[Incidence of antibodies against hepatitis virus A (anti-HA) in a non-selected urban population]. / Frecventa anticorpilor fata de virusul hepatitei A (anti-HA) într-o populatie urbana neselectata.

Anti-HA antibodies were determined by radioimmunoassay according to the HAVAB-ABBOTT technique in 244 subjects, of whom 194 without hepatic involvement, 25 with non B hva and 25 former non B hva patients. Anti-HA anti-bodies were found in 67% of the healthy subjects and 100% of the patients and former hva cases. The incidence of anti-HA antibodies increases with age being in 30% of children and 83.5% of adults. A peak incidence was found between the ages 21 and 30 years. In the district investigated subclinical infection with HVA was frequent, beginning in childhood and up to the age of 30 years. The qualitative HAVAB test is adequate for epidemiological investigations; a quantitative variant is necessary for the diagnosis.

[Frequency and prognostic value of the "e" system in hepatitis B virus infection]. / Frecventa si valoarea prognostica a sistemului "e" în infectia cu virusul hepatic B.

The frequency and prognostic value of the "e" system was determined in acute and chronic hepatitis patients and in blood donors by immunodiffusion on Abott rheophoresis plates. The incidence of HBe Ag in acute viral hepatitis was 20% at the beginning of the disease; its persistance indicated a prolonged evolution and a tendency to a chronic course. The presence of anti-HBe at the beginning of the acute disease may indicate the onset of a non-B hepatitis in an HBe carrier. In chronic hepatitis the incidence of HBe Ag was 58% and in blood donors only 6%. Anti-HBe was absent in chronic hepatitis and present in 15% of blood donors.

[Incidence and duration of blood HBs antigen in convalescents after type B viral hepatitis]. / Antigenemia HBs ca frecventa si durata la convalescentii de hepatita virala tip B.

The presence of HBs Ag was determined by contraelectrophoresis in 500 convalescents after hepatitis B, at the moment of discharge and after 1--3 and 6 months. Antigen carriage is prolonged in hepatitis B, 51% of the convalescents being positive on discharge and 10% remaining persistent carriers. This was more frequent in males, young adults and those who had suffered from mild, prolonged forms of the disease. As only 42% of the patients became negative within the first 20 days of hospitalization it became necessary to prolong their stay in hospital and to follow up the patients subsequently in an out-patient unit.

[Current aspects of infectious mononucleosis]. / Aspecte actuale în mononucleoza infectioasa

The authors discuss present aspects in infectious mononucleosis, with reference to the cases admitted to the Clinic of communicable Diseases of Cluj-Napoca, i.e. 115 cases during the 1954--1973 period (3 to 13 cases a year). In most cases the clinical symptomatology was mild and the laboratory tests typical not giving rise to any diagnostic difficulties. However, 28 cases (25%) presented jaundice, with positive hepatic tests, so that a differential diagnosis was established with viral hepatitis. In 9 cases nervous manifestations were reported: 4 encephalitis, 1 neuritis of the hypoglossal nerve, 2 facial paralysis, 2 benign serous meningitis cases, all of which fully recovered. The Paul Bunnel-Hanganutiu test was positive in titers of 1 : 40 -- 1 : 1280, in all the cases. Corticotherapy was applied with good results in 24 cases. All the cases ran a favourable course. On admission, 45% of the patients came with a diagnosis of infectious mononucleosis; the others were admitted with a diagnosis of : diphteric angina, viral hepatitis, influenza, German measles, mups, typhoid fever, prolonged febrile syndrome.