Optimizing skin antisepsis for neonatal surgery: A quality improvement initiative.

PURPOSE: Surgical site infections (SSIs) are a significant determinant of morbidity in the Neonatal Intensive Care Unit (NICU). Chlorhexidine gluconate/isopropyl alcohol (CHG-IPA) skin prep has demonstrated superiority over Povidone-Iodine (PI) in preventing SSIs in adults, however FDA labeling discourages CHG use in infants <2 months. This project aimed to i) create evidence for safe CHG skin antisepsis in neonates; and ii) evaluate the safety and effectiveness of CHG skin prep for neonatal surgery. METHODS: A literature review was conducted to assess the safety and effectiveness of neonatal CHG skin antisepsis. Following stakeholder engagement, a CHG surgical skin prep protocol and validated neonatal skin integrity tool to assess prep-associated skin injury were implemented in 50 consecutive, eligible neonates ≥1500 g and ≥34 weeks post conceptual age undergoing abdominal or thoracic surgery. SSI rates were compared to a matched, historical PI skin prep cohort. RESULTS: 2%CHG-70%IPA or 0.5%CHG-70%IPA were used based on gestational age cutoffs. None of the CHG patients experienced adverse skin prep outcomes while 8% developed SSIs, compared to 14% in the historical PI cohort. CONCLUSION: This project engaged NICU stakeholders in quality improvement work and informed the implementation of a safe and effective CHG skin prep protocol for neonatal surgery. LOE: IV.

Case Reports: Management Challenges in Pediatric Germ Cell Tumors.

Germ cell tumors in infants are most frequently extragonadal, benign, and amenable to surgical resection. An unusual feature of germ cell tumors is the potential coexistence of malignant with benign disease which makes it possible for patients with incompletely resected tumors to experience either a benign or malignant recurrence. A challenge to postoperative surveillance is the interpretation of serum alpha fetoprotein, a marker of malignancy, that is physiologically elevated during the first year of life. A rare subset of germ cell tumors occur in the retroperitoneum. Although the vast majority are benign, these tumors are often large and distort normal anatomy, and may demonstrate local invasiveness that increases risk of resection. The intent of these reports is to caution readers about these unusual features of germ cell tumors of infancy.

Effects of age on listening and postural control during realistic multi-tasking conditions.

Successful performance of balance-related activities requires the effective integration of sensory, cognitive, and motor processes that can be affected by age-related changes. Of these age-related sensory changes, the effects of declines in hearing on balance have not been well-studied despite the fact that hearing loss has now been acknowledged as a significant risk factor for falls. The goal of this study was to evaluate age-related differences in a "standing while listening" task within increasingly challenging conditions resembling those that are often encountered in realistic, everyday situations. This study used a dual-task paradigm in an immersive Virtual Reality street scene setting in which postural load (firm, compliant), listening load (number of talkers), and visual load (eyes open/closed) were manipulated. A multi-talker divided attention listening task was used. Postural performance was assessed using center of pressure (COP) path length, while listening performance was assessed using spoken word recognition accuracy. Results demonstrated that age-related differences were observed in postural performance when postural demands were the highest and in listening performance when listening demands were the highest. Proportional dual-task costs were more pronounced for postural task performance compared to listening task performance and were more pronounced for older compared to younger adults. Postural dual-task costs increased as a function of increasing listening loads. Removal of visual information improved listening task performance across both groups and reduced the dual-task costs to listening in older adults when listening demands were highest (resulting in dual-task benefits). Taken together, the findings support previously documented age-related declines in postural control and auditory processing, demonstrate that increasing listening demands may result in poorer balance, particularly in older adults, and provide additional insights into the interactive effects of age-related declines when sensory, motor, and cognitive challenges are incremented factorially.

Multisensory, Multi-Tasking Performance of Older Adults With and Without Subjective Cognitive Decline.

As the population ages, it is increasingly important to detect non-normative cognitive declines as early as possible. Measures of combined sensory-motor-cognitive functioning may be early markers for identifying individuals who are at increased risk of developing dementia. Further, older adults experiencing subjective cognitive decline (SCD) may have elevated risk of dementia compared to those without SCD. Tasks involving complex, multisensory interactions reflective of everyday challenges may be particularly sensitive to subjectively perceived, pre-clinical declines. In the current study, older adults with and without SCD were asked to simultaneously perform a standing balance task and a listening task under increasingly challenging sensory/cognitive/motor conditions using a dual-task paradigm in a realistic, immersive virtual environment. It was hypothesized that, compared to older adults without SCD, those with SCD would exhibit greater decrements in postural control and listening response accuracy as sensory/motor/cognitive loads increased. However, counter to predictions, older adults with SCD demonstrated greater reductions in postural sway under more challenging dual-task conditions than those without SCD. Across both groups, poorer postural task performance was associated with poorer cognitive function and speech-in-noise thresholds measured with standard baseline tests. Poorer listening task performance was associated with poorer global cognitive function, poorer mobility, and poorer speech-in-noise detection. Overall, the results provide additional support for the growing evidence demonstrating associations between sensory, motor, and cognitive functioning and contribute to an evolving consideration of how best to categorize and characterize SCD in a way that guides strategies for screening, assessment, and intervention.