1.
ACS Med Chem Lett
; 2(2): 142-7, 2011 Feb 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24900293
RESUMEN
The discovery of potent and selective cyanamide-based inhibitors of the cysteine protease cathepsin C is detailed. Optimization of the template with regard to plasma stability led to the identification of compound 17, a potent cathepsin C inhibitor with excellent selectivity over other cathepsins and potent in vivo activity in a cigarette smoke mouse model.