RESUMEN
Recent studies in Western cultures suggested emotion regulation goals have important implications for mental health. This study aimed to test the factor structure of Emotion Regulation Goals Scale (ERGS) in a Chinese cultural context. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were first used to examine the factor structure of the ERGS, and then reliability and validity tests were conducted to examine the psychometric properties of the ERGS. Results showed that the original five-factor model demonstrated fit during both EFA and CFA, and was thus adopted for further psychometric analyses. Most of the five factors were significantly associated with emotion regulation tendencies and negative emotional outcomes (e.g., depression), except for the non-significant associations between pro-hedonic goals and expressive suppression, and pro-social and impression management goals with depression. The ERGS also showed good internal consistency and split-half reliability. However, the test-retest reliabilities varied substantially across the five factors. The pro-hedonic goal had a higher test-retest reliability, whereas the contra-hedonic, performance, pro-social, and impression management goals showed lower values, especially the latter two. In brief, the ERGS showed a promising five-factor structure in assessing emotion regulation goals in Chinese cultural context.
RESUMEN
Objective: Schizophrenia patients often have personality disorders; schizophrenia patients with personality disorders are more difficult to treat and have a worse prognosis. Early identification of this group of patients and early intervention can achieve better prognosis. Therefore, it is very important to explore effective biomarkers and early diagnosis for the prognosis of schizophrenia. The primary purpose of this paper is to explore the relationship between plasma miRNA expression level and personality disorder with schizophrenia. Methods: Gene microarrays in miRNA files were employed, and the plasma of peripheral blood of 82 schizophrenic patients and 43 healthy control subjects were examined. Real-time reverse transcription polymerase chain reaction detection were performed to explore the results. Spearman correlation analysis was used to analyze the correlation between expression level of miRNAs and Personality Diagnosis Questionnaire-4 score. Results: The results showed that miR-1273d, miR-1303, miR-3064-5p, miR-3131, miR-3687, miR-4428, miR-4725-3p, and miR-5096 were up-regulated in schizophrenic patients. Compared to healthy control subjects, the difference was statistically significant (P < .05). Schizophrenic patients with schizoid, paranoid, schizotypal, and obsessive compulsive traits had negative correlation with miR-1303, miR-3131, miR-4428, and miR-5096 expression level (r = -0.40 to -0.62, P < .05); there were no significant differences in the other miRNAs. Correlation with other personality traits was not significant (P > .05). The stepwise regression analysis indicated that miR-5096, miR-3131, and miR-1273d have a significant predictive effect on the schizoid trait (P < .01). MiR-4428 and miR-1303 had a significant predictive effect on the schizotypal trait (P < .01). MiR-5096, miR-4428, and miR-4725-3P had a significant predictive effect on the paranoid trait (P < .05). MiR-4428, miR-1303, and miR-5096 had a significant predictive effect on the obsessive compulsive trait (P < .05). Conclusion: The expression levels of miR-1273d, miR-1303, miR-3064-5p, miR-3131, miR-3687, miR-4428, miR-4725-3p, and miR-5096 were up-regulated in the peripheral blood of patients with schizophrenia, and these miRNAs are expected to be diagnostic biomarkers for accurate diagnosis of schizophrenia. The expression levels of miR-1303, miR-3131, miR-1273d, miR-4428, miR-4725-3p, and miR-5096 have significant predictive effects on personality disorder in schizophrenia.
RESUMEN
Pumpkin polysaccharide (PPe-H) can perform physiological functions through its antioxidative and hypoglycemic effects; however, the mechanisms through which PPe-H regulates abnormal glucose and lipid metabolism caused by oxidative stress injury remain unclear. In the present study, streptozotocin was used to generate an acute diabetic mouse model, and the effects of PPe-H on glucose and lipid metabolism impaired by oxidative stress in diabetic mice were studied. PPe-H significantly reduced blood glucose levels and enhanced the oral glucose tolerance of diabetic mice under stress injury (pâ¯<â¯0.05). The analysis of liver antioxidant enzymes showed that PPe-H significantly enhanced the activities of SOD and CAT (pâ¯<â¯0.05), increased the GSH level, and decreased the level of MDA (pâ¯<â¯0.05). Transcriptomic and metabolomic analyses of the liver tissues of mice revealed characteristic differences in the genetic and metabolic levels of the samples, which showed that PPe-H treatment may play a positive role in regulating the metabolism of methionine, cysteine, glycerol phospholipid, and linoleic acid. These results indicated that PPe-H alleviated the symptoms of hyperglycemia by regulating metabolites related to oxidative stress and glycolipid metabolism in diabetic mice.
Asunto(s)
Cucurbita , Diabetes Mellitus Experimental , Metabolismo de los Lípidos , Estrés Oxidativo , Polisacáridos , Animales , Estrés Oxidativo/efectos de los fármacos , Polisacáridos/farmacología , Diabetes Mellitus Experimental/tratamiento farmacológico , Diabetes Mellitus Experimental/metabolismo , Ratones , Metabolismo de los Lípidos/efectos de los fármacos , Masculino , Cucurbita/química , Glucemia/metabolismo , Hígado/metabolismo , Hígado/efectos de los fármacos , Antioxidantes/farmacología , Glucosa/metabolismo , MetabolómicaRESUMEN
Introduction: First episode and drug naive schizophrenia (SZ) patients comorbid with major depressive episode and generalized anxiety disorder (GAD) comorbid with major depressive disorder (MDD) are common in clinical practice, overlapping symptomatology during first presentation of MDD, SZ and GAD challenged the diagnostic process. Materials and Methods: This study aimed to investigate the differentiation value of peripheral microRNA-26b expression in 52 patients of MDD, SZ, and GAD, respectively, and 52 controls. Quantitative real-time reverse transcription polymerase chain reaction was used to further verify aberrant miRNAs of previous identified in MDD and investigate expression level of these peripheral miRNAs in SZ and GAD. Results: The expression levels of miR-26b and miR-4743 were significantly upregulated and of miR-4498, miR-4485, and miR-1972 had no significant difference. There were no significant differences of expression levels of miR-26b, miR-4498, miR-4485, and miR-1972 except miR-4743 between SZ patients and control group and of miR-26b, miR-1972, miR-4498, and miR-4485 between GAD group and the controls. The receiver operating characteristic (ROC) curve of miR-26b in MDD patients showed that its sensitivity and specificity for diagnosis were 0.540 and 0.830, respectively, with the area under curve (AUC) being 0.728; the ROC of miR-26b for SZ and MDD differentiation showed that its sensitivity and specificity were 0.580 and 0.710, respectively, with AUC being 0.631; the ROC of miR-26b for GAD and MDD differentiation suggested that sensitivity and specificity were 0.560 and 0.750, respectively, with AUC being 0.637. Conclusion: MiR-26b might have potential value of differentiation biomarker for MDD, SZ, and GAD.
RESUMEN
Negative self-schema is a core symptom of depression. According to social psychological theories, two types of self-evaluations play important roles in forming the negative self-view: direct self-evaluation (that is, evaluating the self directly through one's first-person perspective introspection) and reflected self-evaluation (which requires theory of mind (ToM) ability, and is evaluating the self through reflecting on a third person's perspective). Although many previous studies have investigated the processing of the direct self-evaluation in depression, few have extended research on the reflected self-evaluation. In the current study, functional magnetic resonance imaging scans were acquired in 26 dysphoric (individuals with elevated number of depressive symptoms) and 28 control participants during both direct and reflected self-evaluation tasks. Two regions of interest were defined within bilateral temporoparietal junctions (TPJs) because their significant role in ToM. Results showed that the dysphoric participants evaluated themselves more negatively than the control participants, regardless of whose perspective they were taking. More importantly, the enhanced TPJs' activations were observed in the control group during the reflected self-evaluation task versus the direct self-evaluation task, whereas no such difference was observed in the dysphoric participants. The results are interpreted in the framework of impaired ToM ability in sub-clinical depression. General Scientific Summary (GSS) Negative self-schema is one of the core symptoms of depression. This study suggests that the negative self-schema reflects not only in direct self-evaluation (i.e. evaluating the self via one's own introspection) but also in reflected self-evaluation (i.e. evaluating the self via others' perspective). Importantly, altered TPJ activity was found during a reflected self-evaluation task among individuals with depressive symptoms. These changes in brain function might be associated with impaired ToM ability in sub-clinical depression.
Asunto(s)
Trastorno Depresivo Mayor , Teoría de la Mente , Humanos , Autoevaluación Diagnóstica , Depresión/diagnóstico por imagen , Autoimagen , Imagen por Resonancia MagnéticaRESUMEN
As a major contributor to the development of depression, rumination has proven linked with aberrant default-mode network (DMN) activity. However, it remains unclear how the spontaneous spatial and temporal activity of DMN underlie the association between rumination and depression. To illustrate this issue, behavioral measures and resting-state functional magnetic resonance images were connected in 2 independent samples (NSample1 = 100, NSample2 = 95). Fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) were used to assess spatial characteristic patterns, while voxel-wise functional concordance (across time windows) (VC) and Hurst exponent (HE) were used to assess temporal dynamic patterns of brain activity. Results from both samples consistently show that temporal dynamics but not spatial patterns of DMN are associated with rumination. Specifically, rumination is positively correlated with HE and VC (but not fALFF and ReHo) values, reflecting more consistent and regular temporal dynamic patterns in DMN. Moreover, subregion analyses indicate that temporal dynamics of the ventromedial prefrontal cortex (VMPFC) reliably predict rumination scores. Furthermore, mediation analyses show that HE and VC of VMPFC mediate the association between rumination and depression. These findings shed light on neural mechanisms of individual differences in rumination and corresponding risk for depression.
Asunto(s)
Depresión , Corteza Prefrontal , Depresión/diagnóstico por imagen , Corteza Prefrontal/diagnóstico por imagen , Imagen por Resonancia Magnética/métodos , Individualidad , Lenguaje , Mapeo Encefálico/métodos , EncéfaloRESUMEN
Motivation is considered important in the study of emotion regulation. However, it remains unknown whether and how varied motivation may influence people's emotion regulation choice. To address this question, 51 participants first performed a global-local task that measures attentional breadth. Then, they were required to choose emotion regulation strategies, reappraisal, or distraction, to regulate their emotion in emotional contexts that varied in motivational direction and intensity. We found that distraction was chosen more often over reappraisal in high-intensity-motivated emotion, while the reverse pattern was observed in low-intensity motivated emotion. Besides, withdrawal-motivated emotion was associated with more reappraisal choices than approach-motivated emotion, an effect that, however, vanished when valence was controlled. Furthermore, participants made fewer global choices, which is indicative of narrowed attentional breadth, during high- relative to low-intensity motivated emotional contexts, and attentional breadth partially mediated the effect of motivational intensity on emotion regulation choice. These findings suggest that increased motivation promotes one's choice of distraction over reappraisal during emotion regulation, by narrowing attentional breadth. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Asunto(s)
Regulación Emocional , Atención/fisiología , Emociones/fisiología , Humanos , MotivaciónRESUMEN
Emotional regulation is known to be associated with activity in the amygdala. The amygdala is an emotion-generative region that comprises of structurally and functionally distinct nuclei. However, little is known about the contributions of different frontal-amygdala sub-region pathways to emotion regulation. Here, we investigated how functional couplings between frontal regions and amygdala sub-regions are involved in different spontaneous emotion regulation processes by using an individual-difference approach and a generalized psycho-physiological interaction (gPPI) approach. Specifically, 50 healthy participants reported their dispositional use of spontaneous cognitive reappraisal and expressive suppression in daily life and their actual use of these two strategies during the performance of an emotional-picture watching task. Results showed that functional coupling between the orbitofrontal cortex (OFC) and the basolateral amygdala (BLA) was associated with higher scores of both dispositional and actual uses of reappraisal. Similarly, functional coupling between the dorsolateral prefrontal cortex (dlPFC) and the centromedial amygdala (CMA) was associated with higher scores of both dispositional and actual uses of suppression. Mediation analyses indicated that functional coupling of the right OFC-BLA partially mediated the association between reappraisal and emotional response, irrespective of whether reappraisal was measured by dispositional use (indirect effect(SE)=-0.2021 (0.0811), 95%CI(BC)= [-0.3851, -0.0655]) or actual use (indirect effect(SE)=-0.1951 (0.0796), 95%CI(BC)= [-0.3654, -0.0518])). These findings suggest that spontaneous reappraisal and suppression involve distinct frontal- amygdala functional couplings, and the modulation of BLA activity from OFC may be necessary for changing emotional response during spontaneous reappraisal.
Asunto(s)
Complejo Nuclear Basolateral/fisiología , Emociones/fisiología , Imagen por Resonancia Magnética/métodos , Red Nerviosa/fisiología , Corteza Prefrontal/fisiología , Adolescente , Adulto , Complejo Nuclear Basolateral/diagnóstico por imagen , Femenino , Humanos , Masculino , Red Nerviosa/diagnóstico por imagen , Estimulación Luminosa/métodos , Corteza Prefrontal/diagnóstico por imagen , Autoinforme , Adulto JovenRESUMEN
Automatic emotion regulation (AER) plays a vital role in the neuropathology underlying both suicide and self-harm via modifying emotional impact effortlessly. However, both the effortless account and the neural mechanisms of AER are undetermined. To investigate the neural changes at AER, we collected functional MRI (fMRI) in 31 participants who attended to neutral and disgust pictures in three conditions: watching, goal intention (GI), and reappraisal by implementation intention (RII). Results showed that RII (but not GI) decreased negative feelings and bilateral amygdala activity without increasing cognitive efforts, evidenced by the reduced effort rating and less prefrontal engagement during RII compared with during watching and GI. These emotion-regulatory effects of RII cannot be explained by emotional habituation, as the supplementary experiment (N = 31) showed no emotional habituation effects when the same disgust pictures were presented repeatedly three times for each watching and GI condition. Task-based network analysis showed both RII and GI relative to watching increased functional connectivities (FCs) of the ventral anterior cingulate cortex to the left insula and right precuneus during conditions, two FCs subserving goal setup. However, RII relative to GI exhibited weaker FCs in brain networks subserving effortful control, memory retrieval, aversive anticipation, and motor planning. In these FCs, the FC intensity of putamen-operculum/lingual and paracentral-superior temporal gyri positively predicted regulatory difficulty ratings. These findings suggest that the setup of implementation intention automatizes emotion regulation by reducing the online mobilization of emotion-coping neural systems.
Asunto(s)
Encéfalo/fisiología , Regulación Emocional/fisiología , Intención , Imagen por Resonancia Magnética/métodos , Red Nerviosa/fisiología , Encéfalo/diagnóstico por imagen , Femenino , Humanos , Masculino , Red Nerviosa/diagnóstico por imagen , Estimulación Luminosa/métodos , Desempeño Psicomotor/fisiología , Adulto JovenRESUMEN
Implementation intentions (II), which specify how to respond in a given situation based on the goal, is known for its automaticity of regulating emotion to the specified situation. However, it is unknown whether such regulatory effects can be generalized to unspecified situations. For this purpose, we performed four experiments, each consisting of specified (bloody) and unspecified (non-bloody) stimuli with the goal of disgust (Exp.1-2) or unpleasant (Exp.3) regulation. Results showed that II reduced negative feelings for both bloody and non-bloody situations (Exp.1). This generalization effect was absent for goal-unrelated, frightening situations (Exp.2). However, broadening the goal extended the generalization effect to the frightening situation, an effect further amplified when a flexible response was used (Exp.3). Moreover, the II buildup did not disrupt feelings for pleasant situations (Exp.4). These results provide the first evidence that II-based emotion regulation is generalizable to unspecified, goal-related situations and that increasing goal coverage expands the generalization.
Asunto(s)
Regulación Emocional , Objetivos , Intención , Emociones , Humanos , MotivaciónRESUMEN
Implementation intention has proven effective in regulating intense emotions but is found to be difficult when instructed regulation is used. Here, we aim to test whether automatic reappraisal-based implementation intention (RII) downregulates intense negative emotion more efficiently than controlled reappraisal (CR) using a two-phase event-related potential (ERP) experiment. In the regulation phase, both RII and CR decreased subjective experiences of negative emotion relative to passive watching, irrespective of emotional intensity. Moreover, RII reduced the central-parietal late positive potential (LPP) amplitudes for both intensities in the 300-1,700-ms epoch after picture onset, whereas CR reduced LPP amplitudes just in the 500-700-ms interval. Moreover, the application of RII but not CR produced a reliable long-term LPP attenuation compared to passive watching in the unexpected re-exposure phase. These findings demonstrate that reappraisal-based implementation intention yields an earlier and more sustainable emotion regulatory effects than controlled reappraisal.
RESUMEN
Instructed fear, which denotes fearful emotions learned from others' verbal instructions, is an important form of fear acquisition in humans. Maladaptive instructed fear produces detrimental effects on health, but little is known about performing an efficient regulation of instructed fear and its underlying neural substrates. To address this question, 26 subjects performed an instructed fear task where emotional experiences and functional neuroimages were recorded during watching, explicit regulation (calmness imagination), and implicit regulation (calmness priming) conditions. Results indicated that implicit regulation decreased activity in the left amygdala and left insula for instructed fear; however, these effects were absent in explicit regulation. The implementation of implicit regulation did not increase activity in the frontoparietal control regions, while explicit regulation increased dorsolateral prefrontal cortex activity. Furthermore, implicit regulation increased functional connectivity between the right amygdala and right fusiform gyrus, and decreased functional connectivity between the right medial temporal gyrus and left inferior frontal gyrus, which are key nodes of memory retrieval and cognitive control networks, respectively. These findings suggest a favourable effect of implicit regulation on instructed fear, which is subserved by less involvement of control-related brain mechanisms.
RESUMEN
Anammox process was regarded to be one of the vital links to achieve energy-saving or energy-producing wastewater treatment plant. In the study, an anammox reactor with the nitrogen gas circulation was constructed to culture anammox granules, and the performance, granule size distribution, and microbial community were investigated. Dissolved oxygen loading is found to be an important factor for the start-up of the anammox process, and the nitrogen removal rate of 2.12 kg N m-3 day-1 was achieved under the average nitrogen loading rate of 2.6 kg N m-3 day-1. The activity test showed that the highest specific anammox activity of 345.9 mg N gVSS-1 day-1 was achieved for granules with size of 0.5-1.0 mm. The Illumina high-throughput sequencing analysis revealed the consistent variation of Candidatus Brocadia and Denitratisoma abundance in granues of all sizes, suggesting possible synergistic mechanism between heterotrophic bacteria Denitratisoma and anammox bacteria Ca. Brocadia. Furthermore, the results indicated the reactor with the nitrogen gas circulation is an efficient strategy to start-up anammox.
Asunto(s)
Reactores Biológicos , Microbiota , Anaerobiosis , Nitrógeno , Oxidación-Reducción , Aguas del AlcantarilladoRESUMEN
The role of gender role in interpreting sex differences in emotion is unknown. The present study examined how gender role moderates sex differences in emotional reactivity. Event-related potentials (ERP) were recorded in sixty-eight subjects with typical or androgynous gender roles when they passively observed neutral and negative pictures. Behaviorally, typical females (feminine females) reported higher emotional rating than typical males (masculine males), while androgynous males and androgynous females reported no significant differences. Electrophysiologically, we found higher late positive potential (LPP) amplitude in typical females compared to typical males, while this pattern of sex difference was absent in androgynous subjects. The network analysis of EEG data indicates that typical males showed enhanced network coupling strengths between frontal/prefrontal and parietal areas than typical females, which was again absent in androgynous subjects. These findings suggest that gender role is an important determinant in the interpretation of sex differences in emotional reactivity.
Asunto(s)
Encéfalo/fisiología , Emociones/fisiología , Identidad de Género , Caracteres Sexuales , Adulto , Electroencefalografía , Potenciales Evocados , Femenino , Humanos , Masculino , Vías Nerviosas/fisiología , Adulto JovenRESUMEN
Based on their differences in the kinetic values, the nitrifiers could be classified into the fast-growing "r-strategists" and the slow-growing "K-strategists" bacteria. However, the difference in the kinetic values originated not only from the intrinsic differences among the nitrifier species, but also from other factors, i.e. sludge floc morphology, and the environment in which the nitrifiers were cultivated. It is not clear how these factors interact and affect the measured kinetic parameters and the competition among the "r-strategists" and the "K-strategists" bacteria. In this study, the kinetic parameters of nitrifiers cultivated in the SBR (sequencing batch reactor) under different substrate concentrations were monitored, together with the identification of nitrifier species and sludge floc morphology characterization. The results showed that the r-AOB and r-NOB ("r-strategists" ammonium-oxidizing bacteria and nitrite-oxidizing bacteria, i.e., Nitrosomonas and Nitrospira) were the dominant nitrifiers in the SBR reactor. A mathematical model describing the competition between r/K AOB and NOB showed that r-AOB and r-NOB could be enriched in the SBR. The experimental investigation supported the model simulation results. The model simulation also revealed that the different r/K AOB and NOB species could be enriched in different DO concentrations and SRT conditions, which could be manipulated to promote the growth of r-AOB and NO2- accumulation for the autotrophic nitrogen removal using ANAMMX.
Asunto(s)
Modelos Teóricos , Nitrificación , Eliminación de Residuos Líquidos , Amoníaco , Compuestos de Amonio/metabolismo , Procesos Autotróficos , Bacterias/metabolismo , Cinética , Nitritos , Nitrógeno , Oxidación-Reducción , Aguas del AlcantarilladoRESUMEN
Detachment (self-focused) and positive reinterpretation (situation-focused) are two important forms of cognitive reappraisal during emotion regulation. Previous research shows situation-focused reappraisal to be more effective than self-focused reappraisal for intentional emotion regulation. How the two differ in emotional consequences as components of automatic emotion regulation is however unclear. In the current study, event-related potentials were recorded to clarify this problem, while participants passively viewed disgusting or neutral scenes or formed implementation intentions based on self-focused or situation-focused reappraisal. Behavioural results showed fewer negative emotions during self-focused reappraisal than during either situation-focused reappraisal or free viewing (which had similar emotion ratings). In addition, self-reported cognitive cost was not enhanced during the two forms of reappraisal compared to passive viewing. Late positive potential (LPP) amplitudes for disgusting stimuli were larger than those elicited for neutral stimuli, at both frontal and posterior-parietal regions. This amplitude enhancement effect, irrespective of whether frontal or parietal LPP were involved, was found to be weaker during self-focused reappraisal than when participants were engaged in situation-focused reappraisal or passive viewing. The latter two conditions showed similar amplitude enhancement. These findings suggest that automatic self-focused reappraisal by implementation intention produces more favourable emotion regulation than situation-focused reappraisal, without enhancing cognitive cost.
RESUMEN
BACKGROUND We previously discovered that 3 long non-coding RNAs (lncRNAs) NONHSAT089447, NONHSAT021545, and NONHSAT041499 were differentially expressed in the peripheral blood of patients with schizophrenia, in comparison to those in normal healthy controls. In this study, we conducted bioinformatic analysis of these 3 lncRNAs and the regulatory role of lncRNA NONHSAT089447 in the dopamine signaling pathway in patients with schizophrenia. MATERIAL AND METHODS There lncRNAs in peripheral blood mononuclear cells (PBMCs) were screened using microarray analysis. Pearson's correlation analysis was performed to assess the levels of co-expressed mRNAs of respective lncRNAs. The Database for Annotation, Visualization and Integrated Discovery (DAVID) software was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes or Genomes (KEGG) enrichment analysis for these lncRNAs. Human neuroblastoma cell lines (SK-N-SH) were cultured and treated with dopamine or olanzapine (OLP), or transfected with siRNA targeting NONHSAT089447 or plasmid expressing NONHSAT089447. Levels of lncRNAs were detected by quantitative real-time reverse transcription polymerase chain reaction (RT-PCR). Then, mRNA and protein expression of the dopamine receptors DRD1, DRD2, DRD3, DRD4, and DRD5 were measured by RT-PCR and western blot analysis, respectively. RESULTS OLP treatment significantly inhibited the expression of NONHSAT089447. Knockdown of NONHSAT089447 by siRNA decreased DRD3 and DRD5 expression, while overexpression of NONHSAT089447 significantly upregulated expression of DRD3 and DRD5. Western blot analysis confirmed that levels of NONHSAT089447 regulated downstream DRD signaling. CONCLUSIONS Our results revealed that the lncRNA NONHSAT089447 participated in the dopamine signaling pathway via upregulation of DRDs.
Asunto(s)
Dopamina/metabolismo , ARN Largo no Codificante/metabolismo , Esquizofrenia/metabolismo , Adulto , Trastornos de Ansiedad/metabolismo , Línea Celular Tumoral , Biología Computacional/métodos , Trastorno Depresivo Mayor/metabolismo , Dopamina/genética , Perfilación de la Expresión Génica , Ontología de Genes , Humanos , Análisis de Secuencia por Matrices de Oligonucleótidos/métodos , ARN Largo no Codificante/genética , ARN Mensajero/genética , Reacción en Cadena en Tiempo Real de la Polimerasa , Esquizofrenia/genética , Transducción de Señal/genéticaRESUMEN
The acceptance of emotion is important for humans' wellbeing and social functioning. Despite its regulatory advantages, the temporal dynamics of acceptance for regulating decision-related emotion remains unclear. For this purpose, Event-related potentials were recorded for outcome presentation, when participants either in explicit or implicit acceptance condition performed a Gambling Task. Results showed that acceptance effectively regulated emotional experiences, irrespective of how it was realized (explicit/implicit). Compared to viewing condition, explicit acceptance increased overall amplitudes of feedback-related negativity (FRN,180-240â¯ms) at the early stage and reduced P3 amplitude (240-440â¯ms) in general at the late stage, regardless of feedback valence or magnitude. By contrast, implicit acceptance did not influence the FRN amplitudes but increased the P3 amplitudes globally, an effect unaffected by feedback valence and magnitude. In addition, the P3 amplitude for explicit acceptance was negatively correlated with the ratio of risky choices, regardless of outcome valence. These results suggest that explicit acceptance is associated with cognitive conflict and resource depletion, while these adverse effects are not engendered during implicit acceptance. These regulatory effects are independent of specific feedback valence and magnitude. These findings highlight the role of implicit acceptance in cognitive demanding context, such as decision-making.
Asunto(s)
Conducta/fisiología , Toma de Decisiones/fisiología , Emociones/fisiología , Potenciales Relacionados con Evento P300/fisiología , Juego de Azar/psicología , Estimulación Luminosa/métodos , Femenino , Humanos , Masculino , Distribución Aleatoria , Adulto JovenRESUMEN
Aim: To assess whether expression of circular RNAs (circRNAs) in peripheral blood mononuclear cells can serve as a biomarker for diagnosis and/or therapeutic response in people living with schizophrenia (SZ). Materials & methods: Differentially expressed circRNAs were screened via microarray in nine individuals living with SZ and nine healthy controls, then quantified using real-time quantitative reverse transcription PCR in SZ (n = 102) and healthy control (n = 103) groups. CircRNAs were re-assessed twice in 30 randomly selected individuals living with SZ after 4- and 8-week antipsychotic treatments. Results: Five circRNAs were differentially expressed between groups. Only hsa_circRNA_104597, which was downregulated in the SZ group, was significantly upregulated after 8-week treatment. Conclusion: Dysregulation of hsa_circRNA_104597 may serve as a novel potential diagnostic and therapeutic biomarker for SZ.
Asunto(s)
ARN Circular/genética , Esquizofrenia/diagnóstico , Esquizofrenia/terapia , Adolescente , Adulto , Anciano , Biomarcadores/metabolismo , Femenino , Regulación de la Expresión Génica , Humanos , Masculino , Persona de Mediana Edad , Olanzapina/uso terapéutico , Esquizofrenia/tratamiento farmacológico , Esquizofrenia/genética , Adulto JovenRESUMEN
Cognitive reappraisal is associated with major depressive disorder (MDD), while spontaneous activity patterns of the default mode network (DMN) is implicated in reappraisal and MDD. However, neural mechanisms subserving the close association of spontaneous reappraisal and depression are unclear. Spontaneous reappraisal, depression and resting-state functional magnetic resonance imaging (rsfMRI) were measured from 105 healthy subjects. We assessed the temporal complexity (Hurst exponent), Regional Homogeneity (ReHo) and fractional Amplitude of Low Frequency Fluctuation (fALFF) profiles of DMN, a network involved in both reappraisal and depression. Mediation effects of these standard measures on the relationship between reappraisal and depression, and the contributions of each DMN subregion, were assessed. Results indicated that Hurst exponent (H) of DMN, whether extracted by independent component analysis (ICA) or region of interest (ROI), was significantly associated with reappraisal scores. An individual with a higher reappraisal score has a lower Hurst value of DMN. Mediation analyses suggest that H of DMN partially mediates the association between reappraisal and the degree of depression, and this mediation effect arises from the contribution of medial prefrontal cortex. Neither ReHo nor fALFF showed a similar correlation or mediation effect. These findings suggest that temporal dynamics of DMN play an important role in emotion regulation and its association with depression. H of DMN may serve as a neural marker mediating the association between reappraisal and depression.