RESUMEN
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive myeloid malignancy associated with a poor prognosis. Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) has emerged as a potential treatment strategy for BPDCN, standardized conditioning regimens remain lacking. In this manuscript, we present two cases of BPDCN that were treated with a thiotepa-busulfan-fludarabine (TBF)-based conditioning regimen prior to allo-HSCT. Both cases demonstrated complete remission post-transplantation, sustained donor chimerism, and remission maintenance, suggesting the potential efficacy of the TBF conditioning regimen for BPDCN transplantation. Given the small sample size in our study, we emphasize caution and advocate for larger studies to confirm the efficacy of TBF in the treatment of BPDCN.
Asunto(s)
Busulfano , Células Dendríticas , Trasplante de Células Madre Hematopoyéticas , Tiotepa , Acondicionamiento Pretrasplante , Vidarabina , Humanos , Vidarabina/análogos & derivados , Vidarabina/administración & dosificación , Vidarabina/uso terapéutico , Acondicionamiento Pretrasplante/métodos , Células Dendríticas/patología , Tiotepa/administración & dosificación , Tiotepa/uso terapéutico , Masculino , Busulfano/administración & dosificación , Busulfano/uso terapéutico , Persona de Mediana Edad , Neoplasias Hematológicas/terapia , Neoplasias Hematológicas/patología , Femenino , Trasplante Homólogo , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , AloinjertosAsunto(s)
Insuficiencia Cardíaca , Neoplasias Cardíacas , Linfoma de Células B Grandes Difuso , Neoplasias del Timo , Humanos , Insuficiencia Cardíaca/etiología , Neoplasias del Timo/complicaciones , Linfoma de Células B Grandes Difuso/complicaciones , Linfoma de Células B Grandes Difuso/diagnóstico por imagen , Linfoma de Células B Grandes Difuso/tratamiento farmacológico , Neoplasias Cardíacas/diagnóstico por imagen , Neoplasias Cardíacas/tratamiento farmacológicoRESUMEN
Zr-N-codoped TiO2 nano-photocatalyst was prepared through sol-gel method using ammonia water and zirconium nitrate as the source of N and Zr, respectively. The resulting materials were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and ultraviolet-visible diffuse reflectance spectroscopy (UV-vis DRS). XRD results showed that codoping with Zr and N elements could greatly inhibit the phase transformation of TiO2 from anatase to rutile. XPS analysis indicated that Zr4+ was incorporated into the lattice of TiO2 through substituting titanium atoms. Meanwhile, N was also incorporated into the lattice of TiO2 through substituting oxygen atoms and existed in the form of N-Ti-O. DRS revealed that the light absorption edge of Zr-N-TiO2 was significantly red-shifted to visible region, leading to a narrower band gap and higher visible photocatalytic activity. The enhanced visible activity was attributed to the well anatase crystallite, intense light absorbance in visible region and narrow band gap.