Synergetic development assessment of transboundary watershed ecological compensation.

Ecological compensation (EC) is essential to promote the coordinated and sustainable development of the watershed. Firstly, the synergetic development index system of the watershed EC was proposed, which includes the economic benefits, water conservation, pollution treatment, and environmental supervision. Then, the order degree of subsystems was calculated. Finally, the synergetic development level of the watershed EC was evaluated. Taking the upstream (Ma'anshan) and the downstream (Nanjing) of the Chu River as the case study area, the results showed that: (1) From 2011 to 2020, the synergetic development level between Ma'anshan and Nanjing has showed an upward trend; (2) The synergetic development level of the watershed EC in the Chu River has reached basic synergy in 2020; (3) Ma'anshan concentrates on protecting the water ecological environment while Nanjing concentrates on economic growth and water pollution control will improve the synergy degree. This study can provide references for the optimization of watershed EC mechanism, and to promote watershed coordinated development.

Spatial-temporal differentiation of coupling coordination degree for green finance and green innovation efficiency: a case study in China.

Continued investment in finance and innovation is beneficial to economic development, and the joining of green system can accelerate the process of economic recovery from environmental distress. To better enhance the relationship of green finance and green innovation, it is vital to demonstrate the synergy between the two thoroughly. Thirty provinces in China are selected to examine the coupling coordination relationship between the two, specifically testing the spatial aggregation and evolutionary differences in the coupling coordination by adopting the coupling coordination degree (CCD) model, spatial autocorrelation, and kernel density estimation. Conclusions of the paper show that green finance is calculated by the EW-TOPSIS method, and the overall score of provinces is low. Using super-SBM model to evaluate green innovation, the uneven distribution of efficiency is obvious, although it is gradually increasing. The CCD in most provinces is in low-level or basic coordination, with significant regional heterogeneity. The global Moran's index becomes gradually evident with time. The local Moran scatter diagram presents a downward trend from east to west, but with more L-L aggregation provinces emerging in 2020. The center of the national kernel density curve gradually shifts to the right, indicating that the national overall synergy level is improving. Deepening the understanding of the empirical results facilitates the formulation of reasonable policies that fit the four major regions.

Rainstorm Disaster Risk Assessment and Influence Factors Analysis in the Yangtze River Delta, China.

Rainstorm disasters have had a serious impact on the sustainable development of society and the economy. However, due to the complexity of rainstorm disasters, it is difficult to measure the importance of each indicator. In this paper, the rainstorm disaster risk assessment framework was systematically proposed based on the disaster system theory and a system of corresponding indicators was established. Furthermore, the genetic algorithm optimized projection pursuit and XGBoost were coupled to assess the rainstorm disaster risk and to measure the relative importance of each indicator. Finally, the Yangtze River Delta was taken as the case study area. The results show that: the rainstorm disaster risk in the eastern and southeast is higher than those in the central and northwest of the Yangtze River Delta; the total precipitation from June to September and the top ten indicators contribute 9.34% and 74.20% to the rainstorm disaster risk assessment results, respectively. The results can provide references for decision makers and are helpful for the formulation of rainstorm adaptation strategies.

Protection of toll-like receptor 9 against lipopolysaccharide-induced inflammation and oxidative stress of pulmonary epithelial cells via MyD88-mediated pathways.

Acute lung injury (ALI) caused by lipopolysaccharide (LPS) is a common, severe clinical syndrome. Injury caused by inflammation and oxidative stress in vascular endothelial and alveolar epithelial cells is a vital process in the pathogenesis of ALI. Toll-like receptor 9 (TLR9) is highly expressed in LPS-induced ALI rats. In this study, Beas-2B human pulmonary epithelial cells and A549 alveolar epithelial cells were stimulated by LPS, resulting in the upregulation of TLR9 in a concentrationdependent manner. Furthermore, TLR9 overexpression and interference vectors were transfected before LPS administration to explore the role of TLR9 in LPS-induced ALI in vitro. The findings revealed that inhibition of TLR9 reduced inflammation and oxidative stress while suppressing apoptosis of LPS-induced Beas-2B and A549 cells, whereas TLR9 overexpression aggravated these conditions. Moreover, TLR9 inhibition resulted in downregulated protein expression of myeloid differentiation protein 88 (MyD88) and activator activator protein 1 (AP-1), as well as phosphorylation of nuclear factor-?B (NF-kappaB), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK). The phosphorylation of extracellular-regulated protein kinases 1/2 was upregulated compared to that of cells subjected to only LPS administration, and this was reversed by TLR9 overexpression. These results indicate that inhibition of TLR9 plays a protective role against LPS-induced inflammation and oxidative stress in Beas-2B and A549 cells, possibly via the MyD88/NF-kappaB and MyD88/MAPKs/AP-1 pathways.

On the Coupling and Coordination Development between Environment and Economy: A Case Study in the Yangtze River Delta of China.

The coupling and coordination development of the environment and economy (CC2E) is one of the most vital issues to sustainable development. This paper adopted the coupling coordination model, projection pursuit algorithm, and random forest model to explore the spatial-temporal evolution and influencing factors of the CC2E in the Yangtze River Delta from 2015 to 2019, respectively. The results showed that: (1) The degree of coupling coordination (DCC) of the CC2E in most cities of the Yangtze River Delta has risen from primary coordination to intermediate coordination. (2) In the spatial perspective, the distribution of DCC is correlated with geographical location. The value of DCC in the western region was significantly lower than that of the eastern cities. (3) The influencing factors results showed that the GDP in the economic subsystem and the annual average concentration of PM2.5 in the environmental subsystem were the most influencing factors of DCC in the Yangtze River Delta. The established index system of CC2E and the measurements of CC2E provide a new idea for how to achieve sustainable development. Meanwhile, this study can provide recommendations for formulating the environmental protection and economic development policy.

Risk Assessment of Urban Rainstorm Disaster Based on Multi-Layer Weighted Principal Component Analysis: A Case Study of Nanjing, China.

Nanjing city is taken as a case in this urban rainstorm disaster risk research. Using the data of meteorology and social-economy statistics of Nanjing area, the paper selected ten indicators to establish the risk assessment system of urban rainstorm disaster from the aspects of the vulnerability of hazard-affected body, the fragility of disaster-pregnant environment, and the danger of hazard factors. Multi-layer weighted principal component analysis (MLWPCA) is an extension of the principal component analysis (PCA). The MLWPCA is based on factor analysis for the division subsystem. Then the PCA is used to analyze the indicators in each subsystem and weighted to synthesize. ArcGIS is used to describe regional differences in the urban rainstorm disaster risk. Results show that the MLWPCA is more targeted and discriminatory than principal component analysis in the risk assessment of urban rainstorm disaster. Hazard-affected body and disaster-pregnant environment have greater impacts on the risk assessment of rainstorm disaster in Nanjing, but the influence of hazard factors is few. Spatially, there is a large gap in the rainstorm disaster risk in Nanjing. The areas with high-risk rainstorm disaster are mainly concentrated in the central part of Nanjing, and the areas with low-risk rainstorm disaster are in the south and north of the city.

A Machine Learning Ensemble Approach Based on Random Forest and Radial Basis Function Neural Network for Risk Evaluation of Regional Flood Disaster: A Case Study of the Yangtze River Delta, China.

The Yangtze River Delta (YRD) is one of the most developed regions in China. This is also a flood-prone area where flood disasters are frequently experienced; the situations between the people-land nexus and the people-water nexus are very complicated. Therefore, the accurate assessment of flood risk is of great significance to regional development. The paper took the YRD urban agglomeration as the research case. The driving force, pressure, state, impact and response (DPSIR) conceptual framework was established to analyze the indexes of flood disasters. The random forest (RF) algorithm was used to screen important indexes of floods risk, and a risk assessment model based on the radial basis function (RBF) neural network was constructed to evaluate the flood risk level in this region from 2009 to 2018. The risk map showed the I-V level of flood risk in the YRD urban agglomeration from 2016 to 2018 by using the geographic information system (GIS). Further analysis indicated that the indexes such as flood season rainfall, urban impervious area ratio, gross domestic product (GDP) per square kilometer of land, water area ratio, population density and emergency rescue capacity of public administration departments have important influence on flood risk. The flood risk has been increasing in the YRD urban agglomeration during the past ten years under the urbanization background, and economic development status showed a significant positive correlation with flood risks. In addition, there were serious differences in the rising rate of flood risks and the status quo among provinces. There are still a few cities that have stabilized at a better flood-risk level through urban flood control measures from 2016 to 2018. These results were basically in line with the actual situation, which validated the effectiveness of the model. Finally, countermeasures and suggestions for reducing the urban flood risk in the YRD region were proposed, in order to provide decision support for flood control, disaster reduction and emergency management in the YRD region.

[Effect of Acupuncture on Prognosis and Immune Function of Sepsis Patients].

OBJECTIVE: To study the effect of acupuncture on the immune function of sepsis patients. METHODS: Ninety sepsis patients were assigned to the control group, the thymosin a1 group, and the acupuncture treatment group according to random digit table, 30 patients in each group. Patients in the control group were treated according to the guideline of Surviving Sepsis Campaign (SSC). Patients in the control group received routine treatment. Those in the thymosin alpha1 group additionally received subdermal injection of thymosin alpha1 (1.6 mg), once per day for 6 successive days. Needling at related points such as Zusanli (ST36), Yanglingquan (GB34), Neiguan (PC6), Guanyuan (RN4), and so on, was performed in patients of the acupuncture treatment group, once per day for 6 successive days. T cell subgroups (CD3+, CD4+, CD8+, CD4+ /CD8+) and immunoglobulin levels (IgG, IgA, IgM) were detected. The length of ICU hospital stay, hospital readmission rate, and 28-day mortality were compared among the three groups. RESULTS: After six days of treatment, CD3+, CD4+, CD8+, IgG, IgA, IgM, and CD4+ /CD8+ ratio of three groups were all significantly increased (P < 0.01). Of them, CD3+, CD4+, CD8+, IgG, IgA, and IgM increased more significantly in the thymosin alpha1 group and the acupuncture treatment group (P < 0.01). Compared with the control group, the ICU hospitalization length was significantly shortened, the hospital readmission rate and the 28-day mortality were lower in the thymosin alpha1 group and the acupuncture treatment group (P < 0.05, P < 0.01). There was no statistical difference in each index between the thymosin alpha1 group and the acupuncture treatment group (P > 0.05). CONCLUSION: Acupuncture could adjust the immune function of sepsis patients, improve their immunological indicators and prognoses.

[Effect of acupuncture on acute left heart failure by PiCCO technique].

OBJECTIVE: To observe the clinical effect of acupuncture on acute heart failure (AHF) patients. METHODS: Totally 60 patients who were diagnosed as AHF were assigned to the acupuncture group and the control group, 30 in each group. Those in the control group received inotropic agents, preload and afterload reducing therapy, anti-infection and so on. Besides, those in the acupuncture group received needling at relative points, once daily for 5 consecutive days. The mean arterial pressure (MAP), heart rate (HR), cardiac index (CI), stroke volume index (SI), left ventricle working index (LCWI) were monitored by thermodilution pulse-indicated continuous cardiac output (PiCCO) technique. Changes of the aforesaid data were compared between before and after treatment. The ICU length of stay, readmission rate,and the 28-day mortality were also compared between the two groups. RESULTS: After 5 days of the treatment, CI, SI, and LCWI increased more obviously (P < 0.01), HR and MAP decreased significantly (P < 0.05). Of them, CI, SI, and LCWI increased more obviously in the acupuncture group (P < 0.05).There was no obvious difference in HR or MAP between the two groups (P > 0.05). Compared with the first day of admission in the same group, CI, SI, and LCWI obviously increased in the acupuncture group from the second day (P < 0.05). HR started to decrease since the fourth day (P < 0.05), and MAP began to decrease until the fifth day (P < 0.05). CI, SI, and LCWI started to increase in the control group from the third day (P < 0.05); HR and MAP both began to decrease since the fifth day (P < 0.05). Compared with the control group, the ICU length of stay was obviously shortened in the acupuncture group (P < 0.05). The readmission rate and the 28-day mortality rate were lower than those of the control group (P < 0.05). CONCLUSION: The combination of acupuncture and Western medical therapy might strengthen acute heart failure patients' heart functions, elevate the therapeutic effect, and improve the prognosis.