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1.
J Nat Prod ; 84(3): 553-561, 2021 03 26.
Artículo en Inglés | MEDLINE | ID: mdl-33684292

RESUMEN

Cinnamomum cassia Presl (Cinnamon) has been widely cultivated in the tropical or subtropical areas, such as Yunnan, Fujian, Guandong, and Hainan in China, as well as India, Vietnam, Thailand, and Malaysia. Four new glycosides bearing apiuronic acid (1, 4, 6, and 7) and their sodium or potassium salts (2, 3, and 5), together with 31 known compounds, were isolated from a hot water extract of the bark of C. cassia via repeated chromatography. The structures of the new compounds (1-7) were determined by NMR, IR, MS, and ICP-AES data and by acid hydrolysis and sugar analysis. This is the first report of the presence of apiuronic acid glycosides. Some of the isolates were evaluated for their analgesic effects on a neuropathic pain animal model induced by paclitaxel. Cinnzeylanol (8), cinnacaside (9), kelampayoside A (10), and syringaresinol (11) showed analgesic effects against paclitaxel-induced cold allodynia.


Asunto(s)
Analgésicos/farmacología , Glicósidos/farmacología , Neuralgia/tratamiento farmacológico , Analgésicos/aislamiento & purificación , Animales , Cinnamomum aromaticum/química , Glicósidos/aislamiento & purificación , Masculino , Ratones Endogámicos C57BL , Estructura Molecular , Fitoquímicos/aislamiento & purificación , Fitoquímicos/farmacología , Corteza de la Planta/química , República de Corea
2.
J Pharm Pharmacol ; 72(1): 149-160, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31713882

RESUMEN

OBJECTIVES: A botanical drug derived from the ethanolic extract composed of Clematis chinensis Osbeck (Ranunculaceae), Trichosanthes kirilowii Maximowicz (Cucurbitaceae) and Prunella vulgaris Linné (Lamiaceae) has been used to ameliorate rheumatoid arthritis as an ethical drug in Korea. In our study, we investigated the effect of this herbal complex extract (HCE) on schizophrenia-like behaviours induced by MK-801. METHODS: HCE (30, 100 or 300 mg/kg, p.o) was orally administered to male ICR mice to a schizophrenia-like animal model induced by MK-801. We conducted an acoustic startle response task, an open-field task, a novel object recognition task and a social novelty preference task. KEY FINDINGS: We found that a single administration of HCE (100 or 300 mg/kg) ameliorated MK-801-induced abnormal behaviours including sensorimotor gating deficits and social or object recognition memory deficits. In addition, MK-801-induced increases in phosphorylated Akt and GSK-3ß expression levels in the prefrontal cortex were reversed by HCE (30, 100 or 300 mg/kg). CONCLUSIONS: These results imply that HCE ameliorates MK-801-induced dysfunctions in prepulse inhibition, social interactions and cognitive function, partly by regulating the Akt and GSK-3ß signalling pathways.


Asunto(s)
Antipsicóticos/farmacología , Conducta Animal/efectos de los fármacos , Cognición/efectos de los fármacos , Disfunción Cognitiva/prevención & control , Trastornos Neurológicos de la Marcha/prevención & control , Extractos Vegetales/farmacología , Corteza Prefrontal/efectos de los fármacos , Esquizofrenia/prevención & control , Filtrado Sensorial/efectos de los fármacos , Animales , Clematis , Disfunción Cognitiva/inducido químicamente , Disfunción Cognitiva/fisiopatología , Disfunción Cognitiva/psicología , Modelos Animales de Enfermedad , Maleato de Dizocilpina , Trastornos Neurológicos de la Marcha/inducido químicamente , Trastornos Neurológicos de la Marcha/fisiopatología , Trastornos Neurológicos de la Marcha/psicología , Glucógeno Sintasa Quinasa 3 beta/metabolismo , Locomoción/efectos de los fármacos , Masculino , Ratones Endogámicos ICR , Fosforilación , Corteza Prefrontal/metabolismo , Corteza Prefrontal/fisiopatología , Proteínas Proto-Oncogénicas c-akt/metabolismo , Prunella , Reconocimiento en Psicología/efectos de los fármacos , Reflejo de Sobresalto/efectos de los fármacos , Esquizofrenia/inducido químicamente , Psicología del Esquizofrénico , Conducta Social , Trichosanthes
3.
J Agric Food Chem ; 67(26): 7289-7296, 2019 Jul 03.
Artículo en Inglés | MEDLINE | ID: mdl-31244195

RESUMEN

The flower buds of Rosa rugosa Thunb. have been commonly used as a source of rose oil and as an ingredient in tea in eastern Asia, including China, Japan, and Korea. Repeated chromatography of a hot water extract from the flower buds of R. rugosa led to the isolation and characterization of three new depside glucosides, rosarugosides A-C (1-3), along with three phenolic compounds, one ionone glucoside, four flavonoids, and two tannins having known chemical structures. Linarionoside A and 2-phenylethyl-(6- O-galloyl)-ß-d-glucopyranoside were isolated from R. rugosa for the first time in this study. The structures of the new compounds 1-3 were elucidated by interpreting one- and two-dimensional nuclear magnetic resonance spectroscopic and mass spectrometric data. Among the isolates, a new depside glucoside (1) and two major phenolic glucosides (4 and 5) improved MK-801-induced sensorimotor gating deficits, which were measured via an acoustic startle response test in mice.


Asunto(s)
Fármacos del Sistema Nervioso Central/química , Depsidos/química , Flores/química , Glucósidos/química , Extractos Vegetales/química , Rosa/química , Animales , Fármacos del Sistema Nervioso Central/aislamiento & purificación , Fármacos del Sistema Nervioso Central/farmacología , Depsidos/aislamiento & purificación , Depsidos/farmacología , Glucósidos/aislamiento & purificación , Glucósidos/farmacología , Masculino , Ratones , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/farmacología , Filtrado Sensorial/efectos de los fármacos
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