The Association Between Mindfulness Facets and Substance Use via Emotional Psychopathology and Coping Motives in Argentinian College Students.

Background: Prior studies suggest that lower levels of mindfulness contribute to the motivation of using alcohol to cope with distress. Research examining this possibility is scarce or limited to alcohol, but not marijuana, related outcomes. Objectives: We examined separate models (for alcohol and for marijuana) to determine the associations between trait mindfulness (describing, acting with awareness, non-judging, non-reactivity) and alcohol and marijuana outcomes (use indicators and negative consequences) via emotional psychopathology (i.e., a latent variable assessing symptoms of depression and anxiety) and alcohol/marijuana coping motives. Results: The final analytic sample consisted of 456 participants (Mean age = 22.96 ± 3.12 years; 66.2% women) for the alcohol model; and 232 participants (Mean age = 22.96 ± 3.01 years; 66.2% women) for the marijuana model. Two path models were conducted, such that indirect paths were examined for each trait mindfulness facet on alcohol/marijuana outcomes (e.g., describing → emotional psychopathology → alcohol coping motives → binge drinking frequency). Within the comprehensive alcohol model, describing, acting with awareness, non-judging and non-reactivity were associated with less binge drinking frequency and lower number of alcohol-related negative consequences via lower severity of emotional psychopathology symptoms and lower endorsement of drinking to cope motives. For the marijuana model, describing, acting with awareness, and non-judging of inner experience were associated with less marijuana quantity (grams) consumed and lower number of marijuana-related negative consequences via lower severity of emotional psychopathology symptoms and lower endorsement of marijuana coping motives. Conclusions: Prevention and intervention programs of alcohol and marijuana in Argentina may benefit from improving mindfulness skills and targeting emotional psychopathology and motives to use drugs, to prevent or reduce negative drug-related consequences.

Mitochondrial bioenergetics as a cell fate rheostat for responsive to Bcl-2 drugs: New cues for cancer chemotherapy.

Pro-survival BCL-2 proteins prevent the initiation of intrinsic apoptosis (mitochondria-dependent pathway) by inhibiting the pro-apoptotic proteins BAX and BAK, while BH3-only proteins promote apoptosis by blocking pro-survival BCL-2 proteins. Disruptions in this delicate balance contribute to cancer cell survival and chemoresistance. Recent advances in cancer therapeutics involve a new generation of drugs known as BH3-mimetics, which are small molecules designed to mimic the action of BH3-only proteins. Promising effects have been observed in patients with hematological and solid tumors undergoing treatment with these agents. However, the rapid emergence of mitochondria-dependent resistance to BH3-mimetics has been reported. This resistance involves increased mitochondrial respiration, altered mitophagy, and mitochondria with higher and tighter cristae. Conversely, mutations in isocitrate dehydrogenase 1 and 2, catalyzing R-2-hydroxyglutarate production, promote sensitivity to venetoclax. This evidence underscores the urgency for comprehensive studies on bioenergetics-based adaptive responses in both BH3 mimetics-sensitive and -resistant cancer cells. Ongoing clinical trials are evaluating BH3-mimetics in combination with standard chemotherapeutics. In this article, we discuss the role of mitochondrial bioenergetics in response to BH3-mimetics and explore potential therapeutic opportunities through metabolism-targeting strategies.

Genomic and Experimental Analysis of the Insecticidal Factors Secreted by the Entomopathogenic Fungus Beauveria pseudobassiana RGM 2184.

The entomopathogenic fungus Beauveria pseudobassiana strain RGM 2184 can reach a maximum efficacy of 80% against the quarantine pest Lobesia botrana in field assays. In this study, the RGM 2184 genome was sequenced, and genome mining analyses were performed to predict the factors involved in its insecticidal activity. Additionally, the metabolic profiling of the RMG 2184 culture's supernatants was analyzed by mass spectrometry, and the insecticidal activity from one of these extracts was evaluated in Galleria mellonella larvae. The genome analysis resulted in 114 genes encoding for extracellular enzymes, four biosynthetic gene clusters reported as producers of insecticidal and bactericidal factors (oosporein, beauvericin, desmethylbassianin, and beauveriolide), 20 toxins, and at least 40 undescribed potential biocontrol factors (polyketides and nonribosomal peptides). Comparative genomic analysis revealed that 65-95% of these genes are Beauveria genus-specific. Metabolic profiling of supernatant extracts from RGM 2184 cultures exhibited secondary metabolites such as beauveriolide, oosporein, inflatin C, and bassiatin. However, a number of detected metabolites still remain undescribed. The metabolite extract caused 79% mortality of Galleria mellonella larvae at 28 days. The results of this research lay the groundwork for the study of new insecticidal molecules.

Adaptación de una escala para evaluar contacto entre ciudadanos de distinta clase social del Gran Córdoba (Argentina)

Resumen: Introducción. La escala propuesta por Islam y Hewstone (1993) evalúa la frecuencia y la calidad del contacto entre distintos grupos. Aunque es una de las escalas más empleadas para evaluar el contacto intergrupal, a la fecha no hay investigaciones, según nuestro conocimiento, que hayan empleado dicha escala en muestras de Argentina ni en grupos que pertenezcan a distintas clases sociales. Objetivo. Adaptar la escala de contacto intergrupal propuesta por Islam y Hewstone (1993) en una muestra de personas de 18 a 65 años de distinta clase social, radicadas en el Gran Córdoba (Argentina). Método. Empleamos un muestreo no probabilístico de tipo autoelegido y participaron 442 personas. Llevamos a cabo la adaptación lingüística y cultural de los ítems de la escala original y elaboramos tres versiones idénticas de la escala en las cuales lo que varía es el grupo evaluado (clase alta, clase media, o clase baja). Resultados. Obtuvimos evidencias satisfactorias acerca de la validez estructural, convergente, discriminante y predictiva de la escala en todas sus versiones. Además, los resultados sobre la consistencia interna fueron adecuados. Discusión. La adaptación de la presente escala representa un aporte significativo al campo de conocimiento y evaluación del contacto intergrupal.

Abstract: Introduction. The scale proposed by Islam and Hewstone (1993) assesses the frequency and quality of contact between different groups. Although it is one of the most widely used scales to evaluate intergroup contact, to date there are no studies, to our best knowledge, that have used this scale in samples from Argentina or in groups belonging to different social classes. Objective. To adapt the intergroup contact scale proposed by Islam and Hewstone (1993) in a sample of people between 18 and 65 years old from different social classes, who live in the Gran Córdoba (Argentina). Method. We used a no-probabilistic sampling (self-selected) and 442 citizens participated. We carried out the linguistic and cultural adaptation of the items of the original scale and elaborated three identical versions of the scale in which what varies is the group evaluated (high, medium or low class). Results. We obtained satisfactory evidence about the structural, convergent, discriminant and predictive validity of the scale. In addition, the results about internal consistency were adequate. Discussion. The adaptation of this scale represents a significant contribution to the field of knowledge and evaluation of intergroup contact.

Resumo: Introdução. A escala proposta por Islam e Hewstone (1993) avalia a frequência e a qualidade do contato entre diferentes grupos. Embora seja uma das escalas mais utilizadas para avaliar o contato intergrupal, até o momento não há investigações, ao nosso conhecimento, que tenham utilizado esta escala em amostras da Argentina ou em grupos pertencentes a diferentes classes sociais. Objetivo. Adaptar a escala de contato intergrupal proposta por Islam e Hewstone (1993) em uma amostra de pessoas entre 18 e 65 anos de diferentes classes sociais, residentes na Grande Córdoba (Argentina). Método. Utilizamos uma amostra não probabilística auto-selecionada e 442 pessoas participaram. Realizamos a adaptação linguística e cultural dos itens da escala original e elaboramos três versões idênticas da escala em que o que varia é o grupo avaliado (classe alta, classe média ou classe baixa). Resultados. Obtivemos evidências satisfatórias sobre a validade estrutural, convergente, discriminante e preditiva da escala. Além disso, os resultados de consistência interna foram adequados. Discussão. A adaptação desta escala representa uma contribuição significativa para o campo do conhecimento e avaliação do contato intergrupal.

The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition and Effect on the Proliferation and Migration of Lung Cancer Cells.

Since Rhinella sp. toads produce bioactive substances, some species have been used in traditional medicine and magical practices by ancient cultures in Peru. During several decades, the Rhinella horribilis toad was confused with the invasive toad Rhinella marina, a species documented with extensive toxinological studies. In contrast, the chemical composition and biological effects of the parotoid gland secretions (PGS) remain still unknown for R. horribilis. In this work, we determine for the first time 55 compounds from the PGS of R. horribilis, which were identified using HPLC-MS/MS. The crude extract inhibited the proliferation of A549 cancer cells with IC50 values of 0.031 ± 0.007 and 0.015 ± 0.001 µg/mL at 24 and 48 h of exposure, respectively. Moreover, it inhibited the clonogenic capacity, increased ROS levels, and prevented the etoposide-induced apoptosis, suggesting that the effect of R. horribilis poison secretion was by cell cycle blocking before of G2/M-phase checkpoint. Fraction B was the most active and strongly inhibited cancer cell migration. Our results indicate that the PGS of R. horribilis are composed of alkaloids, bufadienolides, and argininyl diacids derivatives, inhibiting the proliferation and migration of A549 cells.

An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells.

Since cancer cells have different mitochondrial bioenergetic requirements than non-cancerous cells, therapeutic inhibition of its mitochondrial functionality continues to be an important target for anticancer drug discovery. In this study, a series of acylhydroquinones with different acyl-chain length, and their chlorinated derivatives, in the aromatic ring, synthesized by Fries rearrangement under microwave irradiation, were evaluated for their anticancer activity in two leukemia cell lines. Findings from the primary and secondary screening of the 18 acylhydroquinones, tested at 5 µM on acute promyelocytic leukemia HL-60 and acute lymphoblastic leukemia CEM cells lines, identified an acylchlorohydroquinone (12) with a highly selective anti-proliferative effect toward HL-60 cells. This compound induced S-phase arrest in the cell cycle progression of HL-60 cells with insignificant toxicity on leukemic CEM cells and non-cancerous Hs27 cells. In HL-60 leukemic cells, 12 triggered increased mitochondrial NADH oxidation, increased respiration in presence of oligomycin (state 4o), mitochondrial depolarization, and ROS production, suggesting an uncoupling of OXPHOS. This provoked a metabolic adaptation dependent on AMPK/ACC/autophagy axis, having the mitochondrial ß-oxidation a pro-survival role since the combination of 12 and etomoxir, a carnitine palmitoyl-transferase (CPT) inhibitor promoted extensive HL-60 cell death. Finally, 12-induced metabolic stress sensitized to HL-60 cells to cell death by the FDA-approved anti-leukemic drug ABT-199, a BH3 mimetic. Therefore, our results suggest that acylchlorohydroquinone is a promising scaffold in anti-promyelocytic leukemia drug research.

Explorando las relaciones entre el estrés y la situación económica en ciudadanos de Córdoba, Argentina / Exploring the relationships between stress and the economic situation in citizens from Córdoba, Argentina

Resumen El estrés afecta nuestra percepción del mundo y también nuestro comportamiento, pero parece no afectar a todos por igual, sino que esta influencia varía según factores tales como el estatus económico. A partir de eso, en este estudio analizamos las diferencias en los niveles de estrés percibido según el sexo y el estatus socioeconómico, y su relación con la percepción de la situación económica tanto de la familia como del país, en una muestra de ciudadanos de Córdoba, Argentina. La muestra comprendió 279 personas de 18 a 65 años (M = 36.61, DS = 13.97). Se utilizaron cuestionarios estructurados para evaluar las distintas variables de interés. Los resultados evidenciaron diferencias en los niveles de estrés percibido según el estatus económico, aunque la magnitud fue baja. A su vez, se observaron relaciones con la percepción de la situación económica, particularmente de la familia, con un tamaño del efecto de pequeño a moderado. Se subraya la necesidad de contar con nueva evidencia empírica sobre los determinantes y consecuencias del estrés.

Abstract Stress affects our perception of the world and our behavior, but it does not seem to affect everyone equally, instead that influence varies according to factors such as economic status. Taking this into account, in this study we analyze the differences in the levels of perceived stress according to sex and socioeconomic status, and its relationship with the perception of the economic situation of both the family and the country, in a sample of citizens from Córdoba Argentina. The sample comprised people from 18 to 65 years old (M = 36.61, DS = 13.97). Structured questionnaires were used to evaluate the different variables of interest. The results showed differences in perceived stress levels according to economic status, although the magnitude was low. In turn, relationships were observed with the perception of the economic situation, particularly of the family, with a small to moderate effect size. The need to have new empirical evidence on the determinants and consequences of stress is underlined.

Resección de fibroma en mucosa oral. Técnica del estrangulamiento / Resection of fibrous lesion in oral mucosa. Throttling technique

El fibroma traumático es considerado un crecimiento tumoral benigno que aparece en cualquier órgano, pero lo hace con mayor frecuencia en la cavidad oral. Se define como, una hiperplasia reactiva de tejido conectivo fibroso, siendo su factor etiológico el traumatismo o la irritación local. Se presenta generalmente asintomático, en sitios como, mucosa de revestimiento, bordes laterales de lengua y reborde alveolar de pacientes edéntulos. La lesión por lo general no se asocia con síntomas y se observa con mayor frecuencia en adultos, pero puede encontrarse en individuos de cualquier sexo y edad. En el presente artículo, se proponen una técnica para la extirpación quirúrgica de la lesión. Es un procedimiento simple en el que se busca disminuir el aporte vascular. No requiere mayor tiempo operatorio, además no implica un riesgo importante, ni complicaciones intra o extraoperatorias para los pacientes. Las recurrencias no son frecuentes, a menos que no se elimine el factor irritante.

The traumatic fibroma is considered a benign growth tumor that can appears in any organ, but it does most frequently in the oral cavity, and it is defined as a reactive hyperplasia of fibrous connective tissue, and it´s etiological factor is trauma or local irritation. It usually occurs asymptomatic in places like mucosal lining, tongue and side edges of alveolar ridge of edentulous patients. The injury usually is not associated with symptoms and is most often seen in adults, but can be found in individuals of any age and gender. In the present article, a new technique is proposed, which consist of surgical removal of the lesion. It is a simple procedure in which decreased vascular supply pressure is proposed and does not require more operating time, also does not involve a significant risk or complications for patients. Recurrences are rare, unless the irritant factor is eliminated.

Queratoquiste odontogénico: Reporte de un caso clínico, seguimiento a 10 años / Odontogenic keratocyst: a 10 year follow-up clinical case report

El queratoquiste odontogénico es una patología usualmente asociada con otros quistes como el dentígero, radicular y residual que puede contener células queratinizadas; sin embargo su diferencia radica en su aspecto histológico. Predomina en pacientes entre la segunda y tercera década de vida, con predilección por el sexo masculino. La literatura reporta que el queratoquiste se presenta con mayor frecuencia en la mandíbula casi en una proporción 2:1 afectando el cuerpo y la rama mas a menudo; en el maxilar superior en la zona de molares tiene mayor incidencia. El queratoquiste odontogénico se puede diagnosticar mediante examen clínico y radiográfico, sin embargo el diagnóstico definitivo debe confirmarse con el estudio microscópico de la lesión. Autores dan gran responsabilidad a los residuos de lamina dental en la mandíbula y el maxilar, también se ha discutido su origen por células básales del epitelio bucal superficial. Por otro lado, se trata de una patología de gran recurrencia benigna pero agresiva. Se presenta un caso clínico de queratoquiste odontogénico que compromete rama y cuerpo mandibular derecho en una paciente de 74 años de edad a la cual se realizó marsupialización, curetaje y enucleación de la lesión, el seguimiento realizado fue por 10 años. A pesar de que hubo presencia de recidiva, el resultado final y el contorno facial de la paciente fueron muy buenos.

The odontogenic keratocyst is a pathology usually associated with other cysts such as dentigerous, root and residual that may contain keratinized cells, but their difference lies in their histological appearance. It predominates in patients between the second and third decades of life, with a predilection for males. The literature reports that the keratocyst occurs most frequently in the jaw almost 2:1. Affecting more often the body and the rooms, the molar area is more prevalent. The odontogenic keratocyst can be diagnosed by clinical and radiographic examination; however a definitive diagnosis should be confirmed by microscopic examination. The authors give greater responsibility to the dental lamina residues, in the mandible and maxilla; it also discusses its origin by oral epithelial basal cell surface. Furthermore, it is a high recurrent benign pathology but aggressive. We present a case of odontogenic keratocyst in the right mandibular body and ramus, in a female patient of 74 years of age which was performed marsupialization, enucleation and curettage of the lesion. The monitoring was conducted for 10 years. Although recurrence were present, the final result and the patient's facial contours were very good.

Evaluación de tratamiento con artroplastia y eminectomía endesarreglos internos de la articulación temporomandibular (ATM) / A clinical evaluation of arthrotomy and eminectomy for internal derangement of temporomandibular joint (TMJ)

Introducción y Objetivo: El tratamiento de los desarreglos internos de la articulación temporomandibular ha tenido múltiples enfoques y se ha realizado de diversas maneras. La artrotomíade la articulación es considerada como última alternativa para casos renuentes al tratamiento conservador, sin embargo no ha estado exenta de controversia por los riesgos que presenta para el paciente, las complicaciones que eventualmente se pueden presentar y por los resultados que se pueden obtener a largo plazo. El objetivo es medir el éxito del procedimiento quirúrgico (artroplastia y eminectomía) en pacientes con desarreglos internos de la articulación temporomandibular (ATM). Materiales y Métodos: Se trata de un estudio clínico descriptivo retrospectivo con 20 pacientes que evaluó apertura máxima, ruidos y dolor articular. El dolor se evaluó con escala visual análoga; asimismo, valoró la satisfacción general de los pacientes que habían sido sometidos a cirugía de ATM. Resultados: Se encontró disminución significativa del dolor en 70% de los pacientes; los ruidos articulares persistieron en el 60% de los casos y el 15% mejoró en cuanto al ruido; 65% de los pacientes tuvieron apertura normal y hubo satisfacción del 90%. Conclusión: La cirugía de ATM con Artroplastia y eminectomía mejoran el dolor y disfunción de ATM en la población estudiada.

Introduction and Objetive: The treatment of the internal disorders of the temporomandibular joint has had multiple approaches and it has been made of diverse ways. The surgery of the joint is considered like last alternative for reluctant cases to the preservative treatment, nevertheless it does not have been free of controversy by the risks that displays for the patient, the complications which they are possible to be presented and by the results that can be obtained in the long term. The objective was to assess the success of surgical procedure (meniscal plication and eminectomy) in patients with internal derangement of the temporomandibular joint (TMJ). Materials and Methods: Twenty patients in a retrospective clinical study design. The maximal opening, noise/clicking, and joint pain was recorded preoperatively. Completed visual analogue scales of pain at the time of followup and the patient satisfaction were evaluated. Results: Decrease in TMJ pain after surgery was reported by 70% of the patients. Joint sounds persisted in a 60%, 15% improve in noise/clicking. Postoperative findings relating to open mouth showed 65% of the patients with normal opening.The patient satisfaction with this TMJ surgery was 90%. Conclusion: TMJ meniscal placation and eminectomy improve pain and dysfunction after surgery enhancing quality of life.

Caracterización de pacientes tratados por Cirugía Maxilofacialen la Clínica CES 2005-2007 / Characterization of patients treated at CES Clinic by the maxillofacial service

Introducción y Objetivo: La cirugía maxilofacial se ocupa de la prevención, estudio, diagnóstico, tratamiento quirúrgico y medicamentoso de las patologías que afectan la cavidad bucal y la cara, así como las estructuras cervicales relacionadas. El presente trabajo se orienta a evaluar las principales causas por las que se realiza cirugía maxilofacial, los diferentes tipos de patologías, la edad, el género, los días de estancia y las complicaciones que se presentaron en los pacientes de cirugía maxilofacial de la clínica CES. Materiales y Métodos: Se realizó un estudio descriptivo, transversal, retrospectivo basado en la información tomada de historias clínicas de 648 pacientes intervenidos por cirugía maxilofacial en la clínica CES entre los años 2005 a 2007. Resultados: El tipo de atención que más se presentó fue particular 52.6%, el tipo de cirugía más frecuente fue electiva 90%, las causas más comunes de los traumas fueron accidentes de tránsito y lesiones por caídas, la localización más frecuente de las fracturas fue el tercio inferior y la zona más afectada fue el ángulo mandibular, el procedimiento quirúrgico que predominó fue la cirugía ortognática 55%, requirieron fijación intermaxilar el 30.7%. El 50% de los pacientes fueron hospitalizados y el 0.92% presentó alguna complicación. Conclusiones: La mayoría de las cirugías realizadas fueron electivas, particulares y ortognáticas, predominando la población adulta joven de sexo femenino, la causa principal de los traumas fueron accidentes de tránsito y lesiones por caídas, la mitad de los pacientes requirió hospitalización y el promedio fue un día.

Introduction and Objective: Maxillofacial surgery deals with the prevention, study, diagnosis and surgical treatment of disorders affecting the oral cavity and face, neck and related structures. The purpose was to assess the main causes for the performance of that surgery, different types of diseases, age, gender, days of hospitalization, and complications that were presented at the CES clinic in the area of maxillofacial surgery. Materials and Methods: A descriptive, cross-sectional, retrospective study was performed. The information for analysis was taken from medical records of 648 patients operated by maxillofacial surgery at the CES clinic between 2005 and 2007. Results: The type of treatment most prevalent was private 52.6%, the most common surgery was elective 90%, the most common causes of trauma were from traffic accidents and injuries from falls; the most common site of fractures were the facial lower third and the most affected area was the mandibular angle, the predominant surgical procedure was orthognathic surgery 55%, requiring intermaxillar fixation 30.7%. The 50% of patients were hospitalized and only 0.92% had a complication. Conclusions: The majority of surgeries performed were elective, private and orthognathic, mainly of young female adults, the main cause of trauma were traffic accidents and injuries from falls, half of the patients required hospitalization with one day of average.

Retrospective serological survey of Porcine circovirus-2 infection in Mexico.

Postweaning multisystemic wasting syndrome (PMWS) is considered a multifactorial emerging disease of which Porcine circovirus-2 (PCV-2) is the necessary infectious cause. However, retrospective studies have shown that PMWS is not a new disease and that PCV-2 has been circulating in pig farms for years. Most of these studies were performed in Europe and Asia; only a few were performed in North or South America. A PCV-2 retrospective serological survey was carried out with 659 serum samples collected from pigs in Mexico between 1972 and 2000. Serological analyses were performed with an immunoperoxidase monolayer assay (IPMA). The overall prevalence of PCV-2 antibodies was 59% (387/659); the prevalence was 27% (24/90) for the period from 1972-1979; 44% (74/169) from 1980-1989, and 72% (289/400) from 1990-2000. Antibodies to PCV-2 were detected in at least 1 pig from all tested years since 1973. This study shows evidence of enzootic PCV-2 infection in Mexico for many years before the first description of PMWS in the country (in 2001), further supporting results obtained in other parts of the world. To date, this study provides the earliest evidence of PCV-2 infection in the North and South American continents.

Toxina botulínica para el manejo de pacientes con bruxismo / Botulinic toxin in the management of patients with bruxism

Se pretendió evaluar clínicamente la eficacia de la toxina botulínica tipo A-Botox – para el tratamiento de pacientes con bruxismo, evaluando 21 pacientes de ambos sexos entre 21 y 45 años de edad con bruxismo, que cumplieron con los criterios de inclusión. La toxina fue diluida en concentraciones de 5 U en 1 ml de suero fisiológico al 0,9 por ciento, se distribuyo en 10 sitios de infiltración total (5 sitios por cada lado). La piel fue desinfectada con algodón impregnado en alcohol. Se inyectaron 5 U de Botox en cada punto seleccionado en el Masetero y en el temporal, los cuales se marcaron previamente a la aplicación del medicamento. Se realizo un examen inicial y una remisión a los tres meses y a los seis meses para evaluar el dolor mediante una escala visual análoga (EVA) la presencia del dolor a la palpación en músculos masticatorios. Seis (6) hombres y las 15 mujeres con edad promedio de 29.±6.6 años mostraron una disminución de dolor de 5 puntos en la escala visual análoga en los tres primeros meses y de dos puntos a los seis meses luego de la aplicación de la tóxina. El 66.6 por ciento de los pacientes relatar tener bruxismo en menor medida mientras que el 33.3 por ciento relata no tener cambios en la intensidad del bruxismo tanto a los tres como a los seis meses. Solamente se presentó como efecto adverso, disminución en la salivación, tanto a los tres como a los seis meses en un solo paciente. La aplicación de toxina botulínica constituyen una alternativa terapéutica innovadora, segura y efectiva para el tratamiento del dolor en los músculos de la masticación, disminuye la intensidad del bruxismo, presenta pocos efectos adversos transitorios. El efecto benéfico de la toxina para el manejo del dolor muscular es más notorio a los tres que a los seis meses...

Programa de abordagem interdisciplinar no tratamento do transtorno de personalidade borderline: relato da experiência no ambulatório Melanie Klein do Hospital Psiquiátrico São Pedro / Program for an interdisciplinary approach in the treatment of borderline personality disorder: report on the experience at the Melanie Klein out-patient clinic at Hospital Psiquiátrico São Pedro

INTRODUÇÃO: Os transtornos de personalidade são uma classe diagnóstica em Psiquiatria cujo tratamento não está ainda claramente definido. Devido ao grande número de alterações que o transtorno de personalidade borderline ocasiona na vida de seus portadores, propomos um atendimento interdisciplinar integrado. Esta proposta organiza-se em quatro eixos: psicoterapia individual de orientação analítica, grupoterapia de orientação analítica, psicofarmacoterapia e intervenções sociais. METODOLOGIA: Este estudo baseia-se na descrição da experiência obtida pelos autores na implantação de um Programa de Abordagem Interdisciplinar no Tratamento do Transtorno de Personalidade Borderline, utilizando como exemplo dois relatos de caso sucintos, a respeito de duas pacientes com transtorno de personalidade borderline. Foram avaliados critérios qualitativos para descrever a melhora obtida pelas pacientes através do Programa (relacionamento interpessoal, interesses e atividades ocupacionais e de lazer, autonomia) e quantitativos (número de internações, tentativas de suicídio, procura por serviços de emergência). RESULTADOS E DISCUSSÃO: As intervenções sociais mostraram-se eficazes ao incrementar as terapêuticas já tradicionalmente colocadas. Houve melhoras relacionadas aos critérios acima colocados. CONCLUSÃO: Os resultados encontrados alertam-nos para a necessidade de observarmos os pacientes em seus diversos contextos, de forma a apresentar intervenções que dêem conta dessas múltiplas dimensões.

Cirugía ortognática y complicaciones anestésicas postoperatorias. Clínica CES Prado 1998 – 2001 / Postoperative anesthetic complications in orthognathic surgery patients at CES Clinic between 1998-2001

El propósito de esta investigacion fue cuantificar y analizar la información quirúrgica y anestésica hallada en las historias clínicas de 206 pacientes, sometidos a cirugía ortognática bajo anestesia general, en la Clínica CES Prado entre 1998 y 2001, se recolectaron datos personales, como edad, sexo, año, tipo y duración de la cirugía, técnica anestésica utilizada para el procedimiento con su respectivo tiempo de duración, presión arterial, frecuencia cardiaca y complicaciones postoperatorias mas comunes. Para el análisis de la información se utilizó el programa Epinfo 6.04. Se encontró que el índice de complicaciones post operatorias fue muy bajo, siendo mas frecuente las náuseas, presente en 5 pacientes de los 206analizados en el vómito en solo un caso. La cirugía ortognática mas frecuente realizada fue la osteotomía sagital de retrocesos de la rama mandibular, en 65 pacientes y la técnica anestésica más utilizada fue la mixta en 108 casos de los 206...

Cuatro dientes supernumerarios múltiples. Reporte de caso / Case report of patient with four supernumerary teeth

La presencia de dientes supernumerarios en un paciente no es tan infrecuente y ocurre usualmente en el área de la premaxila. Sin embargo, es muy rara la presencia de dientes supernumerarios en un mismo individuo. Se presenta el caso de un paciente con 4 dientes supernumerarios en 3 cuadrantes...

Láser en odontología / Use of laser in Dentistry

La tecnología láser ha tenido aplicación en el área de la salud desde hace más de 40 años y en odontología lleva 12 años luego de ser aprobado su uso clínico por la FDA; sin embargo la técnica, los equipos utilizados y su aplicación clínica no están muy difundidos en el medio colombiano. El presente articulo pretende dar una información básica del sistema como opera el rayo láser, los dientes tipos de equipos láser utilizados en odontología y sus principales aplicaciones clínicas; de tal manera que el lector pueda tener una aproximación...