High-Fidelity Indirect Readout of Trapped-Ion Hyperfine Qubits.

We propose and demonstrate a protocol for high-fidelity indirect readout of trapped ion hyperfine qubits, where the state of a ^{9}Be^{+} qubit ion is mapped to a ^{25}Mg^{+} readout ion using laser-driven Raman transitions. By partitioning the ^{9}Be^{+} ground-state hyperfine manifold into two subspaces representing the two qubit states and choosing appropriate laser parameters, the protocol can be made robust to spontaneous photon scattering errors on the Raman transitions, enabling repetition for increased readout fidelity. We demonstrate combined readout and back-action errors for the two subspaces of 1.2_{-0.6}^{+1.1}×10^{-4} and 0_{-0}^{+1.9}×10^{-5} with 68% confidence while avoiding decoherence of spectator qubits due to stray resonant light that is inherent to direct fluorescence detection.

Resource-Efficient Dissipative Entanglement of Two Trapped-Ion Qubits.

We demonstrate a simplified method for dissipative generation of an entangled state of two trapped-ion qubits. Our implementation produces its target state faster and with higher fidelity than previous demonstrations of dissipative entanglement generation and eliminates the need for auxiliary ions. The entangled singlet state is generated in ∼7 ms with a fidelity of 0.949(4). The dominant source of infidelity is photon scattering. We discuss this error source and strategies for its mitigation.

Quantum Harmonic Oscillator Spectrum Analyzers.

Characterization and suppression of noise are essential for the control of harmonic oscillators in the quantum regime. We measure the noise spectrum of a quantum harmonic oscillator from low frequency to near the oscillator resonance by sensing its response to amplitude modulated periodic drives with a qubit. Using the motion of a trapped ion, we experimentally demonstrate two different implementations with combined sensitivity to noise from 500 Hz to 600 kHz. We apply our method to measure the intrinsic noise spectrum of an ion trap potential in a previously unaccessed frequency range.

Direct Kerr frequency comb atomic spectroscopy and stabilization.

Microresonator-based soliton frequency combs, microcombs, have recently emerged to offer low-noise, photonic-chip sources for applications, spanning from timekeeping to optical-frequency synthesis and ranging. Broad optical bandwidth, brightness, coherence, and frequency stability have made frequency combs important to directly probe atoms and molecules, especially in trace gas detection, multiphoton light-atom interactions, and spectroscopy in the extreme ultraviolet. Here, we explore direct microcomb atomic spectroscopy, using a cascaded, two-photon 1529-nm atomic transition in a rubidium micromachined cell. Fine and simultaneous repetition rate and carrier-envelope offset frequency control of the soliton enables direct sub-Doppler and hyperfine spectroscopy. Moreover, the entire set of microcomb modes are stabilized to this atomic transition, yielding absolute optical-frequency fluctuations at the kilohertz level over a few seconds and <1-MHz day-to-day accuracy. Our work demonstrates direct atomic spectroscopy with Kerr microcombs and provides an atomic-stabilized microcomb laser source, operating across the telecom band for sensing, dimensional metrology, and communication.

Subharmonic Entrainment of Kerr Breather Solitons.

We predict subharmonic entrainment of breather-soliton oscillations to a periodic perturbation at the round-trip time T_{R} in Kerr-nonlinear optical resonators; an integer ratio T_{b}/T_{R}=N≫1 results for breathing period T_{b}. Rigid entrainment is observed with intermediate finesse (F∼30-40) for N up to 20, and we propose a way to realize higher entrainment ratios at higher finesse. This nontrivial synchronization across the widely separated timescales of the photon lifetime and round-trip time points to a new direction for research in this field and may find application, for example, in the measurement of a pulse train repetition rate that is electronically inaccessible.

Dual-comb interferometry via repetition rate switching of a single frequency comb.

We experimentally demonstrate a versatile technique for performing dual-comb interferometry using a single frequency comb. By rapid switching of the repetition rate, the output pulse train can be delayed and heterodyned with itself to produce interferograms. The full speed and resolution of standard dual-comb interferometry is preserved while simultaneously offering a significant experimental simplification and cost savings. We show that this approach is particularly suited for absolute distance metrology due to an extension of the nonambiguity range as a result of the continuous repetition rate switching.

Cardiovascular Complications of Proteasome Inhibitors Used in Multiple Myeloma.

The use of proteasome inhibitors (PI) as targeted chemotherapeutics have significantly improved survival in patients with multiple myeloma (MM). However, rare and serious cardiovascular complications have occurred as a result of their use, most commonly congestive heart failure, hypertension, and arrhythmias. MM occurs in an aged population with many concurrent cardiovascular risk factors. The primary disease process also contributes to cardiovascular complications. Furthermore, many MM patients have prior exposure to cardiotoxic chemotherapy such as anthracyclines. Because of these occurrences, the identification, prevention, and management of cardiovascular complications is made increasingly difficult. Various clinical studies and case reports have documented cardiotoxicity among all 3 of the currently approved PIs, bortezomib, carfilzomib, and ixazomib. Carfilzomib has shown the highest rates of cardiotoxicity, whereas there is conflicting evidence regarding bortezomib's role in producing cardiotoxicity. However, various case reports have documented the existence of adverse cardiac effects. Higher frequencies of complications have also been seen in "real-life" populations with cardiovascular co-morbidities who were originally excluded from clinical studies. Ixazomib, the most recently approved PI, has also been proposed to cause cardiotoxicity, elucidating a possible class effect. PIs are thought to cause cardiotoxicity through the unfolded protein response, leading to apoptosis in cardiac myocytes. Apremilast and rutin have been used in an animal model to reverse this signaling. Standardized guidelines identifying patients at greatest risk, to prevent and manage complications, have not yet been developed. Efforts have been made to prioritize patients older than 60 years with anthracycline exposure, cardiovascular risk factors, or amyloidosis. Withholding medication, using slower-infusion times, limiting fluids and providing supportive therapy have been successful. Screening echocardiograms have not been proven effective.

Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology.

Microglia (MG), a heterogeneous population of phagocytic cells, play important roles in central nervous system (CNS) homeostasis and neural plasticity. Under steady-state conditions, MG maintain homeostasis by producing antiinflammatory cytokines and neurotrophic factors, support myelin production, and remove synapses and cellular debris, as well as participating in "cross-correction," a process that supplies neurons with key factors for executing autophagy-lysosomal function. As sentinels for the immune system, MG also detect "danger" signals (pathogenic or traumatic insult), become activated, produce proinflammatory cytokines, and recruit monocytes and dendritic cells to the site of damage through a breached blood-brain barrier or via brain lymphatics. Failure to effectively resolve MG activation can be problematic and can lead to chronic inflammation, a condition proposed to underlie CNS pathophysiology in heritable brain disorders and age-related neurodegenerative and cognitive decline. Here, we show that APOBEC1-mediated RNA editing occurs within MG and is key to maintaining their resting status. Like bone marrow-derived macrophages, RNA editing in MG leads to overall changes in the abundance of edited proteins that coordinate the function of multiple cellular pathways. Conversely, mice lacking the APOBEC1 editing function in MG display evidence of dysregulation, with progressive age-related signs of neurodegeneration, characterized by clustering of activated MG, aberrant myelination, increased inflammation, and lysosomal anomalies that culminate in behavioral and motor deficiencies. Collectively, our study identifies posttranscriptional modification by RNA editing as a critical regulatory mechanism of vital cellular functions that maintain overall brain health.

Analysis of orbital decay time for the classical hydrogen atom interacting with circularly polarized electromagnetic radiation.

Here we show that a wide range of states of phases and amplitudes exist for a circularly polarized (CP) plane wave to act on a classical hydrogen model to achieve infinite times of stability (i.e., no orbital decay due to radiation reaction effects). An analytic solution is first deduced to show this effect for circular orbits in the nonrelativistic approximation. We then use this analytic result to help provide insight into detailed simulation investigations of deviations from these idealistic conditions. By changing the phase of the CP wave, the time t(d) when orbital decay sets in can be made to vary enormously. The patterns of this behavior are examined here and analyzed in physical terms for the underlying but rather unintuitive reasons for these nonlinear effects. We speculate that most of these effects can be generalized to analogous elliptical orbital conditions with a specific infinite set of CP waves present. The paper ends by briefly considering multiple CP plane waves acting on the classical hydrogen atom in an initial circular orbital state, resulting in "jump-like" and "diffusion-like" orbital motions for this highly nonlinear system. These simple examples reveal the possibility of very rich and complex patterns that occur when a wide spectrum of radiation acts on this classical hydrogen system.