RESUMEN
AIM: To investigate hCG on the expression of epidermal growth factor (EGF) in renal tissues. METHODS: 20 male SD rats weighed 300 - 350 g were injected hCG 200 IU/d for 7 days, and 20 male rats were injected sa-line at equal volume as a control. Kidney tissues were per-formed with immunohistochemical staining to evaluate the distribution of EGF and quantitative PCR (Q-PCR) was used to evaluate the EGF mRNA. RESULTS: Immunohistochemtry showed that the positive rate of EGF in experimental group was significantly higher than that in control group(P<0.01), but Q-PCR results showed no significant difference between two groups ( P > 0. 05). CONCLUSION: hCG increased the concentration of EGF by maturing pre-pro-EGF not expressing EGF from de novo synthesis.
