Looking the same, but remembering differently: Preserved eye-movement synchrony with age during movie watching.

Naturalistic stimuli (e.g., movies) provide the opportunity to study lifelike experiences in the lab. While young adults respond to these stimuli in a highly synchronized manner [as indexed by intersubject correlations (ISC) in their neural activity], older adults respond more idiosyncratically. Here, we examine whether eye-movement synchrony (eye-ISC) also declines with age during movie-watching and whether it relates to memory for the movie. Our results show no age-related decline in eye-ISC, suggesting that age differences in neural ISC are not caused by differences in viewing patterns. Both age groups recalled the same number of episodic details from the movie, but older adults recalled proportionally fewer episodic details due to their greater output of semantic and false information. In both age groups, higher eye-ISC related to a higher proportion of internal details and a lower proportion of false information being recalled. Finally, both older and younger adults showed better cued recall for cues taken from within the same event than those spanning an event boundary, further confirming that events are stored in long-term memory as discrete units with stronger associations within than across event boundaries. Taken together, these findings suggest that naturalistic stimuli drive perception in a similar way in younger and older adults, but age differences in neural synchrony further up the information processing stream may contribute to subtle differences in event memory. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

A centrality based multi-objective approach to disease gene association.

Disease Gene Association finds genes that are involved in the presentation of a given genetic disease. We present a hybrid approach which implements a multi-objective genetic algorithm, where input consists of centrality measures based on various relational biological evidence types merged into a complex network. Multiple objective settings and parameters are studied including the development of a new exchange methodology, safe dealer-based crossover. Successful results with respect to breast cancer and Parkinson's disease compared to previous techniques and popular known databases are shown. In addition, the newly developed methodology is also successfully applied to Alzheimer's disease, further demonstrating its flexibility. Across all three case studies the strongest results were produced by the shortest path-based measures stress and betweenness, either in a single objective parameter setting or when used in conjunction in a multi-objective environment. The new crossover technique achieved the best results when applied to Alzheimer's disease.