RESUMEN
Dibromosterculic acid [8-(1,2-dibromo-2-octylcyclopropyl)-octanoic acid], a new synthetic derivative was prepared by bromination of sterculic acid. This synthetic derivative showed strong fungicidal activity against two pathogenic fungal species namely Penicillium chrysogenum and Aspergillus niger with minimum inhibitory concentration (MIC) value of 0.007 mg/ml and good bactericidal activity against Bacillus subtilis and Xanthomonas sp. with MIC value of 0.015 mg/ml. Cytotoxic activity on both normal (MCF-10A) and cancerous (MDA-MB-468) cell lines revealed that the survivability percentage of normal cells was unaffected, whereas cancerous cells were decreased greatly by dibromosterculic acid with 50% survivability at 9 µg/ml concentration. Molecular-docking using AutoDock 4.2 with Bax exhibited strong pi-sigma interaction with PHE-93, pi-alkyl and alkyl interaction with TRP-139, ARG-89 and PHE-92 whereas MDM2 revealed strong hydrogen bond interaction with GLN-59 and pi-alkyl interaction with PHE-55. All experimental parameters suggested that this synthetic derivative would be valuable for target-specific drug development with nominal side effects.
RESUMEN
Aim of the study: The objective of the current study is to assess and establish a relationship between the mode of delivery and postnatal factors in the early colonization of Streptococcus mutans (S. mutans) in infants' oral cavities. Materials and methods: The primary goal of the investigation is to assess and compare the oral microflora of newborns immediately after birth and at 3, 6, 9, and 12 months of age in babies born by normal vaginal delivery and lower segment cesarean section and divided into (group III) and (group V), respectively. Around 50 mother-baby pairs in total had their swab samples collected for the identification of S. mutans and were monitored for a year. The role of other postnatal factors in the acquisition of S. mutans in infants was also evaluated. Results: Data analysis showed that different postnatal factors like feeding patterns, oral hygiene practices, and socioeconomic factors affected the infant's oral cavity's initial colonization by S. mutans. Conclusion: Infants' first exposure to oral S. mutans depends on the delivery method and various postnatal factors. How to cite this article: Sharma N, Bhargava N, Boruah B, et al. Evaluation of Mode of Delivery and Various Postnatal Factors on Acquisition of Oral Streptococcus mutans in Infants: A Prospective Study. Int J Clin Pediatr Dent 2023;16(5):663-666.
RESUMEN
Hot taste spices have enormous health benefits starting from kitchen to pharmaceutical laboratories. Our present study is focused on phytochemical and pharmacological screening of six hot taste spices namely Zingiber officinale (ginger), Capsicum annuum (chilli), Piper chaba (java long pepper), Piper nigrum (black pepper), Syzygium aromaticum (clove), Trachyspermum ammi (carom). Among all six spices, clove and ginger exhibited strong antioxidant activity owing to higher phytochemical contents. Significant antifungal activity (IZD ≥ 11 mm) was revealed by all six spices except hexane fraction of carom whereas strong antibacterial activity with lowest MIC was displayed by clove, ginger and chilli. DNA was successfully protected from oxidative damage by clove, ginger followed by chilli, java long pepper and carom but black pepper could only partially protect DNA damage even at 4 mg/ml concentration. Based on the DNA damage protecting potentials and antioxidant activities clove, ginger, java long pepper and carom may be utilized for neutraceuticals development. Antimicrobial activities suggested that clove, ginger, java long pepper and chilli may be useful as food preservatives. Fractionated bioactivity of the all the six HTS would help for targeted extraction and development of nutraceuticals from these commonly used medicinal spices.
