The Impact of Morphological Awareness on Reading and Spelling / O Impacto da Consciência Morfológica na Leitura e na Ortografia

ABSTRACT: Morphological awareness is characterized by the ability to intentionally reflect and manipulate morphemes. The present study aimed to characterize the development of morphological awareness in school-age children and to analyze its impact on reading and spelling. The sample was comprised of 60 children with typical language development in Portuguese primary schools with a mean age of 8.6 (standard deviation = 0.1), 30of which attended the 2nd grade and 30 the 4th grade. The data was analyzed considering the use of language assessment instruments, reading and spelling and morphological awareness tests adapted from other studies. The results showed a significant difference in morphological awareness between the 2nd grade and the 4th grade. Although with different statistical proportions, there was a positive correlation between morphological awareness and reading, and between this metalinguistic capacity and spelling in both groups. An association is suggested between morphological awareness and reading and spelling and a difference in this correlation between the two degrees.

RESUMO: A consciência morfológica é caracterizada pela capacidade de refletir e manipular intencionalmente os morfemas. O presente estudo visou caracterizar o desenvolvimento da consciência morfológica em crianças em idade escolar e analisar o seu impacto na leitura e na ortografia. A amostra foi composta por 60 crianças portuguesas com desenvolvimento linguístico típico a frequentar o 1º ciclo do Ensino Básico, com uma média de idades de 8,6 anos (desvio padrão = 0.1), 30 das quais frequentam o 2º ano e 30 o 4º ano. Os dados foram analisados com recurso a instrumentos de avaliação linguística, leitura e ortografia e testes de consciência morfológica adaptados de outros estudos. Os resultados mostraram uma diferença significativa na consciência morfológica entre o 2º ano e o 4º ano. Embora com diferentes proporções estatísticas, houve uma correlação positiva entre consciência morfológica e leitura, e entre esta capacidade metalinguística e ortográfica em ambos os grupos. É sugerida uma associação entre consciência morfológica e leitura e ortografia e uma diferença nesta correlação entre os dois anos de escolaridade.

Radiation as a Tool against Neurodegeneration-A Potential Treatment for Amyloidosis in the Central Nervous System.

Radiotherapy (RT) is a relatively safe and established treatment for cancer, where the goal is to kill tumoral cells with the lowest toxicity to healthy tissues. Using it for disorders involving cell loss is counterintuitive. However, ionizing radiation has a hormetic nature: it can have deleterious or beneficial effects depending on how it is applied. Current evidence indicates that radiation could be a promising treatment for neurodegenerative disorders involving protein misfolding and amyloidogenesis, such as Alzheimer's or Parkinson's diseases. Low-dose RT can trigger antioxidant, anti-inflammatory and tissue regeneration responses. RT has been used to treat peripheral amyloidosis, which is very similar to other neurodegenerative disorders from a molecular perspective. Ionizing radiation prevents amyloid formation and other hallmarks in cell cultures, animal models and pilot clinical trials. Although some hypotheses have been formulated, the mechanism of action of RT on systemic amyloid deposits is still unclear, and uncertainty remains regarding its impact in the central nervous system. However, new RT modalities such as low-dose RT, FLASH, proton therapy or nanoparticle-enhanced RT could increase biological effects while reducing toxicity. Current evidence indicates that the potential of RT to treat neurodegeneration should be further explored.

Radiotherapy setup displacements in breast cancer patients: 3D surface imaging experience.

AIM: In this study, we intend to compare two different setup procedures for female breast cancer patients. BACKGROUND: Imaging in radiotherapy provides a precise localization of the tumour, increasing the accuracy of the treatment delivery in breast cancer. MATERIALS AND METHODS: Twenty breast cancer patients who underwent whole breast radiotherapy (WBRT) were selected for this study. Patients were divided into two groups of ten. Group one (G1) was positioned by tattoos and then the patient positioning was adjusted with the aid of AlignRT (Vision RT, London, UK). In group two (G2), patients were positioned only by tattoos. For both groups, the first 15 fractions were analyzed, a daily kilovoltage (kV) cone beam computed tomography (CBCT) image was made and then the rotational and translational displacements and, posteriorly, the systematic (Σ) and random (σ) errors were analyzed. RESULTS: The comparison of CBCT displacements for the two groups showed a statistically significant difference in the translational left-right (LR) direction (ρ = 0.03), considering that the procedure with AlignRT system has smaller lateral displacements. The results of systematic (Σ) and random (σ) errors showed that for translational displacements the group positioned only by tattoos (G2) demonstrated higher values of errors when compared with the group positioned with the aid of AlignRT (G1). CONCLUSIONS: AlignRT could help the positioning of breast cancer patients; however, it should be used with another imaging method.

Evaluation of administered dose using portal images in craniospinal irradiation of pediatric patients.

This study aimed to assess the administered dose based on portal imaging in craniospinal pediatric irradiation by evaluating cases in which portal images did or did not account for the total administered dose. We also intended to calculate the mean increase in total administered dose. Data were collected from General University Hospital Gregorio Marañón; we evaluated the total dose administered, total dose planned, number of portal images per treatment and corresponding monitor units of two different groups: one in which the dose from portal images is deducted from the total administered dose (D), and another in which it was not (N). We used descriptive statistics to analyze the collected data, including the mean and respective standard deviation. We used the Shapiro-Wilk and Spearman rank correlation coefficient tests and estimated the linear regression coefficients. Patients in group D received a mean dose of 29.00 ± 10.28 cGy based on the verification portal images, a quantity that was deducted from the planned dose to match the total administered dose. Patients in group N received a mean dose of 41.50 ± 30.53 cGy, which was not deducted from the planned dose, evidencing a mean increase of 41.50 ± 30.55 cGy over the total administered dose. The acquisition of the set-up verification portal images, without their inclusion in the total administered dose, reflects an average increase in total dose for craniospinal irradiation of pediatric patients. Subtraction of the monitor units used to acquire the verification images is recommended.

Evaluating deviations in prostatectomy patients treated with IMRT.

AIM: To evaluate the deviations in prostatectomy patients treated with IMRT in order to calculate appropriate margins to create the PTV. BACKGROUND: Defining inappropriate margins can lead to underdosing in target volumes and also overdosing in healthy tissues, increasing morbidity. MATERIAL AND METHODS: 223 CBCT images used for alignment with the CT planning scan based on bony anatomy were analyzed in 12 patients treated with IMRT following prostatectomy. Shifts of CBCT images were recorded in three directions to calculate the required margin to create PTV. RESULTS AND DISCUSSION: The mean and standard deviation (SD) values in millimetres were -0.05 ± 1.35 in the LR direction, -0.03 ± 0.65 in the SI direction and -0.02 ± 2.05 the AP direction. The systematic error measured in the LR, SI and AP direction were 1.35 mm, 0.65 mm, and 2.05 mm with a random error of 2.07 mm; 1.45 mm and 3.16 mm, resulting in a PTV margin of 4.82 mm; 2.64 mm, and 7.33 mm, respectively. CONCLUSION: With IGRT we suggest a margin of 5 mm, 3 mm and 8 mm in the LR, SI and AP direction, respectively, to PTV1 and PTV2. Therefore, this study supports an anisotropic margin expansion to the PTV being the largest expansion in the AP direction and lower in SI.

Nature of phenolic compounds in coffee melanoidins.

Phenolic compounds are incorporated into coffee melanoidins during roasting mainly in condensed form (42-62 mmol/100 g) and also in ester-linked form (1.1-1.6 mmol/100 g), with incorporation levels depending on the green coffee chlorogenic acid content. The phenolic compounds are incorporated in different coffee melanoidin populations, but mainly in those soluble in 75% ethanol (82%), a significant correlation between the amount of phenolic compounds and the amount of protein and color characteristics of the different melanoidin populations being observed. The incorporation of phenolic compounds into coffee melanoidins is a significant pathway of chlorogenic acid degradation during roasting, representing 23% of the chlorogenic acids lost. These account for the nearly 26% of the material not accounted for by polysaccharides and proteins present in coffee melanodins. The cleavage mechanism and the efficiency of alkaline fusion used to release condensed phenolics from coffee melanoidins suggest that the phenolic compounds can be linked to the polymeric material by aryl-ether, stilbene type, and/or biphenyl linkages.

Dermolipectomia higiênica em infecção por micobactéria não tuberculosa: relato de caso / Hygienic dermolipectomy in infeccion by non-tuberculous mycobacteria: case report

Introdução: A incidência de infecção por micobactéria não tuberculosa está aumentando em todo o mundo. No Brasil, já tivemos dois grandes surtos dessa infecção após cirurgias plásticas. Isso tem chamado a atenção de cirurgiões quanto ao diagnóstico e ao tratamento da micobacteriose. Fisiopatologia: As estações de tratamento de água são os reservatórios das micobactérias. As mesmas acabam por contaminar equipamentos médicos. Após o contato do paciente com o material, este desenvolve a infecção. Tratamento: É realizado por meio do uso de antibióticos. Às vezes, a ressecção das lesões acelera o tratamento. Relato do caso: Relatamos o caso de um paciente ainda obeso, com abdome em avental após perda ponderal acentuada, e com múltiplas lesões por micobactéria disseminadas por todo o abdome. A fonte de infecção foi uma colecistectomia convencional. Como forma de ressecar todas as lesões macroscópicas do abdome, optamos por realizar uma dermolipectomia higiênica após marcação do abdome em âncora. Conclusão: A melhor maneira de nossos pacientes não adquirirem esse tipo de infecção é assegurarmos a higiene adequada de nosso material cirúrgico.

Introduction: The incidence of non tuberculous mycobacterial disease is increasing worldwide. In Brazil, we had two big outbreaks of this bacterial infeccion after plastic surgeries. This has drawn the attention of surgeons to the diagnosis and treatment of mycobacteriosis. Physiopatologhy: Water supplies are now recognized as a reservoir for mycobacterias. These bacterias end up contaminating medical equipment. After the contact of the patients with the material, they develop the infeccion. Treatment: Mycobacterial lesions are primarily treated using antimicrobial agents. However, removal of the lesion may speed resolution. Case report: We reported a case of a patient still obese, with massive hanging pannus after important weigtht loss and multiple injuries by mycobacteria spread throughout the abdomen. The source of infection was a conventional cholecystectomy. As a way to resect all macroscopic lesions of the abdomen, we choose to perform a hygienic dermolipectomy after marking in anchor. Conclusion: The best way of our patients not to acquire this type of infection is through the appropriate hygiene of our surgical material.