[Functional state of various organs in patients after replantation an revascularization of large segments of the extremities]. / Funktsional'noe sostoianie nekotorykh organov u bol'nykh posle replantatsii i revaskuliarizatsii krupnykh segmentov konechnostei.

The authors have analysed the results of functional examinations of some organs in 26 patients after replantation (9 cases) following complete (4) and subtotal (5) avulsion and after revascularization (17 cases) of large segments following severe mechanical injuries. It has been demonstrated that 4 to 6 months after the operation the disturbances in the electric activity of the brain and in the secretory and secretory functions of the kidneys have a reversible character and regress 2 to 5 years later. No functional disturbances concern-ing the thyroid gland, the cardiovascular system and the liver have been revealed in the patients who were examined 4 to 5 months following the surgery. The authors believe that after replantation or revascularization of a large segment of an extremity which was devoid of circulation for 5 to 7 hours the patients should be under medical control for the activity of the inner organs, first of all the brain and the kidneys for at least 2 paors to be able to correct their functioning in good time.

[Radioimmune method of determining the concentration of digoxin in the blood during treatment of patients with cardiac insufficiency]. / Radioimmunnyi metod opredeleniia kontsentratsii digoksina v korvi pri lechenii bol'nykh s serdechnoi nedostatochnost'iu

Digoxin concentrations were studied in the blood serum of 128 patients with cardiac insufficiency of different etiology (acute myocardial infarction, postinfarction cardiosclerosis, mitral valve disease). Radioimmunoassay with standard kits was employed, the kits containing 125 I-labelled Digoxin. Mean concentrations of Digoxin were determined in the blood serum corresponding to different maintenance doses of the drug. It was found that signs of overdosage usually appear with concentrations exceeding 2.5 ng/ml. Disorders in the renal excretory function in patients with severe edematous syndrome help a prompt cumulation of Digoxin and the development of glucoside intoxication. Some patients demonstrated a reduced Digoxin tolerance in the acute period of their myocardial infarction. The advantages of the radioimmunoassay, especially in severely ill patients with cardiac pathology are emphasized.

[Treatment of circulatory insufficiency in patients with ischemic heart disease with digoxin and determination of its concentration in the blood serum by radioisotope method]. / Lechenie nedostatochnosti krovoobrashcheniia u bol'nykh ishemicheskoi bolezn'iu serdtsa digoksinom s opredelenim ego kontsentratsii v syvorotke krovi radioizotopnym metodom

The radioisotope method with Rb86 was used for determining in vitro the serum concentration of Digoxin. The study was conducted in 57 patients with cardiac insufficiency in the acute period of myocardial infarction and with post infarction cardiosclerosis. The mean values of Digoxin concentration depending on the daily maintenance dose were obtained. The direct correlation between the amount of the drug taken and the content of the drug in the blood serum was proved. Digoxin intoxication was found to develop in cases of its content exceeding the mean level for the given dosage (4 patients), however, in 2 patients signs of intoxication developed with a low concentration of Digoxin. The causes favouring the development of intoxication are discussed.