EEG). Specifically, we examined associations between general and pregnancy-related anxiety and (1) beta oscillations, a neural marker of attentional processing; and (2) the coupling of beta and delta oscillations, a neural marker of self-regulation, in frontal and prefrontal regions. METHODS: A sample of 135 women in the third trimester of their pregnancy completed a resting-state EEG session. RESULTS: General anxiety was associated with increased beta oscillations, in line with research in the general population, interpreted as reflecting hyperarousal. Pregnancy-related anxiety was associated with decreased beta oscillations, interpreted as reflecting inattention and mind-wandering. Moreover, pregnancy-related anxiety, but not general anxiety, was linked to stronger delta-beta coupling, suggesting anxiety specifically related to the pregnancy is associated with investing greater effort in self-regulation. CONCLUSION: Our results suggest that general and pregnancy-related anxiety may differentially relate to neural patterns underlying attention and self-regulation in pregnancy.

Emotion regulation strategies and perceived stress during pregnancy in expectant mothers and fathers.

BACKGROUND: Stress during pregnancy can increase physical and mental health risks in parents and offspring. Emotion regulation (ER) may protect against prenatal stress; however, ER is understudied in expectant parents, particularly expectant fathers. This study aimed to evaluate associations between ER strategies (reappraisal, suppression, ratio of suppression-to-reappraisal) and perceived stress among expectant parents, and also test whether expectant mothers and fathers differed in ER strategy use and perceived stress levels. METHODS: N = 83 expectant parents (62.7% mothers) in the third trimester completed measures assessing perceived stress,reappraisal, and suppression. ANCOVA, hierarchical regression, and multilevel models were used to evaluate associations between ER strategies and perceived stress, and test for sex differences. RESULTS: Controlling for age and education, lower reappraisal and higher suppression were associated with higher perceived stress; in addition, higher suppression-to-reappraisal ratios were associated with greater perceived stress. Mothers and fathers did not differ in perceived stress, reappraisal, or suppression; however, suppression-to-reappraisal ratios significantly differed. CONCLUSION: Increasing ER skills such as reappraisal while reducing suppression may be beneficial for decreasing stress in expectant parents. Expectant fathers report similar levels of perceived stress to mothers and would benefit from prenatal mental health screening and intervention.

The effects of prenatal stress on neural responses to infant cries in expectant mothers and fathers.

The perinatal period is characterized by distinct neurobiological and psychological changes initiated prenatally, which may both facilitate postpartum caregiving and increase vulnerability to stress. Parents need to adapt to the high demands of caregiving, which include responding to salient infant cues, such as infant cries. Therefore, assessing the impact of prenatal stress exposure on parents' neural processing of infant cries may elucidate mechanisms conferring early risk for detrimental perinatal outcomes. Using event-related potentials, we examined whether prenatal perceived stress affected neural markers of perceptual (N1, P2) and attentional (LPP) processes elicited by high- and low-distress infant cries in expectant mothers (n = 38) and fathers (n = 30). Results evidenced that prenatal perceived stress impacted parents' sustained attentional processing (LPP) of infant cries, but not early perceptual responses (N1, P2). Specifically, higher levels of prenatal perceived stress were associated with a greater LPP response to low-distress, but not high-distress, infant cries. There were no parental sex differences in prenatal perceived stress or neural responses to infant cries. Increased attentional processing of low-distress cries in highly stressed parents may reflect uncertainty regarding infant distress level, thereby requiring more attentional resources. Overall, our results suggest that prenatal stress impacts processing of infant cues, even before birth.

Maternal perinatal anxiety and neural responding to infant affective signals: Insights, challenges, and a road map for neuroimaging research.

Anxiety symptoms are common among women during pregnancy and the postpartum period, potentially having detrimental effects on both mother and child's well-being. Perinatal maternal anxiety interferes with a core facet of adaptive caregiving: mothers' sensitive responsiveness to infant affective communicative 'cues.' This review summarizes the current research on the neural correlates of maternal processing of infant cues in the presence of perinatal anxiety, outlines its limitations, and offers next steps to advance future research. Functional neuroimaging studies examining the neural circuitry involved in, and electrophysiological studies examining the temporal dynamics of, processing infant cues during pregnancy and postpartum are reviewed. Studies have generally indicated mixed findings, although emerging themes suggest that anxiety may be implicated in several stages of processing infant cues- detection, interpretation, and reaction- contingent upon cue valence. Limitations include inconsistent designs, lack of differentiation between anxiety and depression symptoms, and limited consideration of parenting-specific (versus domain-general) anxiety. Future studies should incorporate longitudinal investigation of multiple levels of analysis spanning neural, cognitive, and observed aspects of sensitive caregiving.

Imagining the baby: Neural reactivity to infant distress and mind-mindedness in expectant parents.

Neural and psychological processes in pregnancy may be important antecedents for caregiving postpartum. Employing event-related potentials, we examined neural reactivity to infant emotional faces during the third trimester of pregnancy in expectant mothers (n = 38) and expectant fathers (n = 30). Specifically, expectant parents viewed infant distress and infant neutral faces while electroencephalography was simultaneously recorded. As a psychological measure, we assessed prenatal mind-mindedness towards the unborn child and examined whether neural processing of infant cues was associated with levels of mind-mindedness. Expectant fathers evidenced greater P300 reactivity to infant distress, relative to neutral, faces than expectant mothers. Furthermore, P300 reactivity to infant distress, relative to infant neutral, faces was associated with levels of prenatal mind-mindedness in expectant fathers but not expectant mothers. These findings indicate significant sex differences in the prenatal neural processing of infant cues and relations between neural reactivity to infant distress and the emergence of parental mind-mindedness.

Prior reproductive experience modulates neural responses to infant faces across the postpartum period.

Infant-cue processing facilitates sensitive maternal care, which is necessary in the formation of healthy mother-infant attachment. Mothers may be particularly focused on cue processing early postpartum, contributing to intense preoccupation with their infant's well-being. Prior reproductive experience, or parity, may also impact the intensity of infant-cue processing and has been found to influence P300 neural responses to infant faces during pregnancy and at 2 months postpartum. However, we do not know whether this parity effect persists. Thus, we examined the P300 to infant faces in 59 mothers at 2 and 7 months postpartum. Our main finding was that primiparous, as compared to multiparous, women showed a significantly higher P300 to infant faces across the postpartum period. Findings further emphasize the importance of studying parity and its impact on the neural processing of infant faces.

Facial recognition during early motherhood: Investigating the persistence of age and affect biases.

Converging evidence demonstrates increased levels of sensitivity to infant faces in mothers. This may be reflective of a series of psychological and neurobiological changes that occur in the transition to, and during early, parenthood for the purpose of appropriate caregiving; however, this enhanced infant facial recognition is in contrast with the general adult literature regarding facial processing. In the current study, we aimed to replicate a prior study of emotion facial recognition in pregnant women in a sample of mothers with children under a year old, utilizing a paradigm in which adult and infant faces gradually changed from neutral expressions to either happy or sad expressions. Mothers were faster at the recognition of adult faces in comparison to infant faces, and were also faster at happy faces in comparison to sad faces. Results are discussed in context of the current processing literature regarding the perinatal period, and implications for the persistence of the own-age bias and happy face advantage are considered.