1.
Bioorg Med Chem Lett
; 20(15): 4491-5, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20584610
RESUMEN
A novel series of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles has been synthesized. The ability of these compounds to act as antagonists of the androgen receptor was investigated and several were found to have potent activity in vitro and in vivo.