Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros












Base de datos
Intervalo de año de publicación
1.
Invest Ophthalmol Vis Sci ; 65(6): 15, 2024 Jun 03.
Artículo en Inglés | MEDLINE | ID: mdl-38848076

RESUMEN

Purpose: The purpose of this study was to investigate the associations between visual function and severity grading, corneal scatter, or higher-order aberrations (HOAs) in patients with Fuchs endothelial corneal dystrophy (FECD). Methods: This observational case series study included 49 eyes of 27 patients with FECD and 10 eyes of 10 healthy individuals. We evaluated corrected distance visual acuity (CDVA) using Landolt-C and Early Treatment Diabetic Retinopathy Study charts and contrast sensitivity using the CSV-1000E chart and CSV-1000RN letter chart. We analyzed the associations between visual function and explanatory variables, including age, modified Krachmer grade, central corneal thickness (CCT), anterior segment optical coherence tomography (AS-OCT)-based grade, HOAs, intraocular straylight, and corneal densitometry. We additionally conducted receiver operating characteristic (ROC) analysis to identify the corneal densitometry thresholds for decreased visual function. Results: There were significant associations between visual function and the modified Krachmer grade, CCT, AS-OCT-based grade, HOAs, intraocular straylight, and corneal densitometry. A modified Krachmer grade ≥ 3 was identified as a threshold for decreased visual function. Multivariate analysis showed that corneal densitometry was significantly associated with all visual function parameters, and HOAs were significantly associated with CDVA but not with contrast sensitivity. ROC analysis revealed that corneal densitometry of the posterior layer at 0 to 2 mm ≥ 10 grayscale units (GSU), was identified as a threshold for decreased visual function. Conclusions: HOAs, forward and backward light scatter affected visual function, with backward light scatter being the most influential. In patients with FECD, modified Krachmer grade ≥ 3 and corneal densitometry ≥ 10 GSU were thresholds for visual disturbance.


Asunto(s)
Sensibilidad de Contraste , Aberración de Frente de Onda Corneal , Distrofia Endotelial de Fuchs , Dispersión de Radiación , Agudeza Visual , Humanos , Distrofia Endotelial de Fuchs/fisiopatología , Distrofia Endotelial de Fuchs/diagnóstico , Femenino , Masculino , Agudeza Visual/fisiología , Persona de Mediana Edad , Anciano , Sensibilidad de Contraste/fisiología , Aberración de Frente de Onda Corneal/fisiopatología , Aberración de Frente de Onda Corneal/diagnóstico , Tomografía de Coherencia Óptica/métodos , Córnea/fisiopatología , Córnea/diagnóstico por imagen , Índice de Severidad de la Enfermedad , Curva ROC , Anciano de 80 o más Años , Adulto
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...