RESUMEN
The agreement of experts of the Eurasian Association of Therapists (EAT) discusses pathogenesis and treatment of COVID-19. Modern data on the characteristics of cardiovascular, kidney, respiratory damage in SARS-infected CoV-2 are presented. The tactics of managing patients initially having cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, bronchial asthma, chronic kidney disease are discussed in detail. The article presents data on drug interaction of drugs.
Asunto(s)
Asma , COVID-19 , Diabetes Mellitus , Enfermedad Pulmonar Obstructiva Crónica , Humanos , SARS-CoV-2RESUMEN
This article discusses relevant aspects in the treatment of patients with COVID-19. Up-to-date information about principles for administration of statins, antithrombotics, and antiarrhythmics is presented. The authors addressed in detail specific features of reversing heart rhythm disorders in patients with coronavirus infection and the interaction of antiarrhythmic and antiviral drugs. Recommendations are provided for outpatient and inpatient antithrombotic therapy for patients with COVID-19. Issues of antithrombotic and antiviral drug interaction are discussed.
Asunto(s)
Anticoagulantes , Cardiología , Infecciones por Coronavirus , Inhibidores de Hidroximetilglutaril-CoA Reductasas , Pandemias , Neumonía Viral , Antiarrítmicos/uso terapéutico , Anticoagulantes/uso terapéutico , Betacoronavirus , COVID-19 , Infecciones por Coronavirus/tratamiento farmacológico , Infecciones por Coronavirus/epidemiología , Humanos , Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico , Neumonía Viral/tratamiento farmacológico , Neumonía Viral/epidemiología , Federación de Rusia , SARS-CoV-2 , Sociedades Médicas , Tratamiento Farmacológico de COVID-19RESUMEN
The article discusses pathogenesis and treatment of COVID-19. The authors presented state-of-the-art insight into hemostatic disorders in patients with COVID-19 and clinical recommendations on prevention of thrombosis and thromboembolism in patients infected with SARS-CoV-2. The article discussed in detail a new hypothesis proposed by Chinese physicians about a new component in the pathogenesis of COVID-19, namely, about the effect of SARS-CoV-2 virus on the hemoglobin beta-chain and the formation of a complex with porphyrin, which results in displacement of the iron ion. Thus, hemoglobin loses the capability for transporting oxygen, which aggravates hypoxia and worsens the prognosis. The article stated rules of hemotransfusion safety in the conditions of COVID-19 pandemic.
Asunto(s)
Análisis de los Gases de la Sangre , Transfusión Sanguínea , Infecciones por Coronavirus/fisiopatología , Hemostasis , Neumonía Viral/fisiopatología , Betacoronavirus , COVID-19 , Hemoglobinas , Humanos , Hipoxia , Hierro , Pandemias , Porfirinas , SARS-CoV-2RESUMEN
Endothelium function was assessed from endothelium-dependent vasodilation and plasma endothelin-1 (ET-1) levels in 16 patients with arterial hypertyension (AH) and insulin resistance (IR) and compared with that in 22 patients with AH without IR. IR was diagnosed indirectly from the fasting glucose-to-insulin ratio in venous blood below 6. Additional studies included round-the-clock monitoring arterial pressure, reactive hyperemia test, and immunoreactive ET-1 assay. Major changes revealed in the patients with AH and IR were a smaller-than-normal diameter of the humeral artery, its decreased incremental growth, and elevated plasma ET-1 compared with the AH patients without IR. It is concluded that patients with AH and IR exhibit more pronounced dysfunction of endothelium than patients with AH without metabolic disorders.
