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1.
J Urol ; 187(6): 2113-8, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-22503015

RESUMEN

PURPOSE: We determined the efficacy and safety of pelvic floor myofascial physical therapy compared to global therapeutic massage in women with newly symptomatic interstitial cystitis/painful bladder syndrome. MATERIALS AND METHODS: A randomized controlled trial of 10 scheduled treatments of myofascial physical therapy vs global therapeutic massage was performed at 11 clinical centers in North America. We recruited women with interstitial cystitis/painful bladder syndrome with demonstrable pelvic floor tenderness on physical examination and a limitation of no more than 3 years' symptom duration. The primary outcome was the proportion of responders defined as moderately improved or markedly improved in overall symptoms compared to baseline on a 7-point global response assessment scale. Secondary outcomes included ratings for pain, urgency and frequency, the O'Leary-Sant IC Symptom and Problem Index, and reports of adverse events. We compared response rates between treatment arms using the exact conditional version of the Mantel-Haenszel test to control for clustering by clinical center. For secondary efficacy outcomes cross-sectional descriptive statistics and changes from baseline were calculated. RESULTS: A total of 81 women randomized to the 2 treatment groups had similar symptoms at baseline. The global response assessment response rate was 26% in the global therapeutic massage group and 59% in the myofascial physical therapy group (p=0.0012). Pain, urgency and frequency ratings, and O'Leary-Sant IC Symptom and Problem Index decreased in both groups during followup, and were not significantly different between the groups. Pain was the most common adverse event, occurring at similar rates in both groups. No serious adverse events were reported. CONCLUSIONS: A significantly higher proportion of women with interstitial cystitis/painful bladder syndrome responded to treatment with myofascial physical therapy than to global therapeutic massage. Myofascial physical therapy may be a beneficial therapy in women with this syndrome.


Asunto(s)
Cistitis Intersticial/terapia , Masaje/métodos , Dolor Pélvico/terapia , Adolescente , Adulto , Anciano , Femenino , Humanos , Persona de Mediana Edad , Diafragma Pélvico , Método Simple Ciego , Adulto Joven
2.
J Obstet Gynaecol ; 29(8): 722-8, 2009 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-19821666

RESUMEN

This was a retrospective review of all cases of peripartum obstetric hysterectomy performed at the Istanbul Bakirkoy Women and Children's Teaching Hospital in the period between January 2001 and September 2008. We included any women who required emergency hysterectomy to control major postpartum haemorrhage after delivery. During the study period, there were 91 cases of peripartum hysterectomy. Two controls per case were randomly selected from the remaining births by using the random table. The incidence of emergency peripartum hysterectomy was 0.67 in 1,000 deliveries. The main indication for emergency hysterectomy was uterine atony in 52 cases (57.1%). The most independent risk factors for emergency hysterectomy were multiparity (odds ratios (OR) 17.3, 95% confidence interval (95% CI) 8.7-34.6); caesarean delivery in index delivery (OR 6.7, 95% CI 3.8-11.9) and caesarean section for placental abruption (OR 3.8, 95% CI 0.4-33.4). Our study suggests that multiparity, primary or repeat caesarean deliveries for placental abruption are independently associated risks for peripartum hysterectomy and uterine atony is the still most common indication for peripartum hysterectomy in Turkey.


Asunto(s)
Histerectomía/estadística & datos numéricos , Complicaciones del Trabajo de Parto/cirugía , Hemorragia Posparto/cirugía , Periodo Posparto , Desprendimiento Prematuro de la Placenta/cirugía , Adulto , Estudios de Casos y Controles , Cesárea/efectos adversos , Urgencias Médicas , Femenino , Humanos , Incidencia , Paridad , Hemorragia Posparto/epidemiología , Hemorragia Posparto/etiología , Embarazo , Estudios Retrospectivos , Factores de Riesgo , Turquía/epidemiología , Inercia Uterina/cirugía
3.
Intern Med J ; 38(6): 438-41, 2008 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-18613898

RESUMEN

Drug-induced haemolytic anaemia can be life threatening. We report a case of ceftriaxone-induced severe haemolytic anaemia in a previously healthy 68-year-old woman. The patient had a positive direct antiglobulin test (anti-C3d positive, anti-immunoglobulin G negative). Serological tests showed ceftriaxone-specific antibodies. The patient recovered after cessation of the drug. This complication may cause milder anaemia and thus be poorly recognized.


Asunto(s)
Anemia Hemolítica/inducido químicamente , Antibacterianos/efectos adversos , Anticuerpos/inmunología , Ceftriaxona/efectos adversos , Hemólisis/inmunología , Anciano , Anemia Hemolítica/sangre , Anemia Hemolítica/inmunología , Antibacterianos/administración & dosificación , Antibacterianos/inmunología , Anticuerpos/sangre , Ceftriaxona/administración & dosificación , Ceftriaxona/inmunología , Endocarditis Bacteriana/tratamiento farmacológico , Femenino , Estudios de Seguimiento , Humanos , Inyecciones Intravenosas
5.
Blood ; 83(4): 1136-42, 1994 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-8111053

RESUMEN

Chelation therapy with deferoxamine is effective in preventing the risk of transfusional iron overload, but treatment failure is common because of noncompliance. To reduce the transfusional iron load, we have evaluated longterm erythrocytapheresis in 14 subjects with sickle cell disease and stroke (11) or other complications (3) as an alternative to simple transfusion. Subjects were treated with erythrocytapheresis using the Haemonetics V50 (Haemonetics Corp, Braintree, MA) to maintain the target pretransfusion hemoglobin S (Hb S) level less than 50% for 6 to 71 months. The transfusional iron load and the donor blood usage were analyzed for a 6- to 36-month study period and were compared with similar data from a subset of 7 subjects previously treated with conventional (target Hb S < 30%) and modified (target Hb S < 50%) simple transfusion protocols. The effect of erythrocytapheresis on iron accumulation was determined by assessment of serum ferritin levels in the absence of iron chelation. The mean transfusional iron load and donor blood usage with erythrocytapheresis were 19 +/- 14 mg iron/kg/yr (range, 6 to 50) and 188.4 +/- 55.2 mL packed-red blood cells (RBC)/kg/yr (range, 107 to 281), respectively. Of 6 subjects receiving no iron chelation therapy, 5 maintained normal or nearly normal serum ferritin levels during 11 to 36 months of erythrocytapheresis. In comparison with conventional simple transfusion and modified simple transfusion, erythrocytapheresis reduced iron loading by 87% (P < .01) and 82% (P < .01), respectively, but increased donor blood usage by 23% and 73%, respectively. Subjects with pre-erythrocytapheresis Hb levels > or = 8.0 g/dL had lower iron accumulation (P < .001) and less donor blood usage (P < .005) than subjects with Hb levels < or = 8.0 g/dL. Although donor blood usage is increased in comparison with simple transfusion, long-term erythrocytapheresis markedly reduces or prevents iron accumulation. This form of transfusion therapy allows the cessation of iron chelation in well-chelated subjects and, if used as the initial form of transfusion therapy, may prevent long-term complications of sickle cell disease without risk of iron overload and the need for chelation therapy.


Asunto(s)
Anemia de Células Falciformes/terapia , Eliminación de Componentes Sanguíneos , Transfusión de Eritrocitos , Eritrocitos , Hierro/sangre , Reacción a la Transfusión , Adolescente , Adulto , Anemia de Células Falciformes/sangre , Recuento de Células Sanguíneas , Niño , Recuento de Eritrocitos , Humanos
7.
Phys Ther ; 67(6): 921-5, 1987 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-3588678

RESUMEN

The purpose of this study was to estimate the reliability of body density measurements from the hydrostatic weights of subjects with spinal injuries in standard sit-in and Hubbard tanks. Nineteen outpatients with spinal injuries participated in the study. Residual lung volume and hydrostatic weights were measured in two laboratories. Body density and percentage of body fat were determined from hydrostatic weights. Statistical tools were the t test for correlated samples and the Pearson product-moment correlation coefficient. The alpha level was set at .05. Reliability coefficients for body density and percentage of body fat were .98 and .99, respectively (p less than .05). Trial means were not significantly different. We conclude that a standard sit-in tank or a Hubbard tank can be used to determine body density and percentage of body fat of patients with spinal injuries. Modifications should be made for sitting posture, and standard densitometric procedures should be followed.


Asunto(s)
Composición Corporal , Peso Corporal , Densitometría , Inmersión , Traumatismos de la Médula Espinal , Adulto , Femenino , Humanos , Mediciones del Volumen Pulmonar , Masculino , Persona de Mediana Edad , Modelos Biológicos , Paraplejía , Postura , Cuadriplejía
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