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1.
Appl Opt ; 63(12): 3178-3185, 2024 Apr 20.
Artículo en Inglés | MEDLINE | ID: mdl-38856464

RESUMEN

Silicon photonics devices benefit greatly from a partially etched platform and inverse design. Herein, we propose a bi-layer polarization splitter and rotator with a topology pattern and demonstrate it on a silicon-on-insulator platform. Our device exhibits a significantly reduced physical footprint of only 2µm×6µm, compared to traditional directional couplers and tapered waveguides. The device accomplishes the functions of polarization conversion and separation in such a compact design without redundant tapered or bending waveguides. The tested minimum insertion loss with the fabrication batch reaches 0.57 and 0.67 dB for TE and TM modes, respectively. The TE mode demonstrates a wider bandwidth and lower ILs than the TM modes, averaging around 1 dB from 1530 to 1565 nm. The M modes exhibit approximately 2 dB ILs at the same wavelength range, decreasing to about 1 dB between 1565 and 1580 nm. Improved designs and fabrication conditions strongly suggest the potential for further performance enhancement in the device. This successful initiative validates the exceptional performance resulting from the integration of the partially etched platform and inverse design, providing valuable insights for future photonic integrated device designs.

2.
Environ Res ; 257: 119243, 2024 May 27.
Artículo en Inglés | MEDLINE | ID: mdl-38810820

RESUMEN

Brownification in aquatic ecosystems under global change has attracted attention. The composition and quantity of dissolved organic matter transported from various land use types to lakes differ significantly, causing varying ecological effects of lake brownification by region. Bacterial communities make a significant contribution to the material cycle of ecosystems and are sensitive to environmental changes. In this study, a series of mesocosm systems were used to simulate forest lakes and urban lakes with different degrees of brownification, and a high-throughput amplicon sequencing technique was used to explore the changes in the composition, structure, and function of bacterial communities in shallow lakes undergoing brownification. Principal coordinate analysis (PCoA) and Jensen‒Shannon distance typing analysis both indicated significant differences in bacterial communities between forest lakes and urban lakes. The α diversity of bacterial communities in urban lakes increased with the degree of brownification. However, whether forest lakes or urban lakes, brownification increased the abundance of carbon cycling-related bacterial phyla (Proteobacteria, Poribacteria, and Chloroflexi) and nitrogen cycling-related bacterial genera (Microbacteriaceae, Limnohabitans, Comamonadaceae, Bacillus, and Rhizobiales_Incertae_Sedis). Additionally, the carbon and nitrogen cycling functions of bacterial communities in forest lakes are dominant, while those in urban lakes are dominated by functions related to light. Our study has preliminarily revealed that lake brownification promotes the growth of carbon and nitrogen cycling microorganisms, providing a new paradigm for understanding the response of lake ecosystems in different catchment areas to environmental changes and the carbon and nitrogen cycling processes in shallow lake ecosystems.

3.
Int J Biol Macromol ; 259(Pt 2): 129296, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38199549

RESUMEN

In this work the identification of peptides derived from quinoa proteins which could potentially self-assemble, and form hydrogels was carried out with TANGO, a statistical mechanical based algorithm that predicts ß-aggregate propensity of peptides. Peptides with the highest aggregate propensity were subjected to gelling screening experiments from which the most promising bioactive peptide with sequence KIVLDSDDPLFGGF was selected. The self-assembling and hydrogelation properties of the C-terminal amidated peptide (KIVLDSDDPLFGGF-NH2) were studied. The effect of concentration, pH, and temperature on the secondary structure of the peptide were probed by circular dichroism (CD), while its nanostructure was studied by transmission electron microscopy (TEM) and small-angle neutron scattering (SANS). Results revealed the existence of random coil, α-helix, twisted ß-sheet, and well-defined ß-sheet secondary structures, with a range of nanostructures including elongated fibrils and bundles, whose proportion was dependant on the peptide concentration, pH, or temperature. The self-assembly of the peptide is demonstrated to follow established models of amyloid formation, which describe the unfolded peptide transiting from an α-helix-containing intermediate into ß-sheet-rich protofibrils. The self-assembly is promoted at high concentrations, elevated temperatures, and pH values close to the peptide isoelectric point, and presumably mediated by hydrogen bond, hydrophobic and electrostatic interactions, and π-π interactions (from the F residue). At 15 mg/mL and pH 3.5, the peptide self-assembled and formed a self-supporting hydrogel exhibiting viscoelastic behaviour with G' (1 Hz) ~2300 Pa as determined by oscillatory rheology measurements. The study describes a straightforward method to monitor the self-assembly of plant protein derived peptides; further studies are needed to demonstrate the potential application of the formed hydrogels in food and biomedicine.


Asunto(s)
Chenopodium quinoa , Nanoestructuras , Péptidos/química , Hidrogeles/química , Estructura Secundaria de Proteína , Nanoestructuras/química , Dicroismo Circular
4.
Opt Lett ; 48(15): 3873-3876, 2023 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-37527071

RESUMEN

We design, fabricate, and characterize a compact dual-mode waveguide crossing on a silicon-on-insulator platform. The dual-mode waveguide crossing with high performance is designed by utilizing the adjoint shape optimization. This adjoint-method-based optimization algorithm is computationally efficient and yields the optimal solution in fewer iterations compared with other iterative schemes. Our proposed dual-mode waveguide crossing exhibits low insertion loss and low crosstalk. Experimental results show that the insertion losses at the wavelength of 1550 nm are 0.83 dB and 0.50 dB for TE0 and TE1 modes, respectively. The crosstalk is less than -20 dB for the two modes over a wavelength range of 80 nm. The footprint of the whole structure is only 5 × 5 µm2.

5.
Front Microbiol ; 14: 1188229, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37389339

RESUMEN

Introduction: Microbes play key roles in maintaining soil ecological functions. Petroleum hydrocarbon contamination is expected to affect microbial ecological characteristics and the ecological services they provide. In this study, the multifunctionalities of contaminated and uncontaminated soils in an aged petroleum hydrocarbon-contaminated field and their correlation with soil microbial characteristics were analyzed to explore the effect of petroleum hydrocarbons on soil microbes. Methods: Soil physicochemical parameters were determined to calculate soil multifunctionalities. In addition, 16S high-throughput sequencing technology and bioinformation analysis were used to explore microbial characteristics. Results: The results indicated that high concentrations of petroleum hydrocarbons (565-3,613 mg•kg-1, high contamination) reduced soil multifunctionality, while low concentrations of petroleum hydrocarbons (13-408 mg•kg-1, light contamination) might increase soil multifunctionality. In addition, light petroleum hydrocarbon contamination increased the richness and evenness of microbial community (p < 0.01), enhanced the microbial interactions and widened the niche breadth of keystone genus, while high petroleum hydrocarbon contamination reduced the richness of the microbial community (p < 0.05), simplified the microbial co-occurrence network, and increased the niche overlap of keystone genus. Conclusion: Our study demonstrates that light petroleum hydrocarbon contamination has a certain improvement effect on soil multifunctionalities and microbial characteristics. While high contamination shows an inhibitory effect on soil multifunctionalities and microbial characteristics, which has significance for the protection and management of petroleum hydrocarbon-contaminated soil.

6.
Opt Lett ; 48(10): 2607-2610, 2023 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-37186720

RESUMEN

We experimentally demonstrate a hybrid mode division multiplexer (MDM) based on asymmetric directional couplers (ADCs) without transition tapers in between. The proposed MDM can couple five fundamental modes from access waveguides into the bus waveguide as the hybrid modes (TE0, TE1, TE2, TM0, and TM1). To eliminate the transition tapers between cascaded ADCs as well as to enable arbitrary add-drop to the bus waveguide, we maintain the bus waveguide width to be the same, while a partially etched subwavelength grating is introduced to reduce the effective refractive index of the bus waveguide. The experimental results demonstrate a working bandwidth of up to 140 nm.

7.
Huan Jing Ke Xue ; 44(3): 1497-1507, 2023 Mar 08.
Artículo en Chino | MEDLINE | ID: mdl-36922210

RESUMEN

Microorganisms play an important role in the urban river nitrogen cycle. Due to the three-dimensional fluidity of river water, it is necessary to clarify the vertical distribution of community composition and nitrogen metabolism functions of microorganisms and discover how hydrodynamic factors influence microorganism sources and community composition. Based on 16S rRNA high-throughput sequencing technology, the bacteria community composition and nitrogen metabolism function of water and sediment in the North Canal at Tongzhou District Beijing City were analyzed. The effect of environmental and hydrodynamic factors on community composition and sources were studied. The results showed that the α diversity of sediment was significantly higher than that of water. Proteobacteria was the most abundant phylum, which accounted for 54.72% and 32.36% in water and sediment, respectively. Functional prediction conducted using PICRUSt2 showed that the studied North Canal had an abundance of nitrogen metabolism ability, and 47 genes related to the nitrogen cycle were obtained. Water and sediment microorganisms had a similar distribution of nitrogen metabolism functions. The copy number of genes involved with denitrification, nitrogen assimilation, and dissimilation-reduction were high, whereas the abundance of genes related to biological nitrogen fixation and nitrification were relatively low. Source tracking analysis showed that bacteria in the water that originated from upstream, neighboring sides, and sediment were 60.05%, 37.93%, and 1.05%, respectively. The amounts of bacteria in sediment that migrated from upstream, neighboring sides, and water were 50.16%, 45.55%, and 1.55%, respectively. Environmental factors, hydrodynamic conditions, and their interactions explained water bacteria community composition for 44.22%, 3.21%, and 15.60%, respectively. For sediment bacteria, the degree of explanation was 13.05%, 1.56%, and 8.51%, respectively. This indicated that environmental factors and hydrodynamic factors controlled the community composition and nitrogen cycle functions together.


Asunto(s)
Bacterias , Ríos , Ríos/microbiología , ARN Ribosómico 16S/genética , Nitrógeno/metabolismo , Agua , Sedimentos Geológicos/microbiología
8.
Anticancer Res ; 43(2): 939-942, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36697075

RESUMEN

BACKGROUND: The clear-cell variant of mucoepidermoid carcinoma (MEC) involving minor salivary glands is extremely rare in children. CASE REPORT: We report a case of clear-cell variant MEC in the minor salivary gland in a 10-year-old boy who presented with a mass of the right hard palate. Fine-needle aspiration showed features suggestive of clear-cell variant of MEC. Microscopically, the tumor cells showed predominant clear cells and scattered mucous cells. There was increased mitotic activity (6/mm2). No tumor necrosis or nuclear pleomorphism was identified. The tumor cells were positive for cytokeratin 7 (CK7), tumor protein p63, P40 (ΔNp63), CK5/6 and mucicarmine. Rearrangement of mastermind-like transcriptional coactivator 2 (MAML2) (11q21) gene was present in the tumor cells by fluorescence in situ hybridization, supporting the diagnosis of an intermediate-grade clear-cell variant of MEC. A right infrastructure maxillectomy for palate carcinoma with negative margins was performed. Grossly, the tumor was a 2.1 cm well-circumscribed, friable, pale tan mass with focal areas of cystic change. The final pathological diagnosis was clear-cell variant of MEC, intermediate grade, pT2. Post surgery, the patient recovered and was doing well, with no tumor recurrence or metastasis at the 6-month follow-up. CONCLUSION: To the best of our knowledge, this is the first documented case of clear-cell variant MEC in a child. Due to low to intermediate tumor grade, an overtly aggressive treatment should be avoided in a child.


Asunto(s)
Carcinoma Mucoepidermoide , Neoplasias de las Glándulas Salivales , Masculino , Niño , Humanos , Proteínas de Unión al ADN/genética , Transactivadores/genética , Carcinoma Mucoepidermoide/diagnóstico , Carcinoma Mucoepidermoide/genética , Carcinoma Mucoepidermoide/cirugía , Hibridación Fluorescente in Situ , Recurrencia Local de Neoplasia , Factores de Transcripción/genética , Hueso Paladar/patología , Neoplasias de las Glándulas Salivales/genética , Neoplasias de las Glándulas Salivales/cirugía , Neoplasias de las Glándulas Salivales/química
9.
J Environ Manage ; 325(Pt B): 116476, 2023 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-36323113

RESUMEN

Artificial flow regulation is an important measure to alleviate water shortages and improve the ecological quality of river basins. Dissolved organic matter (DOM) plays a crucial role in the carbon cycle and regulates biogeochemical and ecological processes in aquatic systems. Among the numerous studies on the effects of anthropogenic activities on the quality and quantity of river DOM, few studies have focused on the influence of different artificially regulated flow on the composition, source, and fate of fluvial DOM. This study aims to elucidate the impact of different artificial regulation modes of river flows on the source, migration, and transformation of DOM. The optical properties of DOM were used to explore the temporal and spatial distribution characteristics of DOM in the Yongding River Basin, where artificial regulation of river flows by cross-basin and inner-basin water transfers were implemented. Excitation-emission matrix fluorescence spectroscopy coupled with parallel factor analysis revealed four fluorescent substances of DOM in the water: one microbial humic-like (C1), one terrestrial humic-like (C2), one non-point source pollution humic-like (C4), and one tryptophan-like (C3) substance. Due to cross-basin water transfer from the Yellow River, the flow is the highest (21.79 m3/s) during spring, which was the reason that the signal of C2 was stronger during spring (71.45 QSU) compared to summer (57.12 QSU) and autumn (51.78 QSU). Due to inner-basin water transfer from upstream reservoirs, C3 derived from autochthonous sources were higher during autumn (130.81 QSU) than during spring (77.17 QSU) and summer (93.16 QSU). With no water transfer, more C1 were present at higher temperatures during summer (141.51 QSU) than during spring (126.73 QSU) and autumn (128.8 QSU). Moreover, C4 originating from urban and/or agricultural non-point source runoff increased during summer (57.07 QSU) than during spring (33.29 QSU) and autumn (52.27 QSU) because of increased rainfall. The different modes of artificial regulation of river flows changed the hydrological characteristics of the basin, which in turn altered the temporal and spatial distribution characteristics of the quantity and quality of DOM. The finding of this study can help promote the development of appropriate management strategies for artificial regulation of river flows in the basin. Furthermore, this study provides a basis for investigating the effects of different artificial flow regulations on the carbon cycles and ecological risks of rivers in the basin.


Asunto(s)
Materia Orgánica Disuelta , Ríos , Ríos/química , Estaciones del Año , Espectrometría de Fluorescencia , Agricultura , China
10.
Artículo en Inglés | MEDLINE | ID: mdl-36497545

RESUMEN

Mapping spatial distribution of soil contaminants at contaminated sites is the basis of risk assessment. Hotspots can cause strongly skewed distribution of the raw contaminant concentrations in soil, and consequently can require suitable normalization prior to interpolation. In this study, three normalization methods including normal score, Johnson, and Box-Cox transformation were performed on the concentrations of two low-molecular weight (LMW) PAHs (i.e., acenaphthene (Ace) and naphthalene (Nap)) and two high-molecular weight (HMW) PAHs (i.e., benzo(a)pyrene (BaP) and benzo(b)fluoranthene (BbF)) in soils of a typical coking plant in North China. The estimating accuracy of soil LMW and HMW PAHs distribution using ordinary kriging with different normalization methods was compared. The results showed that all transformed data passed the Kolmogorov-Smirnov test, indicating that all three data transformation methods achieved normality of raw data. Compared to Box-Cox-ordinary kriging, normal score-, and Johnson-ordinary kriging had higher estimating accuracy of the four soil PAHs distribution. In cross-validation, smaller root-mean-square error (RMSE) and mean error (ME) values were observed for normal score-ordinary kriging for both LMW and HMW PAHs compared to Johnson- and Box-Cox-ordinary kriging. Thus, normal score transformation is suitable for alleviating the impact of hotspots on estimating accuracy of the four selected soil PAHs distribution at this coking plant. The findings can provide insights into reducing uncertainty in spatial interpolation at PAHs-contaminated sites.


Asunto(s)
Coque , Hidrocarburos Policíclicos Aromáticos , Contaminantes del Suelo , Suelo , Contaminantes del Suelo/análisis , Peso Molecular , Monitoreo del Ambiente/métodos , Hidrocarburos Policíclicos Aromáticos/análisis , Plantas , China
11.
Curr Res Food Sci ; 5: 2061-2069, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36387599

RESUMEN

Gelation is critical in many food applications of plant proteins. Herein, limited hydrolysis by Alcalase was used to promote thermally induced gelation of quinoa protein isolates (QPI). Mechanical properties of various QPI gels were characterised by small and large oscillatory shear deformation rheology while the microstructural features were observed by confocal laser scanning microscopy (CLSM). Both the gel strength and microstructure are strongly related to the hydrolysis time. The maximum gel strength (∼100 Pa) was achieved after Alcalase hydrolysis for 1 min, which was ∼20 folds higher than that of untreated QPI. Extended hydrolysis up to 5 min progressively decreased the gel strength. A string-like interconnected protein network was formed after proteolysis. The change of gel strength with hydrolysis time correlated well to the G' 20°C/G' 90°C value and results of intrinsic fluorescence and surface hydrophobicity. The G' 20°C/G' 90°C value is sensitive to hydrogen bonds formation while the intrinsic fluorescence and surface hydrophobicity are associated with protein unfolding and exposure of hydrophobic groups. Therefore, both hydrogen bonding and hydrophobic interactions are critical in improving the gel strength of QPI hydrolysates. Finally, FTIR analysis revealed that protein secondary structures are affected by the proteolysis and formation of inter-molecular hydrogen bonds between polypeptides. This study provides an efficient strategy for improving thermally induced gelation of QPI and enables a deep understanding of QPI gelation mechanism induced by Alcalase hydrolysis.

12.
Perm J ; 26(4): 14-20, 2022 12 19.
Artículo en Inglés | MEDLINE | ID: mdl-36117248

RESUMEN

Introduction Accurately determining the supply and demand of hospital beds for new admissions can help prevent adverse patient outcomes. Quantitative analysis of modern electronic medical record data can help predict supply and demand for unoccupied staffed hospital beds (SEDs) and aid in eliminating human approximations, standardizing daily work through concrete and objective data. The purpose of this study was to reduce variability and human error in predicting the number of SEDs needed. Methods In this study,the authors analyzed bed calculator data from a medium-sized, suburban medical center to evaluate the efficacy of a unique bed calculator prediction tool to determine the need for SEDs. The calculator aggregates multiple key reference factors available through the bed calculator system into a cohesive linear regression model. Results Compared with human estimation, the authors found that the bed calculator is able to predict the number of SEDs needed more effectively. That being said, there was no significant difference in the average boarding times pre- and postintervention, indicating that the bed calculator did not result in decreased boarding times for patients. Discussion These findings establish the efficacy of the bed calculator and its ability to align bed supply and demand. Because patient boarding times depend on the system's patient flow management, future studies should focus on how to improve various streams of communication and coordination.


Asunto(s)
Servicio de Urgencia en Hospital , Admisión del Paciente , Humanos , Tiempo de Internación , Hospitalización , Hospitales
13.
Comput Math Methods Med ; 2022: 4118911, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35693257

RESUMEN

Objective: To analyze the diagnostic value of luteinizing hormone (LH) peak value of the gonadotropin-releasing hormone (GnRH) stimulation test for girls with precocious puberty and its correlation with body mass index (BMI). Methods: A total of 230 girls with precocious puberty who came to our hospital for testing from June 2019 to June 2021 were selected and divided into a true group (n = 130) and sham group (n = 100) according to the results of the GnRH stimulation test. According to the BMI, the true group was further divided into a normal group (48 cases), overweight group (43 cases), and obese group (39 cases). The GnRH stimulation test was performed on all subjects, and the basal value and peak value of LH and the basal value and peak value of follicle-stimulating hormone (FSH) were recorded. The general data and serological indexes of the true group and the sham group were compared. Indicators of the GnRH stimulation test, breast stage, bone age, BMI, uterine volume, ovarian volume, and serological indicators (leptin, sex hormone-binding protein (SHBG), and adiponectin (APN)) were compared among the normal group, the overweight group, and the obese group. Results: There were no significant differences in age and breast stage between the true group and the sham group (P > 0.05). There were statistically significant differences in bone age, BMI, uterine volume, and ovarian volume between the two groups (P < 0.05). The LH base value, LH peak value, FSH base value, and FSH peak value in the true group were higher than those in the sham group, and the differences were statistically significant (P < 0.05). ROC curve analysis showed that the AUC of LH peak value in diagnosing girls with precocious puberty was 0.973, which was higher than 0.895, 0.875, and 0.912 of LH base value, FSH base value, and FSH peak value, respectively. There were statistically significant differences in LH base value, LH peak value, FSH base value, breast development stage, bone age, BMI, SHBG, leptin, and APN among the normal group, overweight group, and obese group (P < 0.05), but there were no significant differences in FSH peak value, uterine volume, and ovarian volume among the three groups (P > 0.05). There was a negative correlation between BMI, LH peak value, and FSH base value (P < 0.05), but there was no significant correlation between BMI and FSH peak value (P > 0.05). Conclusion: The LH peak value of the GnRH stimulation test has high diagnostic value for girls with precocious puberty, and BMI is negatively correlated with the LH peak value of CPP children.


Asunto(s)
Pubertad Precoz , Índice de Masa Corporal , Niño , Femenino , Hormona Folículo Estimulante , Hormona Liberadora de Gonadotropina , Humanos , Leptina , Hormona Luteinizante/metabolismo , Obesidad/diagnóstico , Sobrepeso , Pubertad Precoz/diagnóstico , Pubertad Precoz/metabolismo
14.
J Contam Hydrol ; 248: 104017, 2022 06.
Artículo en Inglés | MEDLINE | ID: mdl-35523047

RESUMEN

n-Alkanes, the main component of diesel fuel, are common light non-aqueous phase liquids (LNAPLs) that threaten ecological security. The subsurface from vadose zone, through fluctuating zone, to saturated zone, is a critical multi-interface earth layer which significantly affects the biodegradation processes of n-alkanes. A pilot-scale diesel contaminated aquifer column experiment has been undertaken to investigate the variations of bacterial community and alkane monooxygenase (alkB) gene abundance in these zones due to water-table fluctuations. The n-alkanes formed a layer immediately above the water table, and when this was raised, they were carried upwards through the fluctuating zone into the vadose zone. Water content and n-alkanes component C10-C12 are main factors influencing bacterial community variation in the vadose zone, while C10-C12 is a key driving factor shaping bacterial community in the fluctuating zone. The most abundant bacterial phyla at all three zones were Proteobacteria, Firmicutes and Actinobacteria, but moisture-niche selection determined their relative abundance. The intermittent wetting cycle resulted in higher abundance of Proteobacteria, and lower abundance of Actinobacteria in the vadose and fluctuating zones in comparison to the control column with a static water-table. The abundances of the alkB gene variants were relatively uniform in different zones, probably because the bacterial populations harboring alkB gene are habituated to biogenic n-alkanes rather than responding to diesel fuel contamination. The variation in the bacterial populations with height due to moisture-niche selection had very little effect on the alkB gene abundance, possibly because numerous species in both phyla (Proteobacteria and Actinobacteria) carry an alkB gene variant. Nevertheless, the drop in the water table caused a short-term spike in alkB gene abundance in the saturated zone, which is most likely associated with transport of solutes or colloids from the fluctuating zone to bacteria species in the saturated zone, so a fluctuating water table could potentially increase n-alkane biodegradation function.


Asunto(s)
Alcanos , Agua Subterránea , Bacterias/genética , Bacterias/metabolismo , Biodegradación Ambiental , Citocromo P-450 CYP4A/genética , Citocromo P-450 CYP4A/metabolismo , Gasolina , Estaciones del Año
16.
J Colloid Interface Sci ; 608(Pt 2): 1286-1296, 2022 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-34758419

RESUMEN

The in-vitro gastrointestinal digestion behaviour of an oil-in-water emulsion with an interface consisting of nano-sized droplets coated with caseinate particles, referred to as a droplet-stabilised emulsion (DSE), was explored using the human gastric simulator and pH-stat models. A caseinate-particle-stabilised emulsion (PSE) was used as a control, with a similar droplet size distribution and the same composition as the DSE. The nanodroplet-stabilised interface of the DSE was preserved during the first 180 min of gastric digestion. During 240 min, the droplet sizes of the DSE and the PSE increased from 22.71 ± 1.14 to 63.34 ± 6.57 µm and from 17.98 ± 1.16 to 85.11 ± 9.35 µm respectively. The small droplet size of the DSE that was released from the gastric phase contributed to slightly higher total free fatty acid (FFA) release (56.18 ± 3.55%) than that from the PSE (49.4 ± 2.67%). The FFA release rate of the DSE (1.21 % min-1) was greater than that of the PSE (1.06 % min-1) during the first 30 min of small intestinal digestion; similar FFA release rates (0.5 µmol s-1 m-2 × 10-4) were obtained for both emulsions beyond 30 min of digestion. This study provides new information on lipid digestion using a novel interfacial layer that was stabilised with nanodroplets.


Asunto(s)
Digestión , Intestinos , Caseínas , Emulsiones , Humanos , Lípidos , Tamaño de la Partícula
17.
Opt Express ; 29(21): 33728-33740, 2021 Oct 11.
Artículo en Inglés | MEDLINE | ID: mdl-34809179

RESUMEN

Fiber couplers usually take a lot of space on photonic integrated circuits due to the large mode-size mismatch between the waveguide and fiber, especially when a fiber with larger core is utilized, such as a few-mode fiber. We demonstrate experimentally that such challenge can be overcome by an ultra-compact mode-size converter with a footprint of only 10 µm. Our device expands TE0 and TE1 waveguide modes simultaneously from a 1-µm wide strip waveguide to an 18-µm wide slab on a 220-nm thick silicon-on-insulator, with calculated losses of 0.75 dB and 0.68 dB, respectively. The fabricated device has a measured insertion loss of 1.02 dB for TE0 mode and 1.59 dB for TE1 mode. By connecting the ultra-compact converter with diffraction grating couplers, higher-order modes in a few-mode fiber can be generated with a compact footprint on-chip.

18.
Opt Express ; 29(18): 28066-28077, 2021 Aug 30.
Artículo en Inglés | MEDLINE | ID: mdl-34614945

RESUMEN

In this work, we propose an ultra-broadband and ultra-compact polarization beam splitter (PBS) on a standard silicon-on-isolator platform. Assisted by a tapered subwavelength-grating waveguide and a slot waveguide, the working bandwidth of the directional-coupler-based PBS covers the entire O-, E-, S-, C-, L- and U-bands and the coupling length is only 4.6 µm. The insertion losses (ILs) of the device are simulated to be less than 0.8 dB and the extinction ratios (ERs) are larger than 10.9 dB at the wavelength range of 1260-1680 nm for both TE and TM polarizations. The experimental results show the average ILs are less than 1 dB for both polarizations at our measured wavelength ranges, which are consistent with the simulation results. It has the largest 1-dB bandwidth among all the reported broadband PBSs to the best of our knowledge.

19.
Opt Lett ; 46(13): 3308-3311, 2021 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-34197443

RESUMEN

We experimentally demonstrate a novel, to the best of our knowledge, three-port grating coupler (TPGC) for dual-wavelength-band operation. The TPGC can couple light to/from two ports for S/C-band with polarization diversity and a third port for O-band. Such a coupling scheme could be applied in an integrated wavelength-division-multiplexing passive optical network (PON) unit, benefiting a polarization-diverse receiver for downstream S/C-band and transmitter for upstream O-band. The device is fabricated on a multi-project wafer, with peak coupling efficiency measured to be -3.8dB and -5.4dB for O-band and S/C-band, respectively. We also present a proof-of-concept demonstration for 10-Gb/s PON transmission based on the TPGC.

20.
Isotopes Environ Health Stud ; 57(4): 350-367, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34156896

RESUMEN

Nitrate pollution has become an environmental problem of global concern. One effective way for controlling the nitrate pollution of water is to identify the pollution source and reduce the input of nitrate. This study traces and quantifies the sources of nitrate contamination to groundwater and surface water in the northeastern suburbs of Beijing, where an emergency groundwater source zone is located. Nitrogen and oxygen stable isotope analysis, geospatial analysis techniques, principal component analysis, correlation analysis, and a Bayesian isotope mixing model were used to achieve our goals. The results show that the main sources of nitrate pollution in groundwater were manure and sewage (M&S) (42.6 %) > soil nitrogen (SN) (26.6 %) > NH4+ in fertilizer and rain (NHF&R) (24.5 %) > NO3- fertilizer (NOF) (5.0 %) > NO3- in atmospheric deposition (NAD) (1.3 %), and main sources of nitrate in surface water were M&S (28.8 %) > SN (20.4 %) > NAD (19.8%) > NOF (16.5%) > NHF&R (14.5 %). Due to the high permeability of the aquifer in the study area, there was a strong hydraulic connection between groundwater and surface water. The discharge of treated wastewater (reclaimed water) into the mostly dried river channel in the study area might aggravate nitrate pollution in the groundwater.


Asunto(s)
Agua Potable/análisis , Monitoreo del Ambiente/estadística & datos numéricos , Modelos Estadísticos , Nitratos/análisis , Contaminantes Químicos del Agua/análisis , Teorema de Bayes , Beijing , Monitoreo del Ambiente/métodos , Agua Subterránea/análisis , Estiércol , Isótopos de Nitrógeno , Isótopos de Oxígeno , Análisis de Componente Principal , Aguas del Alcantarillado , Contaminación del Agua/análisis
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