RESUMEN
A novel series of 1-aryl-N-[4-phenyl-5-(arylazo)thiazol-2-yl)methanimines has been synthesized via the condensation of 2-amino-4-phenyl-5-arylazothiazole with various aromatic aldehydes. The synthesized imines were characterized by spectroscopic techniques, namely 1H and 13C-NMR, FTIR, MS, and Elemental Analysis. A molecular comparative docking study for 3a-f was calculated, with reference to two approved drugs, Molnupiravir and Remdesivir, using 7BQY (Mpro; PDB code 7BQY; resolution: 1.7 A°) under identical conditions. The binding scores against 7BQY were in the range of -7.7 to -8.7 kcal/mol for 3a-f. The high scores of the compounds indicated an enhanced binding affinity of the molecules to the receptor. This is due to the hydrophobic interactions and multi-hydrogen bonds between 3a-f ligands and the receptor's active amino acid residues. The main aim of using in silco molecular docking was to rank 3a-f with respect to the approved drugs, Molnupiravir and Remdesivir, using free energy methods as greener pastures. A further interesting comparison presented the laydown of the ligands before and after molecular docking. These results and other supporting statistical analyses suggested that ligands 3a-f deserve further investigation in the context of potential therapeutic agents for COVID-19. Free-cost, PASS, SwissADME, and Way2drug were used in this research paper to determine the possible biological activities and cytotoxicity of 3a-f.
Asunto(s)
Antivirales/química , Tratamiento Farmacológico de COVID-19 , Iminas/química , Tiazoles/química , Adenosina Monofosfato/análogos & derivados , Adenosina Monofosfato/química , Alanina/análogos & derivados , Alanina/química , Antivirales/síntesis química , Antivirales/farmacocinética , Antivirales/toxicidad , Sitios de Unión , Simulación por Computador , Proteasas 3C de Coronavirus/química , Citidina/análogos & derivados , Citidina/química , Hidroxilaminas/química , Iminas/síntesis química , Iminas/farmacocinética , Iminas/toxicidad , Simulación del Acoplamiento Molecular , SARS-CoV-2/efectos de los fármacos , Tiazoles/síntesis química , Tiazoles/farmacocinética , Tiazoles/toxicidadRESUMEN
A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl-[1,2,4]triazepino[2,3-H]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderate activity towards bacteria.
