1.
J Org Chem
; 79(20): 9531-45, 2014 Oct 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25285791
RESUMEN
A detailed account is given describing the approaches used toward the total synthesis of aliskiren. In particular, ring-closing metathesis with the Hoveyda-Grubbs catalyst accelerates the formation of a 9-membered lactone from an (R)-ester. The diastereomeric (S)-ester leads to the formation of dimeric dilactones, which were characterized by X-ray analysis and chemical conversions.