Behçet's syndrome masquerading as infective endocarditis: A diagnostic conundrum and therapeutic challenge.

This case report presents a 20-year-old male patient initially diagnosed with infective endocarditis, later correctly identified as Behçet's syndrome. The patient's complex clinical presentation, including chest pain, aortic dilation, severe aortic regurgitation, and aortic root abscess, posed significant diagnostic and therapeutic challenges. Despite initial misdiagnosis and treatment difficulties, the patient's condition significantly improved with appropriate immunosuppressive therapy, underscoring the potential for successful management of this complex condition. This case serves as a valuable reminder of the diagnostic challenges posed by Behçet's syndrome and the importance of considering this condition in patients presenting with symptoms suggestive of infective endocarditis.

Clinical and pathological spectrum of aortitis in a Chinese cohort.

BACKGROUND: This study aimed to explore the clinical and pathological features of aortitis in China, which is a rare disease that is often overlooked preoperatively. METHODS: We reviewed the records of 2950 patients who underwent aortic surgery at Wuhan Asia General Hospital from 2016 to 2023. Clinical and pathological data were collected and compared across different groups. RESULTS: Out of 2950 patients, 15 had healed aortitis, 2 were healed Takayasu aortitis (TAK), and 13 were not further classified. Forty-two had active aortitis, including clinically isolated aortitis ([CIA], 42.9%), infectious aortitis ([IA], 26.2%), TAK (16.7%), and Behçet's syndrome ([BS], 14.3%), half of these cases were not recognized preoperatively. All patients who developed perivalvular leakage during follow-up had concurrent non-infectious valvulitis with mixed inflammatory pattern at the time of initial surgery. Seventeen out of 18 patients with CIA survived without complications, as did 8 out of 11 patients with IA, 6 out of 7 patients with TAK, and 2 out of 6 patients with BS. CONCLUSIONS: Half of the aortitis cases were initially diagnosed by pathologists. Noninfectious valvulitis with mixed inflammatory pattern is a risk factor for perivalvular leakage. BS is associated with a higher rate of complications. Patients with CIA have a good prognosis in China, which is different from the West.

The distribution of the depth of aortic dissection and the correlation of the dissection depth index with other parameters.

BACKGROUND: In patients with aortic dissection, the aortic wall is separated into two layers along a dissection plane. In this study, a survey was performed to investigate the distribution of the depth of dissection plane and its correlation with other clinical and pathological parameters to help understand and expand the current knowledge of aortic dissection. METHODS: Pathology information system were searched for patients with aortic dissection who had undergone aortic replacement between 2019 and 2022 in Wuhan Asia General Hospital. The depth of dissection plane and dissection depth index were measured in the area around the edge of dissection plane. Correlation between parameters was calculated using Spearman's rank correlation coefficient. RESULTS: 124 patients were included in this study. The depth of dissection plane ranged from 533 to 2335 microns, and the 5th percentile was 778 microns. The dissection depth index ranged from 0.320 to 0.972, and the 5th percentile was 0.503. The correlation coefficients were -0.305 (P=.0007), -0.259 (P=0.0111), 0.188 (P=0.0367), 0.189 (P=0.0359) respectively for male gender, the length of aortic dissection, atherosclerosis, and translamellar mucoid extracellular matrix accumulation. CONCLUSIONS: In 95% of patients with aortic dissection, the depth of dissection plane is larger than 778 microns, and the dissection depth index is greater than 0.503. In other words, aortic dissection rarely occurs in the inner 50.3% of the aortic media. The dissection depth index is negatively correlated with male gender and the length of aortic dissection, and positively correlated with atherosclerosis and translamellar mucoid extracellular matrix accumulation.

Relationship between Depression and Cognitive Inhibition in Men with Heroin or Methamphetamine Use Disorder in First-Time Mandatory Detoxification.

Previous studies have shown that males with substance use disorder (SUD) in their first mandatory detoxification experience high rates of depression. It is unknown whether this high depression incidence contributes to impaired inhibition. In this work, two studies were undertaken to examine the role of depression in cognitive inhibition in heroin and methamphetamine withdrawal. We used the Beck Depression Inventory (BDI) and the self-control scale (SCS) to explore the relationship between depression and impulse inhibition in patients participating in mandatory drug treatment for the first time (Study 1). The results showed that depression negatively predicted impulse inhibition. The Stroop color-word interference task was used to explore the role of patients' depression in their inhibitory abilities (Study 2). The results showed that the high-depression group had weaker inhibition performances in the Stroop color-word interference task compared to the low-depression group. This study shows that cognitive inhibition is weaker in people with high-depression addiction than in those with low depression. This result suggests that attention should be paid to the role of depressive comorbidity when conducting working memory training treatment for substance addiction.

[Responses of radial growth of Pinus yunnanensis to climatic and hydrological factors at different altitudes in Western Yunnan, China]. / æ»‡è¥¿ä¸åŒæµ·æ‹”äº‘å—æ¾å¾„å‘ç”Ÿé•¿å¯¹æ°”å€™æ°´æ–‡è¦ç´ çš„å“åº”.

A tree-ring width chronology (STD) was established using tree-ring cores of Pinus yunnanensis from two sites with different altitudes in Western Yunnan, to study the responses of radial growth to climatic and hydrological factors. The results showed that the radial growth of P. yunnanensis in Western Yunnan was mainly affected by precipitation, temperature and runoff. The radial growth of P. yunnanensis at high altitude (2413.3 m) was controlled primarily by high temperature in summer and runoff in the monsoon season. In contrast, the radial growth of P. yunnanensis at low altitude (1062.6 m) was mainly controlled by precipitation in the growing season and annual runoff. The responses of radial growth of P. yunnanensis at high altitude to temperature change was unstable due to the existence of the temperature threshold. Due to the weakening of the East Asian summer monsoon in the 1980s, the temporal stability of tree growth response at low altitude to precipitation and runoff fluctuated. The radial growth of P. yunnanensis at different altitudes in Western Yunnan was related to the Asian summer monsoon and El Nio-Southern Oscillation.

[Responses of radial growth of Pinus sibirica to climate and hydrology in Altay, Xinjiang, China]. / 新疆阿勒泰地区西伯利亚红松径向生长对气候水文的响应.

Based on a standardized tree-ring width chronology established at Altay, Xinjiang, we examined the climatic and hydrological factors affecting the tree-ring width of Pinus sibirica. The results showed that the tree-ring width chronology of P. sibirica was negatively correlated with the average temperature and the average maximum temperature in May-June of current year and positively correlated with May-June PDSI and January-June precipitation. The tree-ring width chronology of P. sibirica was positively correlated with previous November runoff of the Irtysh River. The radial growth of P. sibirica was affected by temperature and precipitation, with precipitation in early stage of tree growth and temperature in summer being the key climatic factors. The study of the extreme years of chronology showed that the radial growth of P. sibirica was related to ENSO events and global large-scale circulations. By affecting the location of cyclones over Central Asia, ENSO affected water vapor transport to Altay, with consequences on the radial growth of P. sibirica.

[May-July NDVI variation for the middle Qinling Mountains over the past 194 years indicated by tree rings of Pinus tabuliformis]. / æ²¹æ¾æ ‘è½®æŒ‡ç¤ºçš„ç§¦å²­ä¸­éƒ¨è¿‡åŽ»194å¹´5­7月NDVI变化.

Due to the short-term observation record of the normalized difference vegetation index (NDVI), the research on long-term NDVI changes is scarce, which limits our understanding of the impacts of NDVI changes in the context of global warming. In this study, a regional tree-ring chronology was developed based on the tree-ring samples of Pinus tabuliformis in the middle Qinling Mountains. The results showed that tree-ring width of P. tabuliformis was significantly positively correlated with May-July NDVI (r=0.624, P<0.01, n=34). The Sig-Free tree-ring width chronology was used to reconstruct May-July NDVI during the period 1825-2018, which explained 38.9% of the total NDVI variance. Results of spatial analysis showed that the reconstructed series could better represent the NDVI changes in the study area. There were six high NDVI periods and five low NDVI periods in the past 194 years. The vegetation grew best in 2006-2018, indicating vegetation cove-rage in the middle of Qinling Mountains had been improved during the warming hiatus. Low NDVI periods in the reconstruction series were consistent with drought over much of study area. Results of wavelet analysis indicated the existence of 2-4 years and 12-16 years cycles in the reconstruction series. SEA analysis showed that the reconstruction series decreased significantly in the El Nino year, while increased significantly in the first to third years after the La Nina event. The growth of P. tabuliformis was predicted to increase slightly under the SSP2-4.5, SSP3-7.0 and SSP5-8.5 scenarios.

Rickettsia burneti and Brucella melitensis co-infection: a case report and literature review.

Rickettsia is the pathogen of Q fever, Brucella ovis is the pathogen of brucellosis, and both of them are Gram-negative bacteria which are parasitic in cells. The mixed infection of rickettsia and Brucella ovis is rarely reported in clinic. Early diagnosis and treatment are of great significance to the treatment and prognosis of brucellosis and Q fever. Here, we report a case of co-infection Rickettsia burneti and Brucella melitensis. The patient is a 49-year-old sheepherder, who was hospitalized with left forearm trauma. Three days after admission, the patient developed fever of 39.0°C, accompanied by sweating, fatigue, poor appetite and headache. Indirect immunofluorescence (IFA) was used to detect Rickettsia burneti IgM. After 72 hours of blood culture incubation, bacterial growth was detected in aerobic bottles, Gram-negative bacilli were found in culture medium smear, the colony was identified as Brucella melitensis by mass spectrometry. Patients were treated with doxycycline (100 mg bid, po) and rifampicin (600 mg qd, po) for 4 weeks. After treatment, the symptoms disappeared quickly, and there was no sign of recurrence or chronic infection. Q fever and Brucella may exist in high-risk practitioners, so we should routinely detect these two pathogens to prevent missed diagnosis.

An Integrated Compensation Method for the Force Disturbance of a Six-Axis Force Sensor in Complex Manufacturing Scenarios.

As one of the key components for active compliance control and human-robot collaboration, a six-axis force sensor is often used for a robot to obtain contact forces. However, a significant problem is the distortion between the contact forces and the data conveyed by the six-axis force sensor because of its zero drift, system error, and gravity of robot end-effector. To eliminate the above disturbances, an integrated compensation method is proposed, which uses a deep learning network and the least squares method to realize the zero-point prediction and tool load identification, respectively. After that, the proposed method can automatically complete compensation for the six-axis force sensor in complex manufacturing scenarios. Additionally, the experimental results demonstrate that the proposed method can provide effective and robust compensation for force disturbance and achieve high measurement accuracy.

A Camera Intrinsic Matrix-Free Calibration Method for Laser Triangulation Sensor.

Laser triangulation sensors (LTS) are widely used to acquire depth information in industrial applications. However, the parameters of the components, e.g., the camera, of the off-the-shelf LTS are typically unknown. This makes it difficult to recalibrate the degenerated LTS devices during regular maintenance operations. In this paper, a novel one-dimensional target-based camera intrinsic matrix-free LTS calibration method is proposed. In contrast to conventional methods that calibrate the LTS based on the precise camera intrinsic matrix, we formulate the LTS calibration as an optimization problem taking all parameters of the LTS into account, simultaneously. In this way, many pairs of the camera intrinsic matrix and the equation of the laser plane can be solved and different pairs of parameters are equivalent for displacement measurement. A closed-form solution of the position of the one-dimensional target is proposed to make the parameters of the LTS optimizable. The results of simulations and experiments show that the proposed method can calibrate the LTS without knowing the camera intrinsic matrix. In addition, the proposed approach significantly improves the displacement measurement precision of the LTS after calibration. In conclusion, the proposed method proved that the precise camera intrinsic matrix is not the necessary condition for LTS displacement measurement.

Efficient perturbation-tracking method for directly probing the spectral phonon properties from molecular dynamics simulations.

Existing methods for directly extracting the spectral phonon properties from molecular dynamics (MD) simulations, like the normal mode analysis (NMA) and spectral energy density analysis, all require a very long simulation time to produce reliable results with good convergence. So far, these methods are mainly applied in studies using small systems and with empirical potentials, as the heavy computational load has greatly hindered their further applications. Here we propose a perturbation-tracking (PT) method for directly probing the mode-wise phonon anharmonic frequencies and lifetimes. We show that results obtained from our method are in excellent agreement with those from the conventional NMA approach, using Si as the model material system. Comparing with the NMA approach, the PT method offers a greater accuracy and significant improvement of efficiency. It takes an average of two orders of magnitude and up to three orders of magnitude less simulation time to obtain the same lifetime result of a phonon mode with intermediate to high accuracy. Meanwhile, our method preserves all the dynamics of probed phonon mode from a particular state, which means it is capable of studying the transient thermal transport processes in a nonequilibrium system. Besides the exceptional efficiency, our method also comes with freedom to choose to probe only those modes of interest. This makes it ideal for use with large systems and in computationally demanding applications, such as ab initio MD simulations. Moreover, the PT method we propose here is very straightforward and easy to implement.