A 4-session written emotional disclosure intervention lowers 6-month sympathoadrenal urinary output in persons living with HIV.

OBJECTIVE: We previously reported that a brief guided written emotional disclosure (WED) intervention resulted in significant reductions in post-traumatic stress disorder (PTSD) symptomology in women, but not men, living with HIV. Levels of 24-hour urinary output of epinephrine (E) and norepinephrine (NE) are shown to be elevated in persons diagnosed with PTSD. The current study tested whether there was an effect for the 4-week WED intervention on 6-month change in urinary E and NE output amongst persons living with HIV. METHOD: Fourteen women and 11 men living with HIV randomized to four 30-min expressive writing sessions of either trauma writing or daily events writing in the parent trial were included based upon collection of urine specimens at baseline, 1-, and 6-months after the intervention. Total volume (µg) and concentration (µg/ml) of urinary E and NE were derived from the specimens as study outcomes. RESULTS: Four repeated measures analyses of covariance (ANCOVA) were performed to evaluate study outcomes using trauma- versus daily-writing as the between-subject factors and collection time point as the within-subject factor, controlling for age and sex. A group x time interaction was observed wherein the trauma writing treatment group showed a significantly greater decrease in total urinary output, F(2, 46) = 4.03, p = .03, and concentration, F(2, 46) = 4.74, p = .01 of epinepherine. Post-hoc analyses revealed the interaction effect for the total, F(2, 22) = 4.82, p = .03, and concentration, F(2, 22) = 7.57, p = .005, of urinary E output over 6-months was significant for women. Interactions were not observed in urinary NE output. CONCLUSIONS: Significant reductions in the total output and concentration of urinary E were found up to 6-months following initiation of a 4-session guided written emotional disclosure intervention. Profiles of sympathoadrenal activity and response to expressive writing differ between men and women living with HIV. Futher research is need to characterize the putative pathways linking sympathoadrenal response to upstream neurobiological function and downstream inflammatory-immune status in women living with HIV and PTSD.

Does emotion regulation network mediate the effect of social network on psychological distress among older adults?

Socio-emotional interactions are integral for regulating emotions and buffering psychological distress. Social neuroscience perspectives on aging suggest that empathetic interpersonal interactions are supported by the activation of brain regions involved in regulating negative affect. The current study tested whether resting state functional connectivity of a network of brain regions activated during cognitive emotion regulation, i.e., emotion regulation network (ERN), statistically mediates the frequency of social contact with friends or family on psychological distress. Here, a 10-min resting-state functional MRI scan was collected along with self-reported anxiety/depressive, somatic, and thought problems and social networking from 90 community-dwelling older adults (aged 65-85 years). The frequency of social interactions with family, but not friends and neighbors, was associated with lower psychological distress. The magnitude of this effect was reduced by 33.34% to non-significant upon adding resting state ERN connectivity as a mediator. Follow-up whole-brain graph network analyses revealed that efficiency and centrality of the left inferior frontal gyrus and the right middle temporal gyrus relate to greater family interactions and lower distress. These hubs may help to buffer psychological problems in older adults through interactions involving empathetic and cognitive emotion regulation with close family.

Neutrophil-to-Lymphocyte Ratio Amplifies the Effects of Aging on Decrements in Grip Strength and Its Functional Neural Underpinnings.

The neutrophil-to-lymphocyte ratio (NLR) is a trans-prognostic biomarker of physiologic stress and inflammation linked to muscle weakness in older adults. Generation of grip force coincides with sustained activity in the primary sensorimotor cortex (SM1). The current study investigates whether whole-brain functional connectivity, that is, degree centrality (CD) of SM1 relates to grip strength and whether both functional measures are predicted by advancing age as a function of the NLR. A structural regression model investigated the main and interactive effects of age and NLR on grip strength and CD of SM1 in 589 adults aged 21-85 years (M = 45.87, SD = 18.06). The model including the entire sample had a good fit (χ 2(4) = 1.63, p = .804). In individuals aged 50 years and older, age predicted lower grip strength and SM1 CD as a function of increasing NLR. In a model stratified by sex, the effect of age, NLR, and their interaction on grip strength are significant for older men but not older women. Analyses support CD of SM1 at rest as a neural biomarker of grip strength. Grip and its neural underpinnings decrease with advancing age and increasing NLR in mid to late life. Age-related decrements in grip strength and functional connectivity of brain regions involved in the generation of dynamic grip appear to be accelerated as a function of systemic physiological stress and inflammation, particularly in older men.

Circulating endothelial and angiogenic cells predict hippocampal volume as a function of HIV status.

Circulating endothelial cells (CECs) and myeloid angiogenic cells (MACs) have the capacity to stabilize human blood vessels in vivo. Evidence suggests that these cells are depleted in dementia and in persons living with HIV (PWH), who have a higher prevalence of dementia and other cognitive deficits associated with aging. However, the associations of CECs and MACs with MRI-based measures of aging brain health, such as hippocampal gray matter volume, have not been previously demonstrated. The present study examined differences in these associations in 51 postmenopausal women with and without HIV infection. Gray matter volume was quantified using MRI. CECs and MACs were enumerated using fluorescence-activated cell sorting. Analyses examined the association of these cell counts with left and right hippocampal gray matter volume while controlling for age and hypertension status. The main finding was an interaction suggesting that compared to controls, postmenopausal PWH with greater levels of CECs and MACs had significantly greater hippocampus GMV. Further research is necessary to examine potential underlying pathophysiological mechanisms in HIV infection linking morpho-functional circulatory reparative processes with more diminished hippocampal volume in postmenopausal women.

Own-age bias in face-name associations: Evidence from memory and visual attention in younger and older adults.

Successfully learning and remembering people's names is a challenging memory task for adults of all ages, and this already difficult social skill worsens with age, even in normative "healthy" aging. The own-age bias, a type of in-group bias, could affect the difficulty of this task across age. Past evidence supports an own-age bias in face processing, wherein individuals preferably attend to and better recognize faces of members of their own age group. However, the own-age bias has not been examined previously in relation to explicit face-name associative encoding and subsequent name retrieval, despite the importance of this social skill. Using behavioral and eye-tracking methodology, this cross-sectional research investigated the own-age bias for name memory (recognition and recall) and visual attention (fixation count, looking time, and normalized pupil size) when learning novel face-name pairs. Younger adult (n = 90) and older adult (n = 84) participants completed a face-name association task that tested name memory for younger and older female and male faces, while eye-tracking data were recorded. The visual attention variables taken from the eye-tracking data showed significant age-of-face effects at both encoding and retrieval, but no overall own-age bias in attention. Both younger and older participants showed an own-age bias in name recall with better memory for names paired with faces of their own age, as compared to other-aged faces. This cross-over effect for name memory suggests that memory for information with high social and affective relevance to the individual may be relatively spared in aging, despite overall age-related declines in memory performance.

Transforming ICoN into iCaN, Healthy Lifestyles for College Nursing Students: Implementing the Marylin Bagwell Leadership Development Grant.

Transforming iCoN into iCaN": This was the mantra for the student leaders of the University of Cincinnati Student Nurses' Association (UC SNA) for the past academic year. In March 2015, the UC SNA was awarded the Marilyn Bagwell Leadership Development Grant for the 2015-2016 academic year. Although this grant project encompassed nutrition education and improvement of healthy lifestyles for our nursing students for this past academic year, the UC SNA has promoted events in past years that involved increasing physical activity and healthy eating habits. However, the UC SNA student leaders felt strongly that it was very important to provide a more structured, holistic program for our students than to just offer sporadic events, and to make this the purpose of UC SNA. This thought process led to the variety of activities and events that were offered this past year. In 2013, the UC College of Nursing integrated AppleTM products into our learning, and coined the term "iCoN" to refer to this initiative. This was incorporated into the title of our project, as it truly encompassed multiple initiatives of the UC College of Nursing.