Shift happens: aging alters the content but not the organization of memory for complex events.

While cognitive aging research has compared episodic memory accuracy between younger and older adults, less work has described differences in how memories are encoded and recalled. This is important for memories of real-world experiences, since there is immense variability in which details can be accessed and organized into narratives. We investigated age effects on the organization and content of memory for complex events. In two independent samples (N = 45; 60), young and older adults encoded and recalled the same short-movie. We applied a novel scoring on the recollections to quantify recall accuracy, temporal organization (temporal contiguity, forward asymmetry), and content (perceptual, conceptual). No age-effects on recall accuracy nor on metrics of temporal organization emerged. Older adults provided more conceptual and non-episodic content, whereas younger adults reported a higher proportion of event-specific information. Our results indicate that age-related differences in episodic recall reflect distinctions in what details are assembled from the past.

Time spent imagining does not influence younger and older adults' episodic simulation of helping behavior.

Shared cognitive processes underlie our ability to remember the past (i.e., episodic memory) and imagine the future (i.e., episodic simulation) and age-related declines in episodic memory are also noted when simulating future scenarios. Given older adults' reduced cognitive control and protracted memory retrieval time, we examined whether imposing time limits on episodic simulation of future helping scenarios affects younger and older adults' willingness to help, phenomenological experience, and the type of details produced. Relative to a control task, episodic simulation increased younger and older participants' willingness to help, scene vividness, and perspective-taking regardless of the time spent imagining future helping scenarios. Notably, time spent imagining influenced the number, but not proportion of internal details produced, suggesting that participants' use of episodic-like information remained consistent regardless of the time they spent imagining. The present findings highlight the importance of collecting phenomenological experience when assessing episodic simulation abilities across the lifespan.

Some young adults hyper-bind too: Attentional control relates to individual differences in hyper-binding.

Hyper-binding - the erroneous encoding of target and distractor information into associative pairs in memory - has been described as a unique age effect caused by declines in attentional control. Previous work has found that, on average, young adults do not hyper-bind. However, if hyper-binding is caused by reduced attentional control, then young adults with poor attention regulation should also show evidence of hyper-binding. We tested this question with an individual differences approach, using a battery of attentional control tasks and relating this to individual differences in hyper-binding. Participants (N = 121) completed an implicit associative memory test measuring memory for both target-distractor (i.e., hyper-binding) and target-target pairs, followed by a series of tasks measuring attentional control. Our results show that on average, young adults do not hyper-bind, but as predicted, those with poor attentional control show a larger hyper-binding effect than those with good attentional control. Exploratory analyses also suggest that individual differences in attentional control relate to susceptibility to interference at retrieval. These results support the hypothesis that hyper-binding in older adults is due to age-related declines in attentional control, and demonstrate that hyper-binding may be an issue for any individual with poor attentional control, regardless of age.

Episodic simulation of helping behavior in younger and older adults during the COVID-19 pandemic.

Imagining helping a person in need increases one's willingness to help beyond levels evoked by passively reading the same stories. We examined whether episodic simulation can increase younger and older adults' willingness to help in novel scenarios posed by the COVID-19 pandemic. Across 3 studies we demonstrate that episodic simulation of helping behavior increases younger and older adults' willingness to help during both everyday and COVID-related scenarios. Moreover, we show that imagining helping increases emotional concern, scene imagery, and theory of mind, which in turn relate to increased willingness to help. Studies 2 and 3 also showed that people produce more internal, episodic-like details when imagining everyday compared to COVID-related scenarios, suggesting that people are less able to draw on prior experiences when simulating such novel events. These findings suggest that encouraging engagement with stories of people in need by imagining helping can increase willingness to help during the pandemic.

Effect of situation similarity on younger and older adults' episodic simulation of helping behaviours.

Similar cognitive processes enable us to remember the past (i.e., episodic memory) and simulate future events (i.e., episodic simulation). In the current study, we demonstrate an important role for previous experience when younger and older adults simulate future behaviours. Participants read short descriptions of a person in need of help in scenarios that were more familiar to either younger or older adults (e.g., dealing with dating apps vs writing a cheque). Participants either imagined helping the person or thought about the style of the story (control task), and then rated their willingness to help, scene vividness, emotional concern, and subjective use of theory of mind. Hierarchical mixed effect modelling revealed that both episodic simulation and one's previous experience increased willingness to help, in that participants were more willing to help if they imagined helping and the situation was more familiar to them. Further, in simulated scenarios the relationship between previous experience and willingness to help was mediated by scene vividness and perspective-taking in younger adults, but only by perspective-taking in older adults. Taken together, these findings suggest that situation similarity and episodic simulation increase willingness to help, possibly via different mechanisms in younger and older adults.

Reduced distinctiveness of event boundaries in older adults with poor memory performance.

We experience the world as a continuous flow of information but segment it into discrete events in long-term memory. As a result, younger adults are more likely to recall details of an event when cued with information from the same event (within-event cues) than from the prior event (between-event cues), suggesting that stronger associations are formed within events than across event boundaries. The present study aimed to investigate the effects of age and working memory updating on this within > between cued-recall effect and the consequences for subsequent memory. Across two studies, participants viewed two different films (Hitchcock's Bang You're Dead and BBC's Sherlock). They were later shown clips taken from either the beginning/middle (within-event cues) or end (between-event cues) of a scene and asked to recall what happened next in the film. While the main effect of age was not significant in either experiment, overall memory performance related to the within > between effect in older, but not younger, adults. Low-performing older adults showed less of a difference in cued recall for within- and between-event cues than high performers. In Study 2, better two-back task performance also related to a greater within > between effect in older, but not younger, adults, suggesting that working memory updating relates to the distinctiveness of events stored in long-term memory, at least in older adults. Taken together, these findings suggest that age differences in event memory are not inevitable and may critically depend on one's ability update working memory at event boundaries. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Rating the Honesty of White and Black Children via Implicit and Explicit Measures: Implications for Child Victims in the Criminal Justice System.

The present study explored implicit and explicit honesty perceptions of White and Black children and whether these perceptions predicted legal decisions in a child abuse case. Participants consisted of 186 younger and 189 older adults from the online Prolific participant pool. Implicit racial bias was measured via a modified Implicit Association Test and explicit perceptions through self-reports. Participants read a simulated legal case where either a Black or White child alleged physical abuse against their sports coach, and they rated the honesty of the child's testimony and rendered a verdict. Participants were implicitly biased to associate honesty with White children over Black children, and this bias was stronger among older adults. In the legal vignette, for participants who read about a Black child victim, greater implicit racial bias predicted less trust in the child's testimony and a lower likelihood of convicting the coach of abusing the child. In contrast to their implicit bias, participants self-reported Black children as being more honest than White children, suggesting a divergence in racial attitudes across implicit and explicit measures. Implications for child abuse victims are discussed.

Age differences in the use of positive and negative cues to filter distracting information from working memory.

Previous research has demonstrated that as people age, visual working memory (VWM) declines. One potential explanation for this decline is that older adults are less able to ignore irrelevant information, which contributes to VWM filtering deficits. Most research examining age differences in filtering ability has used positive cues (indicating which items to pay attention to), but negative cues (indicating which items to ignore) may be even harder for older adults to implement as some work suggests that negatively cued items are first paid attention to before they are suppressed. The current study aimed to test whether older adults can use negative cues to filter irrelevant information from VWM. Across two experiments, young and older adults were presented with two (Experiment 1) or four (Experiment 2) display items, preceded by a neutral, negative, or positive cue. After a delay, participants reported the target's orientation in a continuous-response task. Results show that both groups benefitted from being provided with a cue (positive or negative) compared to no cue (i.e., neutral condition), but the benefit was smaller for negative cues. Thus, although negative cues aid in filtering of VWM, they are less effective than positive cues, possibly due to residual attention being directed towards distractor items.

Trichophyton mentagrophytes complex: A retrospective study of 64 dogs from the Central United States (1997-2020).

BACKGROUND: There are limited clinical studies evaluating the Trichophyton mentagrophytes complex, with most reports confined to small case studies. Additionally, the studies are dated and provide limited information on response to newer or currently available therapies. HYPOTHESIS/OBJECTIVES: The aim of the study was to determine if there is a breed prevalence, lesion distribution and seasonality associated with the T. mentagrophytes complex for dogs evaluated in the central United States. An additional aim of the study was to evaluate response to therapies because there are minimal data available on clinical response with newer systemic antifungal drugs. ANIMALS: A total of 64 canine medical records were evaluated that had a previous diagnosis of T. mentagrophytes complex infection. MATERIALS AND METHODS: A retrospective study of medical records to evaluate signalment, time of onset of clinical signs, clinical presentation and therapeutic management. RESULTS: A higher incidence of T. mentagrophytes complex infection was observed in the American Kennel Club (AKC) Sporting group (43%) and Terrier group (20%). A seasonal influence was noted, with the onset of clinical signs being highest in October. Lesions most often affected the muzzle (48%), followed by the head excluding the pinnae (21%). Ketoconazole, itraconazole and terbinafine appeared equivalent as systemic therapeutic options to treat T. mentagrophytes complex infections. CONCLUSIONS AND CLINICAL RELEVANCE: This study identified patterns in breeds, seasonality and lesion distribution for the T. mentagrophytes complex in dogs from the central United States. Additionally, the study found several reasonable and reliable treatment options for systemic therapy.

Lifespan differences in visual short-term memory load-modulated functional connectivity.

Working memory is critical to higher-order executive processes and declines throughout the adult lifespan. However, our understanding of the neural mechanisms underlying this decline is limited. Recent work suggests that functional connectivity between frontal control and posterior visual regions may be critical, but examinations of age differences therein have been limited to a small set of brain regions and extreme group designs (i.e., comparing young and older adults). In this study, we build on previous research by using a lifespan cohort and a whole-brain approach to investigate working memory load-modulated functional connectivity in relation to age and performance. The article reports on analysis of the Cambridge center for Ageing and Neuroscience (Cam-CAN) data. Participants from a population-based lifespan cohort (N = 101, age 23-86) performed a visual short-term memory task during functional magnetic resonance imaging. Visual short-term memory was measured with a delayed recall task for visual motion with three different loads. Whole-brain load-modulated functional connectivity was estimated using psychophysiological interactions in a hundred regions of interest, sorted into seven networks (Schaefer et al., 2018, Yeo et al., 2011). Results showed that load-modulated functional connectivity was strongest within the dorsal attention and visual networks during encoding and maintenance. With increasing age, load-modulated functional connectivity strength decreased throughout the cortex. Whole-brain analyses for the relation between connectivity and behavior were non-significant. Our results give additional support to the sensory recruitment model of working memory. We also demonstrate the widespread negative impact of age on the modulation of functional connectivity by working memory load. Older adults might already be close to ceiling in terms of their neural resources at the lowest load and therefore less able to further increase connectivity with increasing task demands.

A partially nested cortical hierarchy of neural states underlies event segmentation in the human brain.

A fundamental aspect of human experience is that it is segmented into discrete events. This may be underpinned by transitions between distinct neural states. Using an innovative data-driven state segmentation method, we investigate how neural states are organized across the cortical hierarchy and where in the cortex neural state boundaries and perceived event boundaries overlap. Our results show that neural state boundaries are organized in a temporal cortical hierarchy, with short states in primary sensory regions, and long states in lateral and medial prefrontal cortex. State boundaries are shared within and between groups of brain regions that resemble well-known functional networks. Perceived event boundaries overlap with neural state boundaries across large parts of the cortical hierarchy, particularly when those state boundaries demarcate a strong transition or are shared between brain regions. Taken together, these findings suggest that a partially nested cortical hierarchy of neural states forms the basis of event segmentation.

Associations Between Atopic Dermatitis and Anxiety, Aggression, and Fear-Based Behaviors in Dogs.

The goal of this study was to determine if anxiety, aggression, and fear-related behaviors are more common in pruritic dogs with atopic dermatitis than nonpruritic, healthy dogs. One hundred forty-one pruritic dogs >1 yr of age with a clinical diagnosis of atopic dermatitis and a >3 mo history of pruritus were recruited. Dog owners completed a behavioral survey (canine behavioral assessment and research questionnaire) and a pruritus scale (pruritus visual analog scale). Pruritic, atopic dogs showed significant increases in fear- and anxiety-related behaviors as well as aggression compared with a large control group of healthy dogs. Stranger-directed aggression, owner-directed aggression, familiar-dog aggression, dog-directed fear, nonsocial fear, touch sensitivity, excitability, and attention-seeking behaviors were all increased in the study group. Trainability was decreased in the study group. Chronically pruritic dogs experience fear and anxiety and are more likely to display aggression. This is an important welfare issue for these animals. Early recognition of the behavioral derangements that can be associated with chronic pruritic skin disease could allow early intervention with a multidisciplinary approach for these patients, thus improving patient and owner quality of life and long-term treatment outcomes.

Increased alpha suppression with age during involuntary memory retrieval.

Recent work suggests that while voluntary episodic memory declines with age, involuntary episodic memory, which comes to mind spontaneously without intention, remains relatively intact. However, the neurophysiology underlying these differences has yet to be established. The current study used electroencephalography (EEG) to investigate voluntary and involuntary retrieval in older and younger adults. Participants first encoded sounds, half of which were paired with pictures, the other half unpaired. EEG was then recorded as they listened to the sounds, with participants in the involuntary group performing a sound localization cover task, and those in the voluntary group additionally attempting to recall the associated pictures. Participants later reported which sounds brought the paired picture to mind during the localization task. Reaction times on the localization task were slower for voluntary than involuntary retrieval and for paired than unpaired sounds, possibly reflecting increased attentional demands of voluntary retrieval and interference from reactivation of the associated pictures respectively. For the EEG analyses, young adults showed greater alpha event-related desynchronization (ERD) during voluntary than involuntary retrieval at frontal and occipital sites, while older adults showed pronounced alpha ERD regardless of intention. Additionally, older adults showed greater ERD for paired than unpaired sounds at occipital sites, likely reflecting visual reactivation of the associated pictures. Young adults did not show this alpha ERD memory effect. Taken together, these data suggest that involuntary memory is largely preserved with age, but this may be due to older adults' greater recruitment of top-down control even when demand for such control is limited.

The role of the arousal system in age-related differences in cortical functional network architecture.

A common finding in the aging literature is that of the brain's decreased within- and increased between-network functional connectivity. However, it remains unclear what is causing this shift in network organization with age. Given the essential role of the ascending arousal system (ARAS) in cortical activation and previous findings of disrupted ARAS functioning with age, it is possible that age differences in ARAS functioning contribute to disrupted cortical connectivity. We test this possibility here using resting state fMRI data from over 500 individuals across the lifespan from the Cambridge Center for Aging and Neuroscience (Cam-CAN) population-based cohort. Our results show that ARAS-cortical connectivity declines with age and, consistent with our expectations, significantly mediates some age-related differences in connectivity within and between association networks (specifically, within the default mode and between the default mode and salience networks). Additionally, connectivity between the ARAS and association networks predicted cognitive performance across several tasks over and above the effects of age and connectivity within the cortical networks themselves. These findings suggest that age differences in cortical connectivity may be driven, at least in part, by altered arousal signals from the brainstem and that ARAS-cortical connectivity relates to cognitive performance with age.

Looking the same, but remembering differently: Preserved eye-movement synchrony with age during movie watching.

Naturalistic stimuli (e.g., movies) provide the opportunity to study lifelike experiences in the lab. While young adults respond to these stimuli in a highly synchronized manner [as indexed by intersubject correlations (ISC) in their neural activity], older adults respond more idiosyncratically. Here, we examine whether eye-movement synchrony (eye-ISC) also declines with age during movie-watching and whether it relates to memory for the movie. Our results show no age-related decline in eye-ISC, suggesting that age differences in neural ISC are not caused by differences in viewing patterns. Both age groups recalled the same number of episodic details from the movie, but older adults recalled proportionally fewer episodic details due to their greater output of semantic and false information. In both age groups, higher eye-ISC related to a higher proportion of internal details and a lower proportion of false information being recalled. Finally, both older and younger adults showed better cued recall for cues taken from within the same event than those spanning an event boundary, further confirming that events are stored in long-term memory as discrete units with stronger associations within than across event boundaries. Taken together, these findings suggest that naturalistic stimuli drive perception in a similar way in younger and older adults, but age differences in neural synchrony further up the information processing stream may contribute to subtle differences in event memory. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

The ironic effect of older adults' increased task motivation: Implications for neurocognitive aging.

Recent work suggests that most older adults who volunteer to take part in cognitive experiments are more motivated to do well than are undergraduate students. This empirical evidence is echoed by the impressions of cognitive aging researchers. We surveyed a large group (N = 88) of researchers asking about their perceptions of younger and older adults' motivation to take part in lab-based research. Not only were older adults seen as more motivated than younger adults, but researchers thought that the two groups participate for different reasons: younger adults to obtain course credit or monetary compensation, older adults to get a sense of their cognitive health, to further science, and out of curiosity. However, older adults' greater motivation to do well on cognitive tasks may leave them vulnerable to stereotype threat, the phenomenon by which individuals underperform when they are put in a position to either confirm or deny a negative stereotype about their group. In this opinion piece, we argue that most cognitive experiments, not just those designed to measure stereotype threat, likely induce some form of performance-related anxiety in older adults. This anxiety likely leads to greater task-related interference, or thoughts about how one is doing on the task, resulting in poorer performance. We discuss some of the potential implications for our understanding of neurocognitive aging.

Implicit associative memory remains intact with age and extends to target-distractor pairs.

In this study, we use a novel, implicit memory paradigm to test forhyper-binding, or older adults' tendency to form non-target associations. Participants viewed pictures of objects superimposed with text and made speeded categorization judgments about the objects across three blocks varying in binding demand. During the no- and some-binding blocks, participants decided if the pictured object alone could fit inside a drawer while ignoring superimposed non-words and words, respectively. During the full-binding block, participants decided if both items could fit inside a drawer together. At test, participants viewed intact and rearranged pairs from encoding and decided if both items could fit in a drawer together. Across two experiments, older adults responded faster to intact than rearranged pairs from both the some- and full-binding blocks, while young adults showed no difference in RTs. These findings suggest that implicit associative memory is preserved with age and extends to non-target information.

Younger and older adults' prospective memory: the role of delay task difficulty.

There is mixed evidence on the impact of delay task difficulty on prospective memory (PM) performance and little research has examined this among older adults. The present study examined younger (N = 60) and older (N = 57) adults' prospective memory (PM) performance after completing an easy or difficult Raven's matrices task. To assess whether delay difficulty impacted how often participants thought about their PM intention, participants were asked to report on what they thought about during the delay task itself and retrospectively after all tasks were completed. Younger adults outperformed older adults on the PM task; however, delay task difficulty had no impact PM for either age group. Reports of thinking about the intention during the delay task differed by age group depending whether they were online or retrospective, however, overall greater reports of thinking about the intention was positively associated with PM performance.

Aging and inhibition: Introduction to the special issue.

Inhibitory theory suggests that a major determinant of individual differences in cognitive performance (including differences that are typically observed with increasing age) is the ability to dampen down goal-irrelevant stimuli, thoughts, and actions. While this theory has garnered a lot of support over the years, it has also seen several challenges. This special issue of Psychology and Aging entitled "Aging and Inhibition: The View Ahead" continues with this theme and includes 14 articles by top researchers in the field of cognitive aging. While most of the articles included here lend support to the theory, some challenge it or provide limiting conditions. We organize our overview of these articles according to the different functions, or stages, of inhibition, which we refer to as access, deletion, and restraint, followed by a discussion of potential moderators, including practice, motivation, and arousal. In our view, these articles contribute to our understanding of how and when age differences in inhibitory control are observed and the wider implications (both positive and negative) for cognition. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Reduced Attentional Control in Older Adults Leads to Deficits in Flexible Prioritization of Visual Working Memory.

Visual working memory (VWM) resources have been shown to be flexibly distributed according to item priority. This flexible allocation of resources may depend on attentional control, an executive function known to decline with age. In this study, we sought to determine how age differences in attentional control affect VWM performance when attention is flexibly allocated amongst targets of varying priority. Participants performed a delayed-recall task wherein item priority was varied. Error was modelled using a three-component mixture model to probe different aspects of performance (precision, guess-rate, and non-target errors). The flexible resource model offered a good fit to the data from both age groups, but older adults showed consistently lower precision and higher guess rates. Importantly, when demands on flexible resource allocation were highest, older adults showed more non-target errors, often swapping in the item that had a higher priority at encoding. Taken together, these results suggest that the ability to flexibly allocate attention in VWM is largely maintained with age, but older adults are less precise overall and sometimes swap in salient, but no longer relevant, items possibly due to their lessened ability to inhibit previously attended information.