First case of deep neck and descending mediastinal abscess caused by dentoalveolar Eggerthia catenaformis infection.

Descending mediastinal abscesses arising from oral (dental or peritonsillar abscess) or deep neck infections (DNIs) often become fatal without surgical drainage. Odontogenic origin was the most common cause of DNIs. We report the first clinical case of a patient with descending mediastinal abscess caused by DNI from Eggerthia catenaformis a Gram-positive anaerobic rod that can be rarely a human pathogen. The patient underwent the extraction of carious molars, cervical and thoracic surgical drainage, and targeted antibiotic therapy with resolution of the infection.

Snoring patterns during home polysomnography. A proposal for a new classification.

PURPOSE: Snoring is a very common disorder, but, at present, there is no universally accepted classification for the condition. The main aim of this paper is to introduce a home sleep monitoring-based classification of common snoring patterns in simple snorers and in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). MATERIALS AND METHODS: In total, 561 consecutive patients with a history of snoring, either simple or associated with apnea, were enrolled in this home sleep monitoring study. Analysis of the polysomnographic traces and the snoring sensor allowed the main patterns of snoring and their characteristics to be determined. RESULTS: Four patterns of snoring were identified. In a spectrum of increasing severity (mild, moderate or severe), snoring can be episodic, positional, continuous, or alternating, whereas in obstructive sleep apnea syndrome, the snoring events only occur between successive respiratory obstructive events. In mild snoring, the episodic pattern is the most frequent, whereas in moderate and severe snoring, the continuous snoring pattern occurs in most cases. CONCLUSIONS: The proposed classification of snoring patterns would be beneficial for providing a realistic disturbance index, for the selection and evaluation of the outcomes of surgical techniques.

Singing voice: acoustic parameters after vocal warm-up and cool-down.

Purpose: The aim of this study was to evaluate the effect of the vocal warm-up and cool-down on the singing voice through Fundamental Frequency (F0), Jitter, Shimmer and harmonics-to-noise ratio (HNR).Methods: Thirty-two female singing students were recorded four times while uttering the vowel [a] for at least 5''. The first two recordings were collected before and after a vocal warm-up session and the last two before and after a vocal cool-down session. Between those sessions the participants underwent an intense vocal activity.Results: Results showed significant variations in the average values of the parameters measured. The mean value of the F0 after intense vocal activity turned to be higher than the one measured before the warm-up session, as well as the mean F0 measured after singing compared to the one measured after the vocal warm-up. On the other end, the mean F0 after the vocal cool-down resulted to be lower than that measured before. After the vocal warm-up session Jitter and Shimmer decreased while HNR increased. In addition, a decrease was detected in comparison with the average value of Jitter and Shimmer before vocal warm-up and after vocal cool-down, whereas HNR increased. There was also a decrease between the Shimmer before the vocal warm-up and after an intense phonatory activity while HNR increased.Conclusions: Our study highlights the effect of the vocal warm-up on acoustic parameters. The reduction in F0 observed after the cool-down session confirms its positive effect in helping professional vocal recovery and reducing vocal fold tension.

Outcomes in single-stage multilevel surgery for obstructive sleep apnea: Transoral robotic surgery, expansion sphincter pharyngoplasty and septoplasty.

BACKGROUND: Many patients with obstructive sleep apnea syndrome (OSAS) have multiple obstructive sites simultaneously such as the oropharynx, hypopharynx, and larynx. Multilevel surgery is starting to be widely performed by ENT surgeons and accepted by patients. METHODS: Twenty consecutive patients with moderate or severe OSAS were treated with single-stage multilevel surgery. They underwent transoral robotic surgery for tongue base reduction or epiglottoplasty, expansion sphincter pharyngoplasty, and septoplasty. RESULTS: The average length of hospitalization was 5.2 ± 0.9 days. No serious complications were observed. At the postoperative control with polysomnography, the apnea-hypopnea index (AHI) had decreased by at least 50% in 90% of patients; improvements were observed in all sleep parameters. CONCLUSION: Single-stage multilevel surgery has proven to be effective in treating patients with moderate to severe OSAS, without experiencing persistent complaints. Despite multiple levels of obstruction being operated in a single stage, airway safety was maintained in all patients.

Underwater Acoustic Source Localisation Among Blind and Sighted Scuba Divers: Comparative study.

OBJECTIVES: Many blind individuals demonstrate enhanced auditory spatial discrimination or localisation of sound sources in comparison to sighted subjects. However, this hypothesis has not yet been confirmed with regards to underwater spatial localisation. This study therefore aimed to investigate underwater acoustic source localisation among blind and sighted scuba divers. METHODS: This study took place between February and June 2015 in Elba, Italy, and involved two experimental groups of divers with either acquired (n = 20) or congenital (n = 10) blindness and a control group of 30 sighted divers. Each subject took part in five attempts at an under-water acoustic source localisation task, in which the divers were requested to swim to the source of a sound originating from one of 24 potential locations. The control group had their sight obscured during the task. RESULTS: The congenitally blind divers demonstrated significantly better underwater sound localisation compared to the control group or those with acquired blindness (P = 0.0007). In addition, there was a significant correlation between years of blindness and underwater sound localisation (P <0.0001). CONCLUSION: Congenital blindness was found to positively affect the ability of a diver to recognise the source of a sound in an underwater environment. As the correct localisation of sounds underwater may help individuals to avoid imminent danger, divers should perform sound localisation tests during training sessions.

Neck epidermoid cyst mimicking tuberculosis at ultrasound: Case report and review of literature.

Neck masses in children can be inflammatory, congenital or neoplastic. When a congenital cyst becomes infected repeatedly, it may mimic inflammatory disease and the diagnosis may be challenging with ultrasound. An increasing incidence of infection with non-tuberculous mycobacterial organisms has been observed in recent decades in children with cervical lymphadenopathy. An ultrasound scan performed during the infectious phase of a mass can be misleading and can lead to an incorrect diagnostic hypothesis with the risk of erroneous medical and surgical therapies. We describe a case of a lateral neck epidermoid cyst mimicking and misdiagnosed as a tuberculous lymphadenopathy at ultrasound scan and treated with primary surgical excision. After surgery, a histological diagnosis of an epidermal cyst was made. There were no signs of recurrence during the 12-month follow-up period. A review of the literature and a proposed practice pathway for lateral cervical lymphadenopathy in children is also reported.

Iron supplement tablet embedded in the oral cavity mimicking neoplasm: a case report.

The detection of foreign bodies in the upper-aerodigestive tract is a fairly frequent event and can occur in various areas and for various reasons. In rare cases, foreign bodies can simulate a neoplasia. We evaluated similar cases during emergency regimen with an oral cavity mucosal lesion, causing lockjaw, sore throat, dysphagia, and swelling of the submandibular and laterocervical region. Physical examination revealed an extensive mucosal ulceration in the floor of the mouth and the lateral surface of the tongue, comparable to oral cancer. During a second, more accurate assessment, a partially deteriorated iron supplement tablet was found embedded in a mucosal pocket. After removing the tablet, gradual normalization of the tissue was observed without any sequelae. This is one of the many reasons why it is advisable and useful in cases of oral lesions to collect a detailed medical history and to perform an accurate clinical evaluation, including inspection and palpation of the lesion, before proceeding to further diagnostic assessments, especially in elderly patients taking many medications. However unlikely, it is possible that difficulty in swallowing pills or tablets could generate tumorlike lesions.

A survey on chronic rhinosinusitis: opinions from experts of 50 countries.

Chronic rhinosinusitis (CRS) is a very prevalent inflammatory disease. Treatments vary in different countries. In the present study, we explored the approaches of physicians in 50 countries. In this cross-sectional study, a rhinosinusitis survey (RSS) was completed by Honorary and Corresponding Members (otorhinolaryngologists) of the Italian Society of Rhinology. In 79.1 % of the 50 countries, the proportion of patients suffering from CRS was 15 %. Nasal symptoms were more intense in winter (46 % of countries), and spring and autumn (22 %). The most common symptoms were nasal obstruction (86 %), postnasal drip (82 %) and headache (52 %). The most common investigative modalities in the assessment of CRS are paranasal sinus CT, fiberoptic endoscopy, and anterior rhinoscopy. CRS patients were principally treated by otorhinolaryngologists (70 %). Medical treatments included nasal corticosteroids (90 %), nasal washes (68 %), and nasal decongestants (32 %). In 88 % of countries, more than 50 %, or "about 50 %", of all patients reported subjective symptom improvement after treatment. In most of the countries, surgery was required by 20-35 % of all CRS patients. During post-surgery follow-up, nasal washes (90 %), nasal corticosteroids (76 %), and systemic antibiotics (32 %) were prescribed. In 20-40 % of all patients, CRS was associated with nasal polyps. In such patients, the medical treatment options were nasal corticosteroids (90 %), systemic corticosteroids (50 %), nasal washes (46 %), and systemic antibiotics (34 %). Treatment of CRS patients varies in different countries. Paranasal sinus CT is the most common investigative modality in the assessment of CRS, and nasal corticosteroids are the first-line treatment, in the absence or presence of nasal polyps.

Effects of a Mask on Breathing Impairment During a Fencing Assault: A Case Series Study.

BACKGROUND: Fencers often complain of progressive difficulty in breathing during matches, which is generally attributed to restricted air, light and heat circulation from wearing a mask. Physiologically, the nasal structure generates airflow resistance that can reach -50% of the total respiratory resistance. OBJECTIVES: This study aims to investigate the presence of nasal obstruction in fencers and the relationship with the use of mask. MATERIALS AND METHODS: An observational study on 40 fencers (18 males, 22 females) was conducted. Fencers perform a usual assault, wearing the mask and standardized physical exercises (running, sprints and obstacles) without the mask. ENT examination with a nasal flexible fiberscope, Anterior Active Rhinomanometry (AAR) and Peak Nasal Inspiratory Flow (PNIF) measurement before and after physical activity with or without the mask was recorded. RESULTS: Before physical exercise, the total nasal airway resistance mean value for AAR was 0.33 ± 0.17 Pa/cm(3)/s at 150 Pa. After a match with the mask, the mean value was 0.28 ± 0.16 Pa/cm(3)/s. After normal physical exercises without mask, the mean value was 0.24 ± 0.15 Pa/cm(3)/s. Using t tests, statistically significant difference between nasal resistance before and after physical activity (P < 0.05) was observed, but no significant difference in nasal resistance between the basal value and that taken after a match wearing the masks (P = 0.1265). PNIF values significantly increase with exercise (P < 0.05). CONCLUSIONS: Our study shows that wearing the mask causes increased breathing impairment in fencers, when compared with similar physical activity without the mask.

Changes in ghrelin, leptin and pro-inflammatory cytokines after therapy in Obstructive Sleep Apnea Syndrome (OSAS) patients.

INTRODUCTION: The correlations between the levels of cytokines, apnea, and obesity are not well understood. The aim of this study was to investigate the relationship between sleep apnea, body mass index (BMI) and plasma levels of leptin, ghrelin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). MATERIALS AND METHODS: Levels of leptin, ghrelin, IL-6, and TNF-α were compared in 20 obese (BMI > 30 kg/m²) and 6 non-obese patients (BMI < 27 kg/m²) with Obstructive Sleep Apnea Syndrome (OSAS), and in 13 obese and 11 non-obese control subjects without OSAS. All patients were investigated with Polysomnography (PSG) and ENT examination with flexible endoscopy and Müller's maneuver. Twelve patients were treated with continuous positive airway pressure (CPAP) and 14 with surgery. Fasting leptin, ghrelin and cytokine levels were measured at baseline, 2 days and 6 months after initiation of CPAP treatment, and 6 months after surgery. RESULTS: Leptin, ghrelin and cytokine levels did not change significantly from baseline after 2 days of CPAP. After 6 months of CPAP or surgery, leptin, IL-6, and TNF-α levels were decreased in all OSAS patients. No difference in ghrelin levels was observed. DISCUSSION: Elevated leptin levels are not determined by obesity alone, since they decreased with Apnea Hypopnea Index reduction. Higher pro-inflammatory cytokine basal levels observed in patients with OSAS were not correlated with BMI.

Activity of coenzyme Q 10 (Q-Ter multicomposite) on recovery time in noise-induced hearing loss.

A potential consequence of exposure to noise is a temporary reduction in auditory sensitivity known as temporary threshold shift (TTS), which mainly depends on the intensity and duration of exposure to the noise. Recovery time is related to the amount of initial hearing loss, and the most recovery takes place during the first 15 min following exposure. This study evaluated the efficacy in otoprotection against noise-induced hearing loss of an orally administrated food supplement containing coenzyme Q 10 -Ter. This water-soluble formulation of coenzyme Q 10 shows better bioavailability than the native form and has been found to have a protective effect on outer hair cells after exposure to noise in animal models. Thirty volunteers were enrolled, and the right ear of each subject was exposed to a narrow-band noise centered at 3 kHz for 10 min at the intensity of 90 dB HL. In the 30 subjects enrolled, TTS was evaluated after 2, 15, and 30 min and the recovery time was recorded in each subject. The longest recovery time was 45 min. Among the 18 subjects who underwent a second test after treatment with Q-Ter, the mean recovery time was 31.43 min. The results of the present study show that 30 days' treatment with Q-Ter can aid faster recovery after exposure to noise (P < 0.0001). The reduction in the recovery time following treatment can be explained by Q-Ter-mediated improvement of the outer hair cells' response to oxidative stress.

PLUNC proteins positivity in patients with chronic rhinosinusitis: a case-control study.

INTRODUCTION: Innate immunity is the first protection against microorganisms. Nowadays, there is a growing interest in innate immune molecule known as palate, lung, nasal epithelial clone (PLUNC). PLUNC is a specific product of the airways, of approximately 25 kDa, encoded by adjacent genes found within a 300 kb region of chromosome 20; these proteins must be detected predominantly in the upper respiratory tract. MATERIALS AND METHODS: We performed a case-control study to investigate the presence of this protein in nasal tissue of patients affected by chronic rhinosinusitis. 59 patients were enrolled (44 cases, 15 controls). We have examined the correlation between the presence of pathology and the PLUNC proteins positivity. RESULTS: 100% of controls have a +++ rated PLUNC proteins positivity, while cases have a lower percentage of positivity. We used χ (2) statistical test to analyze the results of the study and there is a difference statistically significant between cases and controls in PLUNC proteins positivity. CONCLUSIONS: These observations suggest that, in response to agents or chemical factors, nasal mucosal epithelium will react and produce PLUNC proteins. So PLUNC proteins have a protective function on upper airways mucosa, as we can see by evaluating the high positivity in control group.

Communication skills and thalamic lesion: Strategies of rehabilitation.

AIM: To describe the speech rehabilitation history of patients with thalamic lesions. BACKGROUND: Thalamic lesions can affect speech and language according to diverse thalamic nuclei involved. Because of the strategic functional position of the thalamus within the cognitive networks, its lesion can also interfere with other cognitive processes, such as attention, memory and executive functions. Alterations of these cognitive domains contribute significantly to language deficits, leading to communicative inefficacy. This fact must be considered in the rehabilitation efforts. MATERIALS AND METHODS: Whereas evaluation of cognitive functions and communicative efficiency is different from that of aphasic disorder, treatment should also be different. The treatment must be focused on specific cognitive deficits with belief in the regaining of communicative ability, as well as it occurs in therapy of pragmatic disorder in traumatic brain injury: attention process training, mnemotechnics and prospective memory training. RESULTS: According to our experience: (a) there is a close correlation between cognitive processes and communication skills; (b) alterations of attention, memory and executive functions cause a loss of efficiency in the language use; and (c) appropriate cognitive treatment improves pragmatic competence and therefore the linguistic disorder. CONCLUSION: For planning a speech-therapy it is important to consider the relationship between cognitive functions and communication. The cognitive/behavioral treatment confirms its therapeutic efficiency for thalamic lesions.

Congenital mucocele of the tongue: a case report and review of the literature.

Mucoceles are benign lesions of the oral cavity that develop as a result of retention or extravasation of mucous material from minor salivary glands. Congenital mucoceles are very rare. These lesions in newborns may interfere with breastfeeding and may even compromise respiratory function. A patient with a congenital mucocele diagnosed by prenatal ultrasound screening showing a cystic lesion of the tongue is presented herein. The physical examination, lesion evolution and imaging are described, together with the surgical management, histopathology and two-year follow-up. Early clinical assessment, differential diagnosis and magnetic resonance imaging allow clinicians to diagnose and treat this rare congenital condition with surgery in early infancy.

Role of adenotonsillectomy in OSAS children and behavioural disturbance.

AIM: The main aim of this study was to assess the presence of behavioural disturbances in child with OSAS before and after adenotonsillectomy (AT). BACKGROUND: In children adenotonsillar hypertrophy is associated with increased probability of OSAS. Children with OSAS present neurobehavioral disorders like attention deficit and hyperactivity, learning disabilities and daily attitudes due to excessive sleepiness. MATERIALS AND METHODS: 195 consecutive young patients suffering from OSAS and recurrent throat infections (control group) underwent AT. All underwent clinical evaluation, polysomnography, Behaviour Assessment System for Children questionnaire (BASC-2), for parents evaluation of behavioural disturbances and nasal functionality tests (before and 6 months after surgery). RESULTS: Snoring and nocturnal apnoea were no more present in almost all. In OSAS group before AT 12 children were normal, 4 children were borderline and 2 were clinically significant at the BASC-2. After AT 16 children were normal, 2 children were borderline and none was clinically significant according to the same questionnaire. In the control group 9 children were normal and 1 was borderline both before and after AT. CONCLUSION: Adenoids/tonsils hypertrophy and nasal hypoventilation are frequent causes of snoring and OSAS. AT improves significantly both snoring/apnoeas and OSAS children's behavioural disturbances. Polysomnography cannot be carried out routinely due to the lack of specialised centres and because of its excessive cost. Nasal functionality tests can be useful for the differential diagnosis between sleep apnoea syndrome and other noises.

Functional maturation of nasal mucosa: role of secretory immunoglobulin A (SIgA).

Secretory IgA (SIgA) plays an important role in defending the mucous membranes of the upper respiratory airways from common infection. Studying and comparing the values and the daily variation of SIgA in nasal secretion could explain the largest number of upper respiratory infection, especially in children.Moreover, the ELISA dosage of SIgA in nasal secretion, sampled by cotton swabs positioned between septum and middle turbinate for 20 minutes every 4 hours 5 times in a day, can be easily performed and shows significant differences between the healthy child and the healthy adult.Nasal secretion SIgA mean value is lower in the healthy child than in the healthy adult. Circadian variation for healthy child showed the highest value at 7.00 a.m., while in adult the highest value was at 4.00 a.m.These knowledge on SIgA may help to explain the highest number of upper airway infection during childhood and clarify the physiological cycle of production. Thus, in performing a SIgA dosage the time of sample must be considered and preferably it should be made at a standardized time of the day.