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DNA Repair (Amst) ; 140: 103697, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38878563

RESUMEN

Tonicity-responsive enhancer binding protein (TonEBP) is a stress-responsive protein that plays a critical role in the regulation of gene expression and cellular adaptation to stressful environments. Recent studies uncovered the novel role of TonEBP in the DNA damage response, which significantly impacts genomic stability. This review provides a comprehensive overview of the novel role of TonEBP in DNA damage repair, including its involvement in the DNA damage bypass pathway and the recognition and resolution of DNA damage-induced R-loop structures.


Asunto(s)
Daño del ADN , Reparación del ADN , Estructuras R-Loop , Humanos , Animales , Inestabilidad Genómica , ADN/metabolismo
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