Asunto(s)
Enfermedades Placentarias , Vasculitis , Embarazo , Femenino , Humanos , Linfocitos T , Placenta , Corion , Vasculitis/diagnósticoRESUMEN
Fibrin-associated diffuse large B-cell lymphoma (fibrin-associated DLBCL) is a very rare subtype of Epstein-Barr virus (EBV)-associated DLBCL that usually develops within fibrin-rich lesions such as cardiac myxoma, chronic hematoma, thrombus, pseudocysts or cysts, prosthetic devices or breast implants. The pathogenesis as well as the clinicopathologic features of this usually indolent lymphoproliferative disorder, which are based on the analysis of a relatively limited number of cases, are still poorly known. Herein, we report a case of fibrin-associated DLBCL that was incidentally found within a multinodular goiter, a location not yet reported to our knowledge. Our findings not only illustrate further the specific nature of this peculiar lymphoproliferative disorder but also allow some interesting comments on its pathogenesis.
Asunto(s)
Infecciones por Virus de Epstein-Barr , Bocio , Linfoma de Células B Grandes Difuso , Infecciones por Virus de Epstein-Barr/complicaciones , Infecciones por Virus de Epstein-Barr/diagnóstico , Infecciones por Virus de Epstein-Barr/patología , Fibrina , Herpesvirus Humano 4 , Humanos , Linfoma de Células B Grandes Difuso/patologíaAsunto(s)
Canal Anal , Condiloma Acuminado/diagnóstico , Sífilis Cutánea/diagnóstico , Sífilis/diagnóstico , Treponema pallidum/aislamiento & purificación , Adulto , Canal Anal/microbiología , Canal Anal/patología , Canal Anal/cirugía , Diagnóstico Diferencial , Humanos , Masculino , Valor Predictivo de las Pruebas , Sífilis/microbiología , Sífilis/patología , Sífilis/cirugía , Sífilis Cutánea/microbiología , Sífilis Cutánea/patología , Sífilis Cutánea/cirugíaRESUMEN
According to the literature, serrated lesions and polyps of the appendix are extremely rare in children or teenagers. Herein, we present the pathologic and molecular features of a sessile serrated lesion (SSL) that was incidentally found in the appendix of a teenage girl. Our findings not only illustrate that appendiceal SSL may occur in young patients such as teenagers but also confirm further that BRAF V600E mutation may be found in a subset of these neoplastic lesions.
Asunto(s)
Apéndice/patología , Enfermedades del Ciego/patología , Proteínas Proto-Oncogénicas B-raf/genética , Adolescente , Enfermedades del Ciego/diagnóstico , Enfermedades del Ciego/genética , Femenino , Marcadores Genéticos , Humanos , Hallazgos Incidentales , Mutación PuntualRESUMEN
Natural killer (NK)-cell enteropathy (NKCE) and lymphomatoid gastropathy (LG) are closely related lymphoproliferative disorders (LPDs) composed of mature and Epstein-Barr virus (EBV)-negative NK-cells. Although these uncommon and indolent lymphoid proliferations mostly arise within the gastrointestinal (GI) tract as their designations implies, a few cases have been reported outside the GI tract. We hereby describe a unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis. The histologic, phenotypic, and molecular features of this NK-cell proliferation, which were very similar if not identical to those previously reported in NKCE or LG, suggest that similar indolent EBV-negative NK-cell LPDs may also occasionally involve lymph nodes.
Asunto(s)
Células Asesinas Naturales/patología , Ganglios Linfáticos/patología , Linfoma/patología , Trastornos Linfoproliferativos/patología , Adulto , Infecciones por Virus de Epstein-Barr/virología , Enfermedades Gastrointestinales/patología , Tracto Gastrointestinal/patología , Humanos , Enfermedades Intestinales/diagnóstico , Enfermedades Intestinales/patología , Linfoma/diagnóstico , Trastornos Linfoproliferativos/diagnóstico , Trastornos Linfoproliferativos/virología , MasculinoRESUMEN
We report a case of benign lymphoplasmacytic plaque (LPP) in a child. These asymptomatic erythematous papulonodular lesions are an emerging clinicopathological entity. Herein, we describe a previously unreported site for LPP lesions, namely, the volar wrist and the distal ipsilateral palm.
Asunto(s)
Seudolinfoma/diagnóstico , Seudolinfoma/terapia , Enfermedades de la Piel/diagnóstico , Enfermedades de la Piel/terapia , Preescolar , Humanos , Masculino , Seudolinfoma/etiología , Enfermedades de la Piel/etiologíaAsunto(s)
Dolor Abdominal/etiología , Sarcoma de Células Dendríticas Foliculares/complicaciones , Infecciones por Virus de Epstein-Barr/complicaciones , Granuloma de Células Plasmáticas/complicaciones , Anciano , Sarcoma de Células Dendríticas Foliculares/diagnóstico por imagen , Sarcoma de Células Dendríticas Foliculares/patología , Infecciones por Virus de Epstein-Barr/diagnóstico , Femenino , Granuloma de Células Plasmáticas/diagnóstico por imagen , Granuloma de Células Plasmáticas/patología , Humanos , Tomografía Computarizada por Rayos XRESUMEN
BACKGROUND: Chromosome abnormalities are important prognostic factors in myeloma allowing risk stratification of patients. Different techniques are available for their detection including cytogenetics, Fluorescent In Situ Hybridisation (FISH) and array Competitive Genomic Hybridisation (CGH). This study aimed to assess the validity and usefulness of each technique in a diagnostic setting. METHODS: 112 myeloma cases were analysed by whole bone marrow cytogenetics and by FISH and array CGH performed on purified plasma cell populations. RESULTS: Clonal abnormalities were identified in 30% of cases by cytogenetics and 97% by FISH and array CGH. By combining array and FISH results abnormalities were detected in 99% of cases and, if cytogenetic analysis was also considered, abnormalities were detected in 100% of cases. CONCLUSIONS: Cytogenetic analysis is of limited value in myeloma. Array CGH and FISH are highly specific tests allowing the identification of aberrations in virtually all cases. The two techniques are complementary and need to be combined in order to provide a comprehensive analysis of all clinically relevant aberrations in myeloma.
Asunto(s)
Biomarcadores de Tumor/genética , Aberraciones Cromosómicas , Cromosomas Humanos , Hibridación Genómica Comparativa , Análisis Citogenético , Perfilación de la Expresión Génica/métodos , Hibridación Fluorescente in Situ , Mieloma Múltiple/genética , Variaciones en el Número de Copia de ADN , Predisposición Genética a la Enfermedad , Humanos , Mieloma Múltiple/patología , Fenotipo , Ploidias , Valor Predictivo de las Pruebas , Translocación GenéticaRESUMEN
Plasmacytoid dendritic cells (PDC) belong to a subtype of dendritic cells that are normally absent in healthy skin. In some inflammatory diseases of the skin, especially lupus erythematosus (LE), these cells are occasionally recruited in great amounts, which can be used as a helpful clue for diagnosis. Rarely, PDC may also accumulate in the skin of patients with myeloid leukemia, a yet poorly known condition currently called 'tumor-forming PDC associated with myeloid neoplasms'. In this study, we describe a patient with unsuspected chronic myelomonocytic leukemia who developed cutaneous lesions characterized by a dermal infiltrate rich in PDC. Similarly to LE, such neoplastic PDC were accompanied by interface dermatitis-like changes, but displayed an aberrant phenotype and shared the same chromosomal abnormality with the leukemic cells identified in the bone marrow, thus revealing the neoplastic nature of the process. This observation illustrates that tumor-forming PDC associated with myeloid neoplasms may microscopically mimic LE in some patients. Accordingly, a hematologic workup is recommended in any skin lesion featuring excessive numbers of PDC, even if morphological alterations suggestive of interface dermatitis are found.
Asunto(s)
Células Dendríticas , Dermis , Leucemia Mieloide , Lupus Eritematoso Cutáneo , Células Plasmáticas , Neoplasias Cutáneas , Células Dendríticas/metabolismo , Células Dendríticas/patología , Dermis/metabolismo , Dermis/patología , Humanos , Leucemia Mieloide/metabolismo , Leucemia Mieloide/patología , Lupus Eritematoso Cutáneo/metabolismo , Lupus Eritematoso Cutáneo/patología , Masculino , Persona de Mediana Edad , Células Plasmáticas/metabolismo , Células Plasmáticas/patología , Neoplasias Cutáneas/metabolismo , Neoplasias Cutáneas/patologíaAsunto(s)
Cistoadenoma/patología , Quiste Folicular/patología , Folículo Piloso/patología , Neoplasias de las Glándulas Sebáceas/patología , Glándulas Sebáceas/patología , Siringoma/patología , Biomarcadores de Tumor/análisis , Biopsia , Diferenciación Celular , Cistoadenoma/química , Cistoadenoma/cirugía , Quiste Folicular/química , Quiste Folicular/cirugía , Folículo Piloso/química , Folículo Piloso/cirugía , Humanos , Inmunohistoquímica , Queratina-17/análisis , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Neoplasias de las Glándulas Sebáceas/química , Neoplasias de las Glándulas Sebáceas/cirugía , Glándulas Sebáceas/química , Glándulas Sebáceas/cirugía , Siringoma/química , Siringoma/cirugíaRESUMEN
A cutaneous infiltrate composed of plasmacytoid dendritic cells may occasionally occur in a patient suffering from a myeloid neoplasm. To date, the clinical and pathological features associated with this event remains poorly characterized. Herein, we report a patient with acute myeloid leukemia who developed pruritic papules or erythematous plaques scattered on the skin. Microscopic examination showed a dermal infiltrate rich in plasmacytoid dendritic cells expressing CD4, CD43, CD68, granzyme B, CD123, CD303 [blood dendritic cell antigen 2 (BDCA-2)], CD2-associated protein (CD2AP) and T-cell leukemia/lymphoma oncogene 1 (TCL1). Our observation illustrates further that cutaneous lesions associated with some myeloid neoplasms, especially those featuring a monocytic component, may be composed of plasmacytoid dendritic cells. Because of differences in clinical, pathological and genetic features, this rare condition should be distinguished from blastic plasmacytoid dendritic cell neoplasm.
Asunto(s)
Células Dendríticas/patología , Leucemia Mieloide Aguda/diagnóstico , Células Plasmáticas/patología , Plasmacitoma/diagnóstico , Neoplasias Cutáneas/diagnóstico , Anciano , Biomarcadores de Tumor/metabolismo , Células Dendríticas/metabolismo , Dermis/metabolismo , Dermis/patología , Diagnóstico Diferencial , Humanos , Leucemia Mieloide Aguda/metabolismo , Masculino , Células Plasmáticas/metabolismo , Plasmacitoma/metabolismo , Neoplasias Cutáneas/metabolismoRESUMEN
Secondary localization of chronic lymphocytic leukemia (CLL) in breast is rare, while concurrent invasive ductal carcinoma and CLL manifesting as a collision tumor in breast is extremely rare. The observation of a CLL infiltration closely associated with a distinct breast neoplasm with the absence of any other localization for the leukemia is an indisputable argument for a relationship between the two diseases. The presence of both tumors is not simply due to chance. This association (CLL and carcinoma) has also been described in other organs. Hereafter, we report a second case of an 80 year-old woman in whom a leukemic infiltrate was confined to the region immediately surrounding poorly differentiated primary breast carcinoma, and we will discuss the association between CLL and carcinoma.
Asunto(s)
Neoplasias de la Mama/patología , Carcinoma Ductal de Mama/patología , Leucemia Linfocítica Crónica de Células B/patología , Recurrencia Local de Neoplasia/patología , Neoplasias Primarias Secundarias/patología , Anciano de 80 o más Años , Mama/patología , Diagnóstico Diferencial , Femenino , Humanos , Infiltración Leucémica/patologíaAsunto(s)
Médula Ósea/patología , Enfermedades Mielodisplásicas-Mieloproliferativas/diagnóstico , Bazo/patología , Translocación Genética , Autoantígenos/genética , Proteínas de Ciclo Celular/genética , Cromosomas Humanos Par 8 , Cromosomas Humanos Par 9 , Humanos , Janus Quinasa 2/genética , Masculino , Persona de Mediana Edad , Enfermedades Mielodisplásicas-Mieloproliferativas/genéticaAsunto(s)
Balanitis Xerótica Obliterante/patología , Linfangiectasia/patología , Liquen Escleroso Vulvar/patología , Balanitis Xerótica Obliterante/complicaciones , Femenino , Humanos , Linfangiectasia/etiología , Masculino , Persona de Mediana Edad , Liquen Escleroso Vulvar/complicaciones , Adulto JovenAsunto(s)
Hiperplasia Angiolinfoide con Eosinofilia/inmunología , Hiperplasia Angiolinfoide con Eosinofilia/patología , Células Dendríticas/inmunología , Hiperplasia Angiolinfoide con Eosinofilia/metabolismo , Antígenos CD/metabolismo , Células Dendríticas/metabolismo , Humanos , Inmunofenotipificación , Masculino , Persona de Mediana EdadRESUMEN
Alimentary tract duplications are rare congenital malformations that occur most commonly in the jejunoileal part of the gastrointestinal tract. Management of this pathologic condition is usually drawn up. We report a case of descending colonic communicating duplication in which clinical presentation and anatomopathologic results were unexpected. A slightly echogenic abdominal mass reaching 72 x 36 mm in the left flank was diagnosed in a female fetus during the third trimester ultrasound examination. At birth, volume of the mass rapidly evolved, and despite no intestinal obstruction was observed by compression of the adjacent gastrointestinal tract, abdomen was distended. Abdominal plain film showed a large air collection, and the barium enema demonstrated a slight leak of contrast in the aerated mass, suggesting a communication with the sigmoid colon. No other abnormalities were seen. The patient underwent surgery in emergency. The mass was then totally excised through an antimesenteric resection of the tubular tract joining cystic mass and sigmoid colon. A lateral suture of the colon was subsequently performed. The wall of the duplication is usually composed of a smooth muscle layer covered by an epithelium, mostly of intestinal type. Herein, we describe a descending colonic duplication completely lined with nonkeratinizing squamous epithelium. Therefore, the association of a colonic mucosa (of endodermic origin) and a squamous epithelium (derived from the ectoderm) in our case is an interesting finding and is not explained by the various theories. Furthermore, the clinical characteristics, diagnosis, and treatment of intestinal duplications are discussed with regard to literature.