RESUMEN
The photophysical properties of a new series of fluorenyl porphyrins bearing water-solubilising oligoethyleneglycol chains are described. These biocompatible compounds present very good two-photon absorption and singlet oxygen generation properties, while retaining some fluorescence in water. After testing in vitro on breast cancer cells, some of them were shown to be efficient non-toxic two-photon photosensitisers allowing for fluorescence imaging, thus demonstrating their theranostic potential.
Asunto(s)
Fluorenos/química , Fotoquimioterapia/métodos , Fármacos Fotosensibilizantes/química , Porfirinas/química , Materiales Biocompatibles/química , Permeabilidad de la Membrana Celular , Supervivencia Celular/efectos de los fármacos , Humanos , Rayos Infrarrojos , Células MCF-7 , Microscopía de Fluorescencia por Excitación Multifotónica/métodos , Estructura Molecular , Imagen Óptica/métodos , Polietilenglicoles/química , Oxígeno Singlete/química , Relación Estructura-ActividadRESUMEN
In the title complex, [Co(C6H15N2)Cl3], the Co(2+) ion is coordinated in a distorted tetra-hedral fashion by three chloride ions and one N atom of the piperazine ring; the ring adopts a chair conformation with the N-Co and N-CEt bonds in equatorial orientations. In the crystal, mol-ecules are connected by N-Hâ¯Cl hydrogen bonds, generating (10-1) sheets.
RESUMEN
In the title mol-ecular salt, (C10H16N2)[CoCl4], the piperazine ring of the phenyl-piperazine dication adopts a chair conformation and the phenyl ring occupies an equatorial orientation. In the tetra-chlorido-cobaltate(II) dianion, the Co-Cl bond lengths for the chloride ions not accepting hydrogen bonds are significantly shorter than those for the chloride ions accepting such bonds. In the crystal, the components are linked by N-Hâ¯Cl hydrogen bonds, generating [001] chains.
