Predicting Body Mass Index From Structural MRI Brain Images Using a Deep Convolutional Neural Network.

In recent years, deep learning (DL) has become more widespread in the fields of cognitive and clinical neuroimaging. Using deep neural network models to process neuroimaging data is an efficient method to classify brain disorders and identify individuals who are at increased risk of age-related cognitive decline and neurodegenerative disease. Here we investigated, for the first time, whether structural brain imaging and DL can be used for predicting a physical trait that is of significant clinical relevance-the body mass index (BMI) of the individual. We show that individual BMI can be accurately predicted using a deep convolutional neural network (CNN) and a single structural magnetic resonance imaging (MRI) brain scan along with information about age and sex. Localization maps computed for the CNN highlighted several brain structures that strongly contributed to BMI prediction, including the caudate nucleus and the amygdala. Comparison to the results obtained via a standard automatic brain segmentation method revealed that the CNN-based visualization approach yielded complementary evidence regarding the relationship between brain structure and BMI. Taken together, our results imply that predicting BMI from structural brain scans using DL represents a promising approach to investigate the relationship between brain morphological variability and individual differences in body weight and provide a new scope for future investigations regarding the potential clinical utility of brain-predicted BMI.

Transfer learning improves resting-state functional connectivity pattern analysis using convolutional neural networks.

Background: Deep learning is gaining importance in the prediction of cognitive states and brain pathology based on neuroimaging data. Including multiple hidden layers in artificial neural networks enables unprecedented predictive power; however, the proper training of deep neural networks requires thousands of exemplars. Collecting this amount of data is not feasible in typical neuroimaging experiments. A handy solution to this problem, which has largely fallen outside the scope of deep learning applications in neuroimaging, is to repurpose deep networks that have already been trained on large datasets by fine-tuning them to target datasets/tasks with fewer exemplars. Here, we investigated how this method, called transfer learning, can aid age category classification and regression based on brain functional connectivity patterns derived from resting-state functional magnetic resonance imaging. We trained a connectome-convolutional neural network on a larger public dataset and then examined how the knowledge learned can be used effectively to perform these tasks on smaller target datasets collected with a different type of scanner and/or imaging protocol and pre-processing pipeline. Results: Age classification on the target datasets benefitted from transfer learning. Significant improvement (∼9%-13% increase in accuracy) was observed when the convolutional layers' weights were initialized based on the values learned on the public dataset and then fine-tuned to the target datasets. Transfer learning also appeared promising in improving the otherwise poor prediction of chronological age. Conclusions: Transfer learning is a plausible solution to adapt convolutional neural networks to neuroimaging data with few exemplars and different data acquisition and pre-processing protocols.