1.
Bioorg Med Chem Lett
; 18(7): 2362-7, 2008 Apr 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18346892
RESUMEN
A novel series of non-covalent, benzimidazole-based inhibitors of DPP-4 has been developed from a small fragment hit using structure-based drug design. A highly versatile synthetic route was created for the development of SAR, which led to the discovery of potent and selective inhibitors with excellent pharmaceutical properties.