Catalytic Hairpin Assembly-Based Self-Ratiometric Gel Electrophoresis Detection Platform for Reliable Nucleic Acid Analysis.

The development of gel electrophoresis-based biodetection assays for point-of-care analysis are highly demanding. In this work, we proposed a ratiometric gel electrophoresis-based biosensing platform by employing catalytic hairpin assembly (CHA) process functions as both the signal output and the signal amplification module. Two types of nucleic acids, DNA and miRNA, are chosen for demonstration. The proposed strategy indeed provides a new paradigm for the design of a portable detection platform and may hold great potential for sensitive diagnoses.

Characterizing atom clouds using a charge-coupled device for atom-interferometry-based G measurements.

Precise information of positions and sizes of atom clouds is required for atom-interferometry-based G measurements. In this work, characterizing atom clouds using a charge-coupled device (CCD) is presented. The parameters of atom clouds are extracted from fluorescence images captured by the CCD. For characterization, in-situ calibration of the magnification of the imaging system is implemented using the free-fall distance of atom clouds as the dimension reference. Moreover, influence of the probe beam on measuring the positions of atom clouds is investigated, and a differential measurement by reversing the direction of the probe beam is proposed to suppress the influence. Finally, precision at sub-mm level for characterizing atom clouds is achieved.

Influence of magnetic field on the seismometer in vibration correction for atom gravimeters.

Vibration correction provides a simple and flexible method of suppressing ambient vibration noise in transportable atom gravimeters. However, in the seismometers used for vibration correction, a spurious output may be induced by the magnetic field of the magnetic-optical trap, introducing errors to the gravity measurements. This paper evaluates the influence of the magnetic field on the seismometer and the corresponding errors in the gravity measurements. It is found that an error level of order 10 µGal may be present if the seismometer is not configured carefully. The dependence of the influence on the orientation of the seismometer and the lasting time of the magnetic field are investigated. The effective suppression of the influence by shielding the seismometer is also demonstrated. Our results focus attention on the possible errors related to seismometers in high-precision gravity measurements by using atom gravimeters.

A dual-magneto-optical-trap atom gravity gradiometer for determining the Newtonian gravitational constant.

As part of a program to determine the gravitational constant G using multiple independent methods in the same laboratory, an atom gravity gradiometer is being developed. The gradiometer is designed with two magneto-optical traps to ensure both the fast simultaneous launch of two atomic clouds and an optimized configuration of source masses. Here, the design of the G measurement by atom interferometry is detailed, and the experimental setup of the atom gravity gradiometer is reported. A preliminary sensitivity of 3 × 10-9 g/Hz to differential gravity acceleration is obtained, which corresponds to 99 E/Hz (1 E = 10-9 s-2) for the gradiometer with a baseline of 0.3 m. This provides access to measuring G at the level of less than 200 parts per million in the first experimental stage.

Measuring the effective height for atom gravimeters by applying a frequency jump to Raman lasers.

As the existence of the gravity gradient, the output of gravimeters is actually the gravitational acceleration at the reference instrumental height. Precise knowledge of the reference height is indispensable in the utilization of gravity measurements, especially for absolute gravimeters. Here, we present an interferometric method to measure the distance between the atomic cloud and a reflecting mirror directly, which consequently determines the reference height of our atom gravimeter. This interferometric method is based on a frequency jump of Raman lasers applied at the π pulse of the atom interferometer, which induces an additional phase shift proportional to the interested distance. An uncertainty of 2 mm is achieved here for the distance measurement, and the effect of the gravity gradient on absolute gravity measurements can thus be constrained within 1 µGal. This work provides a concrete-object-based measurement of the reference height for atom gravimeters.

Test of the Universality of Free Fall with Atoms in Different Spin Orientations.

We report a test of the universality of free fall by comparing the gravity acceleration of the ^{87}Rb atoms in m_{F}=+1 versus those in m_{F}=-1, of which the corresponding spin orientations are opposite. A Mach-Zehnder-type atom interferometer is exploited to alternately measure the free fall acceleration of the atoms in these two magnetic sublevels, and the resultant Eötvös ratio is η_{S}=(0.2±1.2)×10^{-7}. This also gives an upper limit of 5.4×10^{-6} m^{-2} for a possible gradient field of the spacetime torsion. The interferometer using atoms in m_{F}=±1 is highly sensitive to the magnetic field inhomogeneity. A double differential measurement method is developed to alleviate the inhomogeneity influence, of which the effectiveness is validated by a magnetic field modulating experiment.