1.
Bioorg Med Chem Lett
; 15(15): 3524-7, 2005 Aug 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15990301
RESUMEN
The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the beta-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.