RESUMEN
Rotavirus infection is a significant cause of childhood morbidity and mortality worldwide. Although infection primarily causes gastroenteritis and dehydration, systemic signs and neurologic manifestations in rotavirus infection are widely recognized. The pathophysiologic origins of neurologic signs in rotavirus infection remain incompletely understood. We present a 4-year-old girl with clinical features of severe cerebellitis in association with abnormalities detected on magnetic resonance imaging. Rotavirus nucleic acid was demonstrated in both serum and cerebrospinal fluid. Severe neurologic sequelae remain after 2 years of follow-up. This report adds further evidence supporting a direct role for rotavirus in neurologic illness.
Asunto(s)
Enfermedades Cerebelosas/etiología , Enfermedades Cerebelosas/virología , Infecciones por Rotavirus/complicaciones , Preescolar , Femenino , Humanos , Imagen por Resonancia Magnética , Rotavirus/genética , Infecciones por Rotavirus/patologíaRESUMEN
BACKGROUND: Streptococcus pneumoniae (SP) is an uncommon cause of neonatal sepsis. AIMS: To report on the spectrum of morbidity associated with SP infections in the neonatal period. METHODS: A case series of SP infection in the neonatal period was studied. Maternal and neonatal outcomes were noted. RESULTS: Four cases of neonatal SP infection are reported, one of which was due to a strain with reduced susceptibility to penicillin. All four cases had very early onset of severe clinical disease with bacteremia and pneumonia. In one case a retrospective diagnosis of meningitis was made as well. Maternal illness was a feature in one of these infants. CONCLUSIONS: Although less common now than in the pre-antibiotic era, Streptococcus pneumoniae remains a rare but important cause of neonatal sepsis and can mimic early onset Group B streptococcal sepsis. It is unclear whether current infant or adult pneumococcal immunisation programs might influence its incidence in the neonatal period. The potential for strains with reduced susceptibility to ß-lactam antibiotics to cause neonatal infection needs to be considered in relevant settings.
Asunto(s)
Antibacterianos/uso terapéutico , Penicilinas/uso terapéutico , Infecciones Neumocócicas/diagnóstico , Streptococcus pneumoniae , Femenino , Humanos , Recién Nacido , Masculino , Infecciones Neumocócicas/tratamiento farmacológico , Sepsis/tratamiento farmacológico , Sepsis/microbiologíaRESUMEN
Curtobacterium species are recognized plant pathogens. We report the first well-documented case of Curtobacterium human infection, a child with septic arthritis following puncture with a Coxspur Hawthorn plant thorn. The organism isolated from synovial tissue and the plant thorn was identified as Curtobacterium flaccumfaciens by 16S rRNA gene sequence analysis.
Asunto(s)
Infecciones por Actinomycetales/diagnóstico , Infecciones por Actinomycetales/patología , Actinomycetales/aislamiento & purificación , Artritis Infecciosa/diagnóstico , Artritis Infecciosa/patología , Crataegus , Heridas Penetrantes/complicaciones , Niño , ADN Bacteriano/química , ADN Bacteriano/genética , ADN Ribosómico/química , ADN Ribosómico/genética , Humanos , Masculino , ARN Ribosómico 16S/genética , Análisis de Secuencia de ADN , Líquido Sinovial/microbiologíaRESUMEN
A 6-week old infant who had been conceived through in-vitro fertilisation (IVF) presented with a skin lesion and enlarged lymph nodes, and developed severe respiratory distress. Mycobacterium tuberculosis was identified; his mother was the only potential source identified. To our knowledge, this is the first case of congenital tuberculosis after IVF reported in Australia and the second worldwide. It highlights the importance of adequate screening during investigation of infertility and the difficulties in diagnosing congenital tuberculosis.
