Offending and the Long-Term Risk of Death: An Examination of Mid-Life Mortality Among an Urban Black American Cohort.

Research on the long-term relationship between offending and mortality is limited, especially among minorities who have higher risk of premature mortality and criminal offending, particularly arrest. Using Cox proportional hazard models, we estimate the relationship between young adult offending and later mortality (to age 58) among a community cohort of Black Americans (n = 1,182). After controlling for a wide range of covariates, results indicate that violent offenders are at heightened risk of mortality from young adulthood through midlife compared with both non-violent only offenders and non-offenders. Further analysis shows that this result is driven by the frequent, largely non-violent, arrests incurred among violent offenders. Criminal justice reform and collaboration with public health practitioners might be fruitful avenues to reduce mortality disparities.

Can Early Disadvantage Be Overcome? A Life Course Approach to Understanding How Disadvantage, Education, and Social Integration Impact Mortality into Middle Adulthood Among a Black American Cohort.

Health equity research has identified fundamental social causes of health, many of which disproportionately affect Black Americans, such as early life socioeconomic conditions, neighborhood disadvantage, and racial discrimination. However, the role of life course factors in premature mortality among Black Americans has not been tested extensively in prospective samples into later adulthood. To better understand how social factors at various life stages impact mortality, this study examines the effect of life course poverty, neighborhood disadvantage, and discrimination on mortality and factors that may buffer their effect (i.e., education, social integration) among the Woodlawn cohort (N = 1242), a community cohort of urban Black Americans followed since 1966. Taking a life course perspective, we analyze mortality data for deaths through age 58 years old, as well as data collected at ages 6, 16, 32, and 42. At age 58, 204 (16.4%) of the original cohort have died, with ages of death ranging from 9 to 58.98 (mean = 42.9). Cox proportional hazard models adjusting for confounders show statistically significant differences in mortality risk based on timing and persistence of poverty; those who were never poor or poor only in early life had lower mortality risk at ages 43-58 than those who were persistently poor from childhood to adulthood. Education beyond high school and high social integration were shown to reduce the risk of mortality more for those who did not experience poverty early in their life course. Findings have implications for the timing and content of mortality prevention efforts that span the full life course.

Cohort Profile: The Woodlawn Study.

The Woodlawn Study is an epidemiologically- defined community cohort study of 1242 Black Americans (51% female and 49% male), who were in first grade in 1966-67 in Woodlawn, a neighborhood of Chicago, Illinois. The study comprises extensive interview data over the life course including self-, mother-, and/or teacher-reported assessments at ages 6, 16, 32, 42, and 62 (in progress), administrative records (i.e., education, crime, and death records), and census data. These data cover a wide range of focal areas across the life course, including family environment, socioeconomic indicators, education, social integration (e.g., marriage, community engagement, religious involvement) and social support, employment, racial discrimination, substance use, crime/victimization, and mental and physical health, including mortality. Over the past 50 years, Woodlawn research has mapped cumulative disadvantage, substance use, and criminal offending and has identified key risk and protective factors of adversity, resilience, and success across the full life course. In turn, these findings have informed life course theory and policy for a population that experiences significant criminal and health disparities.

Does Early Adolescent Arrest Alter the Developmental Course of Offending into Young Adulthood?

Adolescent involvement in risky behavior is ubiquitous and normative. Equally pervasive is the rapid decline in risky behavior during the transition to adulthood. Yet, for many, risky behavior results in arrest. Whereas prior research finds that arrest is associated with an increased risk of experiencing a host of detrimental outcomes, less understood is the impact of an arrest on the developmental course of offending compared to what it would have looked like if no arrest had occurred-the counterfactual. This study examines the developmental implications of an arrest early in the life course. The sample (N = 1293) was 37% female, 42% non-white, with a mean age of 13.00 years (SD = 0.82, range = 12-14) at baseline and followed annually for 15 years. Analyses combine propensity score matching and multilevel modeling techniques to estimate the impact of early arrest (i.e., 14 or younger) on the development of offending from adolescence into adulthood. The results indicate that early arrest alters the developmental course of offending in two primary ways. First, early arrest heightens involvement, frequency, and severity of offending throughout adolescence and into early young adulthood even after controlling for subsequent arrests. The detrimental influence of early arrest on the developmental course of offending is found regardless of gender or race/ethnicity. Second, even among youth with an early arrest, offending wanes over time with self-reported offending among all youth nearly absent by the mid- to late-twenties. The findings advance understanding of the developmental implications of early arrest beyond typical and expected offending.

Long-term Consequences of Criminal Justice System Intervention: The Impact of Young Adult Arrest on Midlife Health Behaviors.

While there is a growing literature on the relationship between incarceration and health, few studies have expanded the investigation of criminal justice system involvement and health to include the more common intervention of arrest. This study uses a quasi-experimental design to evaluate the long-term effect of arrest in young adulthood on health behaviors in midlife for African Americans. We use propensity score matching methods and gender-specific multivariate regression analyses to equate those who did and did not incur an arrest in young adulthood from a subsample (n = 683) of the Woodlawn cohort, an African American community cohort followed from childhood into midlife. The results suggest that, for men, having been arrested in young adulthood has a direct effect on smoking, daily drinking, and risky sexual behaviors into midlife while young adult arrest does not seem to impact midlife health risk behaviors for women. This study adds health risk behaviors to the growing list of detrimental outcomes, such as crime, drug use, education, and mental health that are related to criminal justice contact for African American men, in particular.

What Protects Those at High Risk from Criminal Justice Contact Despite the Odds? A Negative Case Analysis.

Criminal justice contact is a prevalent, if not expected, life event for many high-risk individuals with deleterious consequences; yet, many individuals at high risk are able to avoid this contact (i.e. negative cases exist). In this study, we draw on the life course framework and utilize negative case analysis to (1) estimate the prevalence of criminal justice avoidance within a sample of structurally high-risk Black men and (2) explore the individual, familial and contextual factors in childhood and adolescence that distinguish these negative cases. One's own 'on-time' and one's siblings' education emerge as particularly strong protective factors suggesting that the presence of unique protection, as opposed to the absence of risk, may be most salient. Theoretical implications are discussed.

What's drugs got to do with it? Examining the relationship between drug onset and duration with criminal outcomes in an African American cohort.

BACKGROUND: The association of drug use onset and duration with criminal careers has rarely been studied over the life course among African Americans, who are disproportionately impacted by the criminal justice system. METHODS: This study uses data from a community cohort of urban African Americans, first assessed at age 6 (n = 1242) and followed into midlife. Data come from both self-reports (n = 1053 in adulthood) and official crime records (n = 1217). Regression analyses among those who used marijuana, cocaine, and/or heroin and had complete arrest data (n = 614) assess the association between adolescent vs. adult initiation, short vs. long duration of use, and their interaction with the outcomes of arrest, incarceration, and criminal career length, as well as meeting criteria for a drug use disorder. RESULTS: Findings show that onset and duration are highly related, but when independent effects of duration and onset are assessed, only duration is a statistically significant predictor of all four crime outcomes, as well as a predictor of meeting criteria for a drug use disorder in adjusted regression models. Associations of duration with arrests held for all crime types (i.e., drug, property, violence). Adolescent vs. adult drug onset only predicted meeting lifetime criteria for a drug use disorder. The interaction of onset and duration was not statistically significant in any models. No appreciable differences were observed in gender specific models. DISCUSSION: Findings suggest that shortening drug use duration may have a greater impact on reducing the association of drug use with crime for African Americans than delaying onset.

Explaining continuity in substance use: The role of criminal justice system involvement over the life course of an urban African American prospective cohort.

BACKGROUND: African Americans are disproportionately burdened by substance use consequences and criminal justice system involvement, yet their interrelationship over the life course is not well understood. This study aimed to assess how substance use, crime, and justice system involvement may influence one another from adolescence to midlife. METHODS: Data come from a community cohort of urban African Americans first assessed in childhood and followed up into midlife (n = 1242, 606 males, 636 females). We draw on interview data and local, state, and federal criminal records. Participants were assessed at ages 6, 16, 32, and 42, with additional record retrieval at age 52. Utilizing structural equation modeling, we estimate pathways between substance use, criminal behavior, and arrests over time by gender. RESULTS: For males, significant paths were found between childhood behavioral problems and adolescent substance use, delinquency, and police interactions. For females, a significant path was found between childhood behavioral problems and only adolescent delinquency. We observed continuity between substance use and between arrest constructs from adolescence through midlife for men only. Direct paths were found between substance use and later arrests for both males and females. Paths were also observed between arrests and later substance use for both genders. CONCLUSIONS: Findings of reciprocal relationships highlight the critical need to break the cycle of substance use and crime and point to specific times in the life course when intervention is necessary. Findings introduce the potential role of the criminal justice system as a key intervention agent in redirecting substance use careers.

Young Adult Victimization and Midlife Consequences: Sensitization or Steeling Effects of Childhood Adversity?

The interrelationship between victimization, violence, and substance use/abuse has been well established, yet those who experience victimization do not necessarily respond with violence or substance use or escalate to experiencing substance abuse symptoms. Drawing on literature from both the syndemic research from medical anthropology and the resilience research from psychology, this study examines the interaction between early childhood adversity and young adult violent victimization on later substance use/abuse and violent offending to provide insight into conditional effects. Data are derived from the Woodlawn Study, an African American cohort of men and women from a socioeconomically heterogeneous community in the South Side of Chicago, who were followed from first grade through age 42. Results indicate that those with lower levels of childhood adversity are more likely to suffer the negative consequences of violent victimization than those with higher childhood adversity, providing support for a "steeling" effect.

Understanding the Role of Marriage in Black Women's Offending Over the Life Course.

Purpose: Black women remain a traditionally understudied population in life course criminology and in studies of criminal desistance specifically. This work contributes to the desistance literature by focusing on within-group heterogeneity among black women, and examining whether variation in the structural position (measured at both distal and proximate points in the life course) conditions the relationship between a well-recognized correlate of desistance-marriage-and offending. Methods: The sample of 636 black females is drawn from the Woodlawn project, a longitudinal, interdisciplinary study of social adaptation, psychological well-being, and crime in a Chicago community cohort of black Americans who were in first grade in 1966. To test for potential moderating effects of structural position on the marriage-offending link, we employ hierarchical linear modeling (HLM) to simultaneously estimate variation in crime within-individuals while accounting for between-individual differences in offending. Results: Findings suggest that both childhood and adult measures of structural position condition the marriage-offending link in important ways. Most notably, black women who are more socioeconomically disadvantaged reap greater benefits from marriage-in the form of a reduced probability of offending-than their more advantaged counterparts. Conclusion: To the degree that women's pathways to offending are shaped by their socioeconomic marginalization, the practical benefits of marriage (e.g., economic improvement) might surpass other traditionally recognized mechanisms of desistance (e.g., social bonds) in their importance. Future life course research should highlight the complexity of lived experiences by explicitly considering one's race, gender, and social-structural position.

Why Don't More Black Americans Offend? Testing a Theory of African American Offending's Ethnic-Racial Socialization Hypothesis.

Criminology is replete with research on the correlates of African American offending, yet theorizing efforts have lagged. Unnever and Gabbidon recently proposed a Theory of African American Offending, an integrated explanation of African Americans' risks for and resilience to offending. Many of the theory's hypotheses remain untested, especially its major claim that positive ethnic-racial socialization is the main reason more Black Americans do not offend. The theory argues that positive ethnic-racial socialization inhibits African American offending by attenuating the criminogenic effect of weak social bonds. Using data from a prospective, longitudinal cohort of African Americans from the Woodlawn Project, we test whether these postulations hold for adolescent delinquency and adult offending and find general support: Positive ethnic-racial socialization buffers the effect of weak school bonds on adolescent substance use and adult offending for males, but not females, across most crime types. Advancing criminological discourse on race, offending, and resilience, this study has implications for broader criminological theorizing and crime-reduction efforts.

Unpacking the paradox of neighboring ties: the moderating effect of criminal context on victimization.

The consistency of the finding that neighboring ties produce social control has been challenged in recent work, leading to more nuanced theorizing. Negotiated coexistence theory posits that neighboring ties between criminal and non-criminal residents reduce social control by increasing the negotiating power of the criminal element. The present study tests whether criminal context moderates the relationship between neighboring and victimization. The effect of neighboring, criminal context, and their interaction on victimization outcomes is estimated while controlling for neighborhood disadvantage using ordinary least squares regression among an urban African American cohort. In support of negotiated coexistence theory, findings show that involvement in neighboring within a criminal context is associated with higher violent victimization among men in young adulthood, while neighboring within a non-criminal context is associated with lower young men's violent victimization. Yet, this relationship does not hold for men in midlife. In contrast, neighboring is associated with lower property victimization regardless of criminal context for women, in line with social disorganization theory; yet, this relationship was only evident in midlife with no such relationship emerging in young adulthood.

Neurodevelopmental outcome in survivors of hypoxic ischemic encephalopathy without cerebral palsy.

To access outcome following hypoxic ischemic encephalopathy (HIE), survivors without cerebral palsy were invited for formal developmental assessment. Children aged ≥ 42 months were assessed using the NEPSY-2, Movement Assessment Battery for Children 2 (Movement ABC-2), Behavior Rating Inventory of Executive Function, and the Child Behavior Checklist. Children aged < 42 months were assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (BSITD-3). One hundred forty-six children attended for assessments [Grade 1 (112), Grade 2 (33), and Grade 3 (1)]. BSITD-3 did not identify significant rates of impairment on cognitive, motor, or language subtests. A significant proportion of children scored < 3rd percentile on the adaptive behavior scale. In older age groups, difficulties were seen in 16/24 NEPSY-2 subtests and on timed assessments using Movement ABC-2. Difficulties arose especially in the "control" aspects of cognition and behavior. Behavioral difficulties were common with internalizing problems predominating. There was a graded effect with grade 2 cases differing significantly from grade 1 cases. CONCLUSION: Following HIE, children may experience attention, memory, and behavior difficulties which are not always evident at a young age. The adaptive behavior questionnaire may be a useful tool to select children requiring developmental surveillance beyond 2 years of age. What is known: • Diversity of outcome across grades of HIE is reported and few studies have looked at the milder consequences of HIE at school age. What is new: • Following HIE children may experience attention, memory, and behavior difficulties which are not always evident at a young age. • The adaptive behavior questionnaire may be a useful tool to select children requiring developmental surveillance beyond 2 years of age.

Long-term consequences of adolescent cannabis use: Examining intermediary processes.

BACKGROUND: In the United States, perceptions of marijuana's acceptability are at an all-time high, risk perceptions among youth are low, and rates are rising among Black youth. Thus, it is imperative to increase the understanding of long-term effects of adolescent marijuana use and ways to mitigate adverse consequences. OBJECTIVES: To identify the midlife consequences of heavy adolescent marijuana use and the mechanisms driving effects among a Black, urban population. METHODS: This study analyzed the propensity score-matched prospective data from the Woodlawn Study, a community cohort study of urban Black youth followed from ages 6-42. After matching the 165 adolescents who used marijuana heavily to 165 non-heavy/nonusers on background confounders to reduce selection effects (64.5% male), we tested the association of heavy marijuana use by age 16 with social, economic, and physical and psychological health outcomes in midlife and the ability of adult drug trajectories (marijuana, cocaine, and heroin use from ages 17-42) and school dropout to mediate effects. RESULTS: Heavy adolescent marijuana use was associated with an increased risk of being poor and of being unmarried in midlife. Marijuana use also predicted lower income and greater anxious mood in midlife. Both adult drug use trajectories and school dropout significantly mediated socioeconomic effects but not marital or anxious mood outcomes. CONCLUSION: Heavy adolescent marijuana use seems to set Black, urban youth on a long-term trajectory of disadvantage that persists into midlife. It is critical to interrupt this long-term disadvantage through the prevention of heavy adolescent marijuana use, long-term marijuana and other drug use, and school dropout.

Examining the Consequences of the "Prevalent Life Events" of Arrest and Incarceration among an Urban African-American Cohort.

The life course perspective has traditionally examined prevalent adult life events, such as marriage and employment, and their potential to redirect offending trajectories. However, for African Americans, the life events of arrest and incarceration are becoming equally prevalent in young adulthood. Therefore, it is critical to understand how these "standard" criminal justice practices, which are designed to deter as well as punish, affect deviance among this population. This study evaluates the long-term consequences of criminal justice intervention on substance use and offending into midlife among an African American community cohort using propensity score matching and multivariate regression analyses. The results largely point to a criminogenic effect of criminal justice intervention on midlife deviance with a particularly strong effect of young adult arrest on rates of violent and property arrest counts into midlife. The theoretical and policy implications of the findings are discussed.

Pathways from Early Childhood Adversity to Later Adult Drug Use and Psychological Distress: A Prospective Study of a Cohort of African Americans.

Drawing on the life course perspective, this research addresses the direct and indirect pathways between childhood adversity and midlife psychological distress and drug use across a majority of the life span in an African American cohort (N = 1,242) followed from age 6 to 42 (1966 to 2002). Results from structural equation models highlight the impact of low childhood socioeconomic status (SES), poor maternal mental health, and the role of first-grade maladaptation in launching a trajectory of social maladaptation from age 6 to 42. Specifically, for men, we found a direct pathway from early low SES to drug use in mid adulthood and an indirect pathway to psychological distress through first-grade maladaptation and adolescent poor mental health. For females, early SES affected first-grade maladaptation and low school bonds, which then predicted later drug use.

Understanding the Mechanisms of Desistance at the Intersection of Race, Gender, and Neighborhood Context.

OBJECTIVES: This study tests theorized mechanisms of desistance, and whether the process of desistance is conditioned by social structural position. METHODS: We investigate how marriage promotes desistance from crime among urban African American males raised in the Woodlawn community, a disadvantaged neighborhood in Chicago. Using hierarchical linear modeling, we test the resiliency of the marriage effect by observing offending trajectories following marital dissolution; is the marriage effect conditional upon staying married, indicating situational effects? or does the effect persist when marriage is taken away, indicating enduring effects? Further, we test if the process of desistance is conditional upon contextual disadvantage. RESULTS: While initial findings show an increase in violent and property offending upon divorce, further analysis shows evidence that this effect differs by neighborhood structural context; the increase in offending upon divorce is apparent only for African American men who experience continued disadvantage across the life course. Those who moved to relatively more advantaged areas by adulthood show no increase in offending upon marital dissolution. CONCLUSIONS: How marriage matters for desistance is partially influenced by social structural position; context matters. These findings invigorate criminological research on the mechanisms driving the marriage effect and provide insight into the interactive nature of person and context.

Brain magnetic resonance imaging and outcome after hypoxic ischaemic encephalopathy.

OBJECTIVE: To correlate pattern of injury on neonatal brain magnetic resonance imaging (MRI) with outcome in infants ≥36 + 0 weeks gestation with hypoxic ischaemic encephalopathy. METHODS: Prospective cohort study. Images were blindly reviewed. Children were assessed using a variety of standardised assessments. RESULTS: MRI brain was performed on 88 infants. Follow up was available in 73(83%) infants. Eight of 25(32%) children with normal imaging had below normal assessment scores. Eight infants (12%) had isolated punctate white matter lesions and five of these had abnormal assessment scores. Death and cerebral palsy were seen only in children with imaging scores ≥3 on basal ganglia/thalami (BGT) score or ≥4 on watershed score. No developmental concerns were raised in 3/7(43%) infants with isolated watershed injury. Ten of 13(77%) infants with isolated BGT injury died or developed cerebral palsy. All 23 children with posterior limb of the internal capsule (PLIC) injury displayed developmental difficulties. CONCLUSIONS: Almost one-third of infants with a normal MRI brain may be at risk of developmental problems. Punctate foci of white matter injury are common and not always benign. PLIC involvement is usually associated with neurological sequelae including isolated cognitive deficits. Worst outcomes are associated with basal ganglia injury.

Predicting the Pathogenic Potential of BRCA1 and BRCA2 Gene Variants Identified in Clinical Genetic Testing.

OBJECTIVES: Missense variants are very commonly detected when screening for mutations in the BRCA1 and BRCA2 genes. Pathogenic mutations in the BRCA1 and BRCA2 genes lead to an increased risk of developing breast, ovarian, prostate and/or pancreatic cancer. This study aimed to assess the predictive capability of in silico programmes and mutation databases in assisting diagnostic laboratories to determine the pathogenicity of sequence-detectable mutations. METHODS: Between July 2011 and April 2013, an analysis was undertaken of 13 missense BRCA gene variants that had been detected in patients referred to the Genetic Health Services New Zealand (Northern Hub) for BRCA gene analysis. The analysis involved the use of 13 in silico protein prediction programmes, two in silico transcript analysis programmes and the examination of three BRCA gene databases. RESULTS: In most of the variants, the analysis showed different in silico interpretations. This illustrates the interpretation challenges faced by diagnostic laboratories. CONCLUSION: Unfortunately, when using online mutation databases and carrying out in silico analyses, there is significant discordance in the classification of some missense variants in the BRCA genes. This discordance leads to complexities in interpreting and reporting these variants in a clinical context. The authors have developed a simple procedure for analysing variants; however, those of unknown significance largely remain unknown. As a consequence, the clinical value of some reports may be negligible.