In vivo tumor detection on rabbit with biopsy needle as MRE driver.

Magnetic Resonance Elastography (MRE) is a phase contrast imaging technique to quantitatively measure the elasticity of tissues. Typically, the oscillating driver is placed on the surface of objects to generate shear waves. When it is applied to detect tumors in deep location, the depth penetration of the wave is limited by attenuation and the biopsy procedure has to be performed separately. In this study, we describe a method using biopsy needle as the MRE driver to produce shear waves in tissues. We made comparison between the MRE acquisitions obtained with biopsy needle and surface drivers. Because the well-defined propagation wave pattern reduces the error in wavelength calculation, the acquisitions of biopsy needle driver shows better homogeneity in stiffness map. We also performed the experiment with the biopsy needle for in vivo tumor detection in rabbits. This study demonstrates that the biopsy needle driver is more effective than the surface driver for accurately measuring the stiffness and location of the tumor.

A study of femoral artery by twin drivers in magnetic resonance interference elastography.

Magnetic Resonance Elastography (MRE) is a phase-contrast technique using conventional Magnetic Resonance Imaging system to visualize propagating shear waves and study the stiffness of tissues. Usually, shear vibrations are applied to the surface of tissues by means of mechanical driver at one point. But in femoral artery study, the shear wave generated by the single driver on the surface of thigh cannot reach the femoral artery behind vein because of the blockage from the vein. In this study, the twin drivers set developed in our laboratory is used to overcome the problem. By using twin drivers driven simultaneously, interference shear wave pattern is generated. MR Interference Elastography is using interference shear wave image to study the stiffness of tissues. And, a finite element modeling was used to simulate single and twin driver datasets. The method was applied to in vivo human's femoral artery. And the result demonstrates the feasibility of this method. Further study will be conducted with the twin drivers in more in-vivo studies.

Biopsy needle as MRE driver for tumor detection.

Magnetic Resonance Elastography (MRE) is a phase contrast imaging technique to quantitatively measure the elasticity of tissues. Typically, an oscillating driver is placed on the surface to generate the shear waves. The depth penetration of the wave is limited by attenuation and the biopsy procedure has to be done separately. In this study, we use a biopsy needle as the driver to detect the 15% porcine gel inclusion in a 10% porcine gel phantom which simulates a tumor in tissues. We also perform the experiment with the biopsy needle for in-vivo tumor detection in rabbits. It is shown that the biopsy needle driver can accurately measure the stiffness and location of the tumor.

Magnetic resonance elastography with twin pneumatic drivers for wave compensation.

MR Elastography is a new technique using conventional MRI system to assess the elastic properties of tissues. When using pneumatic driver, usually one driver was put at one place of tissue. But the shear wave generated by one pneumatic driver cannot illuminate the large area due to the attenuation. So we use two pneumatic drivers driven synchronously to generate interference shear wave in our experiments. The results from the phantom study show the interference wave pattern generated by the twin pneumatic drivers can compensate the attenuation of the shear wave when propagating in phantom. Also, a finite element modeling was used to simulate twin pneumatic driver datasets. It is hoped that by twin pneumatic drivers, we can illuminate the whole brain; the liver and large areas in-vivo. Further study will be conducted with the twin pneumatic drivers in ex-vivo and in-vivo studies.

Needle shear wave driver for magnetic resonance elastography.

Magnetic resonance elastography (MRE) is capable of quantitatively depicting the mechanical properties of tissues in vivo. In contrast to mechanical excitation at the surface of the tissue, the method proposed in this study describes shear waves produced by an inserted needle. The results demonstrate that MRE performed with the needle driver provides shear stiffness estimates that correlate well with those obtained using mechanical testing. Comparisons between MRE acquisitions obtained with surface and needle drivers yielded similar results in general. However, the well-defined wave propagation pattern provided by the needle driver in a target region can reduce section orientation-related error in wavelength estimation that occurs with surface drivers in 2D MRE acquisitions. Preliminary testing of the device was performed on animals. This study demonstrates that the needle driver is an effective option that offers advantages over surface drivers for obtaining accurate stiffness estimates in targeted regions that are accessible by the needle.

Magnetic resonance elastography with twin drivers for high homogeneity and sensitivity.

Magnetic Resonance Elastography (MRE) is a phase-contrast technique using conventional Magnetic Resonance Imaging system to visualize propagating shear waves and study the stiffness of tissues. Usually, shear vibrations are applied to the surface of tissues by means of mechanical driver at one point. But it is hard for the single driver to detect very small tumors. Multiple drivers are expected to provide better elastogram and to be more sensitive to the small stiff inclusions. In this study, a pair of drivers was used and compared with the single driver. The result shows that using the twin drivers is more sensitive to small hard inclusions than using single driver. It is expected that the twin drivers can detect small tumors in tissues which can hardly be detected by a single driver. Further study will be conducted with the twin drivers in ex-vivo and in-vivo studies.

Shear waves induced by moving needle in MR elastography.

Magnetic resonance elastography (MRE) is a phase contrast-based method for observing shear wave propagation in a material to determine its stiffness. The objective of this study was to determine whether shear waves suitable for MRE could be induced using a moving acupuncture needle. Tissue-simulating bovine gel phantom and a 0.4 mm diameter acupuncture needle were used in the experiment. The results showed that observable shear waves could be induced in the gel phantom by cyclic needle motion. The observed wavelength varied with excitation frequency, as expected. Generating shear waves using moving needles may be a useful tool to study the basic mechanism of acupuncture with MRE. Further study will be conducted to observe the wave motion in inhomogeneous media and acupuncture-induced effects in in-vivo studies.